Full-length synaptonemal complex grows continuously during meiotic prophase in budding yeast. [PDF]
PLoS Genetics, 2012 the synaptonemal complex (SC) links two meiotic prophase chromosomal events: homolog pairing and crossover recombination. SC formation involves the multimeric assembly of coiled-coil proteins (Zip1 in budding yeast) at the interface of aligned homologous
Karen Voelkel-Meiman +4 more
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The kinetochore prevents centromere-proximal crossover recombination during meiosis
eLife, 2015 During meiosis, crossover recombination is essential to link homologous chromosomes and drive faithful chromosome segregation. Crossover recombination is non-random across the genome, and centromere-proximal crossovers are associated with an increased ...
Nadine Vincenten +9 more
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Genome-wide high-resolution mapping of UV-induced mitotic recombination events in Saccharomyces cerevisiae. [PDF]
, 2013 In the yeast Saccharomyces cerevisiae and most other eukaryotes, mitotic recombination is important for the repair of double-stranded DNA breaks (DSBs). Mitotic recombination between homologous chromosomes can result in loss of heterozygosity (LOH).
Petes, Thomas D, Yin, Yi
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Fine-Scale Crossover Rate Variation on the Caenorhabditis elegans X Chromosome
G3 Genes|Genomes|Genetics, 2016 Abstract Meiotic recombination creates genotypic diversity within species. Recombination rates vary substantially across taxa, and the distribution of crossovers can differ significantly among populations and between sexes. Crossover locations within species have been found to vary by chromosome and by position within chromosomes ...
Max R. Bernstein, Matthew V. Rockman
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A Computational Approach to Estimating Nondisjunction Frequency in Saccharomyces cerevisiae. [PDF]
, 2016 Errors segregating homologous chromosomes during meiosis result in aneuploid gametes and are the largest contributing factor to birth defects and spontaneous abortions in humans.
Burgess, Sean M, Chu, Daniel B
core +3 more sources
PLoS Genetics, 2019 Accurate chromosome segregation during meiosis relies on the prior establishment of at least one crossover recombination event between homologous chromosomes. Most meiotic recombination intermediates that give rise to interhomolog crossovers are embedded
Karen Voelkel-Meiman +8 more
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Population-wide single-pollen nuclei genotyping in rye sheds light on the genetic basis and environmental plasticity of meiotic recombination. [PDF]
New PhytolSummary The core molecular machinery of meiosis is conserved deep across eukaryotic lineages. Nevertheless, recombination landscapes vary at multiple scales, from chromosomes to populations, caused by an interaction between genetic and environmental factors.
Waesch C +7 more
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Unisexual reproduction drives meiotic recombination and phenotypic and karyotypic plasticity in Cryptococcus neoformans. [PDF]
PLoS Genetics, 2014 In fungi, unisexual reproduction, where sexual development is initiated without the presence of two compatible mating type alleles, has been observed in several species that can also undergo traditional bisexual reproduction, including the important ...
Sheng Sun +3 more
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Meiotic DSB patterning: A multifaceted process [PDF]
, 2016 Meiosis is a specialized two-step cell division responsible for genome haploidization and the generation of genetic diversity during gametogenesis. An integral and distinctive feature of the meiotic program is the evolutionarily conserved initiation of ...
Barlow C +7 more
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Where to Cross Over? Defining Crossover Sites in Plants
Frontiers in Genetics, 2018 It is believed that recombination in meiosis serves to reshuffle genetic material from both parents to increase genetic variation in the progeny. At the same time, the number of crossovers is usually kept at a very low level.
Julia Dluzewska +2 more
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