Results 71 to 80 of about 855,599 (268)
Biotechnology for Biofuels, 2018 Background Clostridium saccharobutylicum NCP 262 is a solventogenic bacterium that has been used for the industrial production of acetone, butanol, and ethanol. The lack of a genetic manipulation system for C.
Ching-Ning Huang +2 more
doaj +1 more source
Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae. [PDF]
, 2017 Genome rearrangements result in mutations that underlie many human diseases, and ongoing genome instability likely contributes to the development of many cancers.
Kolodner, Richard D +1 more
core +1 more source
Mechanical Coupling With the Nuclear Envelope Shapes the Schizosaccharomyces pombe Mitotic Spindle
Cytoskeleton, EarlyView.ABSTRACT The fission yeast Schizosaccharomyces pombe divides via closed mitosis, meaning that spindle elongation and chromosome segregation transpire entirely within the closed nuclear envelope. Both the spindle and nuclear envelope must undergo shape changes and exert varying forces on each other during this process.
Marcus A. Begley +8 more
wiley +1 more source
Cytoskeleton, EarlyView.ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves +3 more
wiley +1 more source
Staphylococcus aureus DivIB is a peptidoglycan-binding protein that is required for a morphological checkpoint in cell division [PDF]
, 2014 Bacterial cell division is a fundamental process that requires the coordinated actions of a number of proteins which form a complex macromolecular machine known as the divisome.
Bottomley, Amy L. +5 more
core +1 more source
Protocol for Constructing a Gene Knockout in Pseudomonas Using pT18mobsacB
Food Safety and Health, EarlyView.A streamlined protocol for scarless gene knockout in Pseudomonas using the tetracycline‐resistant suicide plasmid pT18mobsacB is presented. The method enables efficient two‐step allelic exchange and is broadly applicable to Gram‐negative bacteria. ABSTRACT Gene knockout via homologous recombination is a powerful approach for investigating gene function
Han Yang +4 more
wiley +1 more source
PLoS Genetics, 2009 Meiotic crossovers are produced when programmed double-strand breaks (DSBs) are repaired by recombination from homologous chromosomes (homologues). In a wide variety of organisms, meiotic HORMA-domain proteins are required to direct DSB repair towards ...
Lukasz Wojtasz +11 more
semanticscholar +1 more source
Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, EarlyView.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source
sequenceLDhot: Detecting Recombination Hotspots. [PDF]
, 2006 Motivation: There is much local variation in recombination rates across the human genome—with the majority of recombination occuring in recombination hotspots—short regions of around ~2 kb in length that have much higher recombination rates than ...
Fearnhead, Paul
core +1 more source
Journal of Basic Microbiology, EarlyView.ABSTRACT Polyhydroxybutyrate (PHB) is a natural polyester synthesized and stored intracellularly as cytoplasmic granules, serving as a carbon and energy reserve in certain bacteria. These granules are surrounded by a variety of proteins, including those directly involved in PHB metabolism—both in its synthesis and degradation—as well as a group of non ...
Jessica Ruiz‐Escobedo +8 more
wiley +1 more source