Results 151 to 160 of about 33,239 (264)

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Ex Vivo Spatiotemporal Characterization of Spermatogenesis in Mouse Testicular Organoids

Advanced Science, Volume 13, Issue 4, 19 January 2026.
To date, in vitro spermatogenesis remains a challenge in reproductive medicine. In this study, Sun et al. developed a promising in vitro strategy to generate testicular organoids that enable germ cells from newborn mice to enter meiosis, complete chromosome recombination and synapsis, and develop into haploid spermatids.
Jiachen Sun, Lifa Zhu, Yutong Li, Jinyan Tang, Tao Zhang, Hengjia Zhang, Wanchu Wang, Lufan Li, Shuhui Bian, Xin Wu   +9 more
wiley   +1 more source

Zn‐Assisted Mg Ion Transport in Spinel Oxide Cathodes: Insights From Neural Network Simulations

Chemistry – An Asian Journal, Volume 21, Issue 2, 28 January 2026.
ABSTRACT We investigated Mg insertion and ion transport in defect spinel MgxZnMnO3 (0 ≤ x ≤ 1) using a neural network potential combined with molecular dynamics and genetic algorithm–based structure exploration. The diffusion coefficients showed a strong composition dependence: both stoichiometric spinel (x = 0.25) and rock‐salt (x = 1.0) exhibited ...
Riku Nakahara, Naoto Tanibata, Hayami Takeda, Masanobu Nakayama, Kohei Shimokawa, Tetsu Ichitsubo   +5 more
wiley   +1 more source

Meiotic double-strand break repair DNA synthesis tracts in Arabidopsis thaliana.

PLoS Genetics
We report here the successful labelling of meiotic prophase I DNA synthesis in the flowering plant, Arabidopsis thaliana. Incorporation of the thymidine analogue, EdU, enables visualisation of the footprints of recombinational repair of programmed ...
Miguel Hernández Sánchez-Rebato, Veit Schubert, Charles I White   +2 more
doaj   +1 more source

Rate of Adaptation in Large Sexual Populations

, 2010
Adaptation often involves the acquisition of a large number of genomic changes which arise as mutations in single individuals. In asexual populations, combinations of mutations can fix only when they arise in the same lineage, but for populations in ...
Fisher, Daniel S., Neher, Richard A., Shraiman, Boris I.   +2 more
core   +2 more sources

The Origin of 2 Sexes Through Optimization of Recombination Entropy Against Time and Energy [PDF]

, 2006
Sexual reproduction in Nature requires two sexes, which raises the question why the reproductive scheme did not evolve to have three or more sexes. Here we construct a constrained optimization model based on the communication theory to analyze trade-offs
Deng, Bo
core   +3 more sources

Mathematical Modeling of Amoxicillin Synthesis in Batch and Semi‐Batch Reactor: Application of Bayesian Statistics and Genetic Algorithm

Biotechnology and Bioengineering, Volume 123, Issue 1, Page 104-115, January 2026.
Synthesis of amoxicillin: The reaction catalyzed by penicillin G acylase is investigated in an enzymatic reactor, considering both Michaelis–Menten and mechanism‐based models with reaction and equilibrium constants. Parameters are estimated via MCMC and Genetic Algorithm, with MCMC showing superior performance in validating the mathematical model in a ...
Lucas Figueiredo Formigosa, Ingrid Cabral dos Santos, Letícia Eduarda Alves e Álvares, Emanuel Negrão Macêdo, Luciana Rocha Barros Gonçalves, Bruno Marques Viegas   +5 more
wiley   +1 more source

Single-crossover integration in the Lactobacillus sake chromosome and insertional inactivation of the ptsI and lacL genes [PDF]

, 1997
Ludovic Leloup, S. Dusko Ehrlich, Monique Zagorec, Françoise Morel-Deville   +3 more
openalex   +1 more source

Mechanical Coupling With the Nuclear Envelope Shapes the Schizosaccharomyces pombe Mitotic Spindle

Cytoskeleton, Volume 83, Issue 1, Page 40-52, January 2026.
ABSTRACT The fission yeast Schizosaccharomyces pombe divides via closed mitosis, meaning that spindle elongation and chromosome segregation transpire entirely within the closed nuclear envelope. Both the spindle and nuclear envelope must undergo shape changes and exert varying forces on each other during this process.
Marcus A. Begley, Taylor Mahoney, Christian Pagán Medina, Parsa Zareiesfandabadi, Matthew B. Rapp, Mastawal Tirfe, Sharonda J. LeBlanc, Meredith D. Betterton, Mary Williard Elting   +8 more
wiley   +1 more source

The Chromosome Axis Mediates Feedback Control of CHK-2 to Ensure Crossover Formation in C. elegans [PDF]

, 2015
Yumi Kim, Nora Kostow, Abby F. Dernburg
openalex   +1 more source