Results 91 to 100 of about 855,599 (268)
Frontiers in Microbiology, 2017 Essential gene functions remain largely underexplored in bacteria. Clostridium cellulolyticum is a promising candidate for consolidated bioprocessing; however, its genetic manipulation to reduce the formation of less-valuable acetate is technically ...
Tao Xu +6 more
doaj +1 more source
Csm4-dependent telomere movement on nuclear envelope promotes meiotic recombination. [PDF]
PLoS Genetics, 2008 During meiotic prophase, chromosomes display rapid movement, and their telomeres attach to the nuclear envelope and cluster to form a "chromosomal bouquet." Little is known about the roles of the chromosome movement and telomere clustering in this phase.
Hiromichi Kosaka +2 more
doaj +1 more source
Genes & Development, 2009 Eukaryotes possess mechanisms to limit crossing over during homologous recombination, thus avoiding possible chromosomal rearrangements. We show here that budding yeast Mph1, an ortholog of human FancM helicase, utilizes its helicase activity to suppress
Rohit Prakash +10 more
semanticscholar +1 more source
Distributed AutoML framework for multi‐objective optimization of concrete crack segmentation models
Structural Concrete, EarlyView.Abstract Monitoring cracks in concrete surfaces is essential for structural safety. While machine vision techniques have received significant interest in this domain, selecting optimal models and tuning hyperparameters remain challenging. This paper proposes a Distributed Automated Machine Learning (AutoML) framework for efficiently designing and ...
Armin Dadras Eslamlou +3 more
wiley +1 more source
eLife, 2013 During gamete formation, crossover recombination must occur on replicated DNA to ensure proper chromosome segregation in the first meiotic division. We identified a Mec1/ATR- and Dbf4-dependent replication checkpoint in budding yeast that prevents the ...
Hannah G Blitzblau, Andreas Hochwagen
doaj +1 more source
Massive Crossover Suppression by CRISPR-Cas-mediated Plant Chromosome Engineering [PDF]
, 2022 Michelle Rönspies +5 more
openalex +1 more source
XSim: Simulation of Descendants from Ancestors with Sequence Data. [PDF]
, 2015 Real or imputed high-density SNP genotypes are routinely used for genomic prediction and genome-wide association studies. Many researchers are moving toward the use of actual or imputed next-generation sequence data in whole-genome analyses.
Cheng, Hao +2 more
core +2 more sources
Genes & Development, 1998 To directly determine whether recombinational repair of double-strand breaks (DSBs) can occur between heterologous chromosomes and lead to chromosomal rearrangements in mammalian cells, we employed an ES cell system to analyze recombination between ...
C. Richardson, M. Moynahan, M. Jasin
semanticscholar +1 more source
Shear wall plan layout optimization considering seismic loads
Structural Concrete, EarlyView.Abstract Seismic force resistant structural design requires experience and time. Shear wall elements are generally used in concrete structures due to their high stiffness against horizontal forces. The aim of this study is to obtain optimum structural wall disposition by using building information modeling (BIM) technologies.
Ahmet Çağatay Tahaoğlu, Yasin Fahjan
wiley +1 more source
Evidence that masking of synapsis imperfections counterbalances quality control to promote efficient meiosis. [PDF]
PLoS Genetics, 2013 Reduction in ploidy to generate haploid gametes during sexual reproduction is accomplished by the specialized cell division program of meiosis. Pairing between homologous chromosomes and assembly of the synaptonemal complex at their interface (synapsis ...
Susanna Mlynarczyk-Evans +2 more
doaj +1 more source