Deciphering complex genome rearrangements in C. elegans using short-read whole genome sequencing
Scientific Reports, 2021 Genomic rearrangements cause congenital disorders, cancer, and complex diseases in human. Yet, they are still understudied in rare diseases because their detection is challenging, despite the advent of whole genome sequencing (WGS) technologies.
Tatiana Maroilley +5 more
doaj +1 more source
Regulation of Crossover Frequency and Distribution during Meiotic Recombination.
Cold Spring Harbor Symposia on Quantitative Biology, 2017 Crossover recombination is essential for generating genetic diversity and promoting accurate chromosome segregation during meiosis. The process of crossover recombination is tightly regulated and is initiated by the formation of programmed meiotic DNA ...
Takamune T. Saito, M. Colaiácovo
semanticscholar +1 more source
Human imprinted chromosomal regions are historical hot-spots of recombination. [PDF]
PLoS Genetics, 2006 Human recombination rates vary along the chromosomes as well as between the two sexes. There is growing evidence that epigenetic factors may have an important influence on recombination rates, as well as on crossover position.
Ionel Sandovici +5 more
doaj +1 more source
Generation of targeted homozygosity in the genome of human induced pluripotent stem cells.
PLoS ONE, 2019 When loss of heterozygosity (LOH) is correlated with loss or gain of a disease phenotype, it is often necessary to identify which gene or genes are involved.
Yasuhide Yoshimura +4 more
doaj +1 more source
Full-length synaptonemal complex grows continuously during meiotic prophase in budding yeast. [PDF]
PLoS Genetics, 2012 the synaptonemal complex (SC) links two meiotic prophase chromosomal events: homolog pairing and crossover recombination. SC formation involves the multimeric assembly of coiled-coil proteins (Zip1 in budding yeast) at the interface of aligned homologous
Karen Voelkel-Meiman +4 more
doaj +1 more source
Genome-wide high-resolution mapping of UV-induced mitotic recombination events in Saccharomyces cerevisiae. [PDF]
, 2013 In the yeast Saccharomyces cerevisiae and most other eukaryotes, mitotic recombination is important for the repair of double-stranded DNA breaks (DSBs). Mitotic recombination between homologous chromosomes can result in loss of heterozygosity (LOH).
Petes, Thomas D, Yin, Yi
core +1 more source
Apoptosis in mouse fetal and neonatal oocytes during meiotic prophase one [PDF]
, 2007 Background The vast majority of oocytes formed in the fetal ovary do not survive beyond birth. Possible reasons for their loss include the elimination of non-viable genetic constitutions arising through meiosis, however, the ...
Ghafari , Fataneh +2 more
core +4 more sources
Positive regulation of meiotic DNA double-strand break formation by activation of the DNA damage checkpoint kinase Mec1(ATR) [PDF]
, 2013 During meiosis, formation and repair of programmed DNA double-strand breaks (DSBs) create genetic exchange between homologous chromosomes-a process that is critical for reductional meiotic chromosome segregation and the production of genetically diverse ...
Allison, Rachal M +4 more
core +1 more source
PLoS Genetics, 2019 Accurate chromosome segregation during meiosis relies on the prior establishment of at least one crossover recombination event between homologous chromosomes. Most meiotic recombination intermediates that give rise to interhomolog crossovers are embedded
Karen Voelkel-Meiman +8 more
doaj +1 more source
Srs2 promotes synthesis-dependent strand annealing by disrupting DNA polymerase δ-extending D-loops
eLife, 2017 Synthesis-dependent strand annealing (SDSA) is the preferred mode of homologous recombination in somatic cells leading to an obligatory non-crossover outcome, thus avoiding the potential for chromosomal rearrangements and loss of heterozygosity.
Jie Liu +8 more
doaj +1 more source