Results 41 to 50 of about 116,201 (208)
Advanced Healthcare Materials, EarlyView.Zinc‐containing bioactive glass (ZnBG) promotes diabetic wound healing by regulating macrophage extracellular traps (METs). Specifically, ZnBG reduces oxidative stress and inhibits the PAD4 and NLRP3/caspase‐1/GSDMD signaling pathways, thereby suppressing MET formation.
RuiYang Sun +11 more
wiley +1 more source
A Disease Mechanism Underlying Bleeding in Wiskott-Aldrich Syndrome
Clinical Medicine Insights: Blood Disorders, 2008 The Wiskott-Aldrich Syndrome (WAS) is an × chromosome-linked immunodeficiency disorder. The most common symptom in WAS is bleeding. Several clinical investigations indicate that low platelet counts and defective platelet aggregation are the major causes ...
Shigeru Tsuboi
doaj +1 more source
Neurobiology of Disease, 1994 Benign Familial Neonatal Convulsions (BFNC) is an epileptic disorder with an autosomal dominant mode of transmission. It has been shown that about 80% of BFNC pedigrees are linked to a genetic defect on chromosome 20q13.3.
C. Beck +7 more
doaj +1 more source
Chromosome Transplantation: A Possible Approach to Treat Human X-linked Disorders
Molecular Therapy: Methods & Clinical Development, 2020 Many human genetic diseases are associated with gross mutations such as aneuploidies, deletions, duplications, or inversions. For these “structural” disorders, conventional gene therapy, based on viral vectors and/or on programmable nuclease-mediated ...
Marianna Paulis +12 more
doaj +1 more source
3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence
Advanced Healthcare Materials, EarlyView.Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes +11 more
wiley +1 more source
Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond
Frontiers in Genetics, 2013 Micronuclei (MN) are extranuclear bodies that contain damaged chromosome fragments and/or whole chromosomes that were not incorporated into the nucleus after cell division. MN can be induced by defects in the cell repair machinery and accumulation of DNA
Lidia eLuzhna +2 more
doaj +1 more source
DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis
Advanced Science, EarlyView.This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li +25 more
wiley +1 more source
Transcriptional profiling of regenerating embryonic mouse hearts
Genomics Data, 2016 The postnatal mammalian heart is considered a terminally differentiated organ unable to efficiently regenerate after injury. In contrast, we have recently shown a remarkable regenerative capacity of the prenatal heart using myocardial tissue mosaicism ...
Manuela Magarin +3 more
doaj +1 more source
Establishment of a mouse model with misregulated chromosome condensation due to defective Mcph1 function. [PDF]
PLoS ONE, 2010 Mutations in the human gene MCPH1 cause primary microcephaly associated with a unique cellular phenotype with premature chromosome condensation (PCC) in early G2 phase and delayed decondensation post-mitosis (PCC syndrome).
Marc Trimborn +20 more
doaj +1 more source
Structure and function of the visual pathway in demyelinating optic neuropathy [PDF]
, 2018 Introduction: Multiple sclerosis is a disabling disease with impact on the social, financial and occupational life of an individual. Diagnosis of Multiple sclerosis even with the McDonald criteria, sometimes can take many years, by which time the patient
Nayak, Devaki
core +1 more source