Results 121 to 130 of about 855,599 (268)

High-resolution mapping of heteroduplex DNA formed during UV-induced and spontaneous mitotic recombination events in yeast. [PDF]

, 2017
In yeast, DNA breaks are usually repaired by homologous recombination (HR). An early step for HR pathways is formation of a heteroduplex, in which a single-strand from the broken DNA molecule pairs with a strand derived from an intact DNA molecule.
Dominska, Margaret, Petes, Thomas D, Yim, Eunice, Yin, Yi   +3 more
core   +3 more sources

A genetic algorithm simheuristic for solving the stochastic project portfolio selection problem with portfolio reliability constraints

International Transactions in Operational Research, EarlyView.
Abstract In response to the increasing complexity of modern products, dynamic markets, and intensified competition, project‐based organizations are actively seeking methodologies to efficiently manage their expanding project portfolios. This paper analyzes the project portfolio selection problem in uncertain environments. Despite recent advances in the
Miguel Saiz, David Lopez‐Lopez, Laura Calvet, Angel A. Juan   +3 more
wiley   +1 more source

An iterated greedy‐based metaheuristic with local search for the rank pricing problem

International Transactions in Operational Research, EarlyView.
Abstract The rank pricing problem involves determining optimal prices for a set of products while accounting for customers' budgets and preferences. This study develops an iterated greedy‐based metaheuristic to efficiently solve this problem. The core idea is to generate a sequence of solutions by iteratively applying destruction and reconstruction ...
Herminia I. Calvete, Carmen Galé, Aitor Hernández, José A. Iranzo   +3 more
wiley   +1 more source

Statistics on continuous IBD data: Exact distribution evaluation for a pair of full(half)-sibs and a pair of a (great-) grandchild with a (great-) grandparent

BMC Genetics, 2002
Background Pairs of related individuals are widely used in linkage analysis. Most of the tests for linkage analysis are based on statistics associated with identity by descent (IBD) data.
Stefanov Valeri T
doaj   +1 more source

An Increase in Male Recombination Rate With Age in Dairy Cattle Is Heritable and Polygenic

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Meiotic recombination is an essential process for shuffling genetic diversity in sexually reproducing organisms, can vary within and between individuals in response to intrinsic and extrinsic factors, and can be heritable. Interestingly, recombination rate has been found to vary with age in some species, but to date, there have been no ...
Evelyn Jade, Mathew D. Littlejohn, Katie Eketone, Richard J. Spelman, Jessica Stapley, Anna W. Santure   +5 more
wiley   +1 more source

Sequencing of Single Pollen Nuclei Reveals Meiotic Recombination Events at Megabase Resolution and Circumvents Segregation Distortion Caused by Postmeiotic Processes

Frontiers in Plant Science, 2017
Meiotic recombination is a fundamental mechanism to generate novel allelic combinations which can be harnessed by breeders to achieve crop improvement. The recombination landscape of many crop species, including the major crop barley, is characterized by
Steven Dreissig, Jörg Fuchs, Axel Himmelbach, Martin Mascher, Martin Mascher, Andreas Houben   +5 more
doaj   +1 more source

Evolution of Hybrid Inviability Associated With Chromosome Fusions

Molecular Ecology, EarlyView.
ABSTRACT Chromosomal rearrangements, such as inversions, have received considerable attention in the speciation literature due to their hampering effects on recombination. Less is known about how other rearrangements, such as chromosome fissions and fusions, can affect the evolution of reproductive isolation. Here, we use crosses between populations of
Jesper Boman, Karin Näsvall, Roger Vila, Christer Wiklund, Niclas Backström   +4 more
wiley   +1 more source

Mixed Outcomes in Recombination Rates After Domestication: Revisiting Theory and Data

Molecular Ecology, EarlyView.
ABSTRACT The process of domestication has altered many phenotypes. Selection on these phenotypes has long been hypothesised to indirectly select for increases in the genome‐wide recombination rate. This hypothesis is potentially consistent with theory on the evolution of the recombination rate, but empirical support has been unclear. We review relevant
Madeline Bursell, Manav Rohilla, Lucia Ramirez, Yuhuan Cheng, Enrique J. Schwarzkopf, Rafael F. Guerrero, Caiti Smukowski Heil   +6 more
wiley   +1 more source

CRISPR/Cas9-induced DNA breaks trigger crossover, chromosomal loss, and chromothripsis-like rearrangements [PDF]

, 2023
Aviva Samach, Fabrizio Mafessoni, Or Gross, Cathy Melamed‐Bessudo, Shdema Filler‐Hayut, Tal Dahan‐Meir, Ziva Amsellem, Wojciech P. Pawlowski, Avraham A. Levy   +8 more
openalex   +1 more source

Rate of Adaptation in Large Sexual Populations

, 2010
Adaptation often involves the acquisition of a large number of genomic changes which arise as mutations in single individuals. In asexual populations, combinations of mutations can fix only when they arise in the same lineage, but for populations in ...
Fisher, Daniel S., Neher, Richard A., Shraiman, Boris I.   +2 more
core   +2 more sources