Results 201 to 210 of about 131,087 (254)
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Chromosomal rearrangement and carcinogenesis
Mutation Research/Reviews in Genetic Toxicology, 1982All carcinogens that have been thoroughly tested have been found to induce some kind of chromosomal rearrangement. Chromosomal rearrangements are associated with a variety of human and rodent cancers and are associated, with in vitro cell transformation.
M, Radman, P, Jeggo, R, Wagner
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Chromosomal rearrangements and speciation
Trends in Ecology & Evolution, 2001Several authors have proposed that speciation frequently occurs when a population becomes fixed for one or more chromosomal rearrangements that reduce fitness when they are heterozygous. This hypothesis has little theoretical support because mutations that cause a large reduction in fitness can be fixed through drift only in small, inbred populations ...
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Rearrangements and chromosomal evolution
Current Opinion in Genetics & Development, 2003Comparisons of the genome sequences of related species suggests varying patterns of chromosomal rearrangements in different evolutionary lineages. In this review, I focus on the quantitative characterization of rearrangement processes and discuss specific inventories that have been compiled to date.
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Complex Chromosomal Rearrangements
2018Abstract Complex chromosome rearrangements (CCRs) include most of the rearrangements that would not be accounted for as “straightforward” classical categories. They may be translocations with three or more segments involved; or they may comprise a mix of translocation and, for example, inversion.
David J. Amor, R. J. McKinlay Gardner
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Chromosome rearrangements in trypanosoma brucei
Cell, 1984We have studied chromosome rearrangements in T. brucei using pulsed field gradient gel electrophoresis to separate chromosome-sized DNA molecules. We detect size changes in a set of small chromosomes (200-700 kb) at a frequency of 10(-5) to 10(-6) per trypanosome division; this results in a radical difference in the size distribution of these ...
L H, Van der Ploeg +3 more
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Chromosomal rearrangements in bladder cancer
Urology, 1984Description des nouvelles techniques cytogenetiques d'etude des tumeurs solides des aberrations chromosomiques et des oncogenes dans les cellules cancereuses. Etude des rearrangements chromosomiques specifiques dans le cancer de la vessie et de l'importance pronostique du caryotype dans le cancer de la ...
Z, Gibas, A A, Sandberg
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Chromosome Rearrangements and Transposable Elements
Annual Review of Genetics, 2002▪ Abstract There has been limited corroboration to date for McClintock's vision of gene regulation by transposable elements (TEs), although her proposition on the origin of species by TE-induced complex chromosome reorganizations in combination with gene mutations, i.e., the involvement of both factors in relatively sudden formations of species in ...
Wolf-Ekkehard, Lonnig, Heinz, Saedler
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Structural Chromosome Rearrangements
1999The subject of structural chromosome rearrangements is an immense one, to which entire catalogs have been devoted. Indeed, there are theoretically an almost infinite number of ways in which chromosomes can reconfigure themselves from the normal 23-pair arrangement with which we are familiar.
Kathleen Kaiser-Rogers, Kathleen Rao
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Engineering chromosomal rearrangements in mice
Nature Reviews Genetics, 2001The combination of gene-targeting techniques in mouse embryonic stem cells and the Cre/loxP site-specific recombination system has resulted in the emergence of chromosomal-engineering technology in mice. This advance has opened up new opportunities for modelling human diseases that are associated with chromosomal rearrangements.
Y, Yu, A, Bradley
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2007
X chromosome rearrangements usually convey clinical manifestations in the hemizygous males and are, thus, readily ascertained. They are found in all parts of the X chromosome and are associated with more than 20 disorders. Some of the rearrangements are the results of homologous recombination between low-copy repeats (LCRs) on the X chromosome or ...
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X chromosome rearrangements usually convey clinical manifestations in the hemizygous males and are, thus, readily ascertained. They are found in all parts of the X chromosome and are associated with more than 20 disorders. Some of the rearrangements are the results of homologous recombination between low-copy repeats (LCRs) on the X chromosome or ...
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