Results 11 to 20 of about 1,712,951 (299)

LARP7 family proteins have conserved function in telomerase assembly

Nature Communications, 2018
The telomerase holoenzyme is minimally composed of the reverse transcriptase and the RNA template. Here the authors identify Lar7 as a member of the full complex that helps to stabilise it and protect telomerase RNA from degradation.
Laura C. Collopy, Tracy L. Ware, Tomas Goncalves, Sunnvør í Kongsstovu, Qian Yang, Hanna Amelina, Corinne Pinder, Ala Alenazi, Vera Moiseeva, Siân R. Pearson, Christine A. Armstrong, Kazunori Tomita   +11 more
doaj   +1 more source

Dynamic epigenetic states of maize centromeres

Frontiers in Plant Science, 2015
The centromere is a specialized chromosomal region identified as the major constriction, upon which the kinetochore complex is formed, ensuring accurate chromosome orientation and segregation during cell division.
Yalin eLiu, Handong eSu, Jing eZhang, Yang eLiu, Fangpu eHan, James A. Birchler   +5 more
doaj   +1 more source

Full-length human dystrophin on human artificial chromosome compensates for mouse dystrophin deficiency in a Duchenne muscular dystrophy mouse model

Scientific Reports, 2023
Dystrophin maintains membrane integrity as a sarcolemmal protein. Dystrophin mutations lead to Duchenne muscular dystrophy, an X-linked recessive disorder.
Yosuke Hiramuki, Satoshi Abe, Narumi Uno, Kanako Kazuki, Shuta Takata, Hitomaru Miyamoto, Haruka Takayama, Kayoko Morimoto, Shoko Takehara, Mitsuhiko Osaki, Jun Tanihata, Shin’ichi Takeda, Kazuma Tomizuka, Mitsuo Oshimura, Yasuhiro Kazuki   +14 more
doaj   +1 more source

The Transmembrane Protein Semi1 Positions Gamete Nuclei for Reciprocal Fertilization in Tetrahymena

iScience, 2020
Summary: During sexual reproduction in the ciliate, Tetrahymena thermophila, cells of complementary mating type pair (“conjugate”) undergo simultaneous meiosis and fertilize each other.
Takahiko Akematsu, Rosalía Sánchez-Fernández, Felix Kosta, Elisabeth Holzer, Josef Loidl   +4 more
doaj   +1 more source

Telomere-to-telomere assembly of a complete human X chromosome

bioRxiv, 2019
After two decades of improvements, the current human reference genome (GRCh38) is the most accurate and complete vertebrate genome ever produced. However, no single chromosome has been finished end to end, and hundreds of unresolved gaps persist 1 , 2 ...
K. Miga, S. Koren, A. Rhie, Mitchell R. Vollger, Ariel Gershman, Andrey V. Bzikadze, Shelise Y. Brooks, Edmund Howe, David Porubsky, Glennis A. Logsdon, Valerie A. Schneider, T. Potapova, J. Wood, W. Chow, J. Armstrong, J. Fredrickson, E. Pak, Kristof Tigyi, Milinn Kremitzki, C. Markovic, V. Maduro, A. Dutra, G. Bouffard, Alexander M. Chang, Nancy F. Hansen, F. Thibaud-Nissen, A. Schmitt, Jon-Matthew Belton, Siddarth Selvaraj, M. Dennis, Daniela C. Soto, Ruta Sahasrabudhe, Gulhan Kaya, J. Quick, N. Loman, N. Holmes, M. Loose, U. Surti, R. Risques, Tina A. Graves Lindsay, R. Fulton, Ira M. Hall, B. Paten, K. Howe, W. Timp, Alice C. Young, J. Mullikin, P. Pevzner, J. Gerton, B. Sullivan, E. Eichler, A. Phillippy   +51 more
semanticscholar   +1 more source

PTBP1 enforces ATR-CHK1 signaling determining the potency of CDC7 inhibitors

iScience, 2023
Summary: CDC7 kinase is crucial for DNA replication initiation and fork processing. CDC7 inhibition mildly activates the ATR pathway, which further limits origin firing; however, to date the relationship between CDC7 and ATR remains controversial.
Anja Göder, Aisling Quinlan, Michael D. Rainey, Declan Bennett, Daniel Shamavu, Jacqueline Corso, Corrado Santocanale   +6 more
doaj   +1 more source

Ultrastructural details of mammalian chromosome architecture

bioRxiv, 2019
Over the past decade, 3C-related methods, complemented by increasingly detailed microscopic views of the nucleus, have provided unprecedented insights into chromosome folding in vivo.
Nils Krietenstein, S. Abraham, Sergey V. Venev, Nezar Abdennur, J. Gibcus, Tsung-Han Hsieh, K. Parsi, Liyan Yang, R. Maehr, L. Mirny, J. Dekker, O. Rando   +11 more
semanticscholar   +1 more source

Structure of the cohesin loader Scc2

Nature Communications, 2017
The cohesin complex maintains genome integrity by ensuring correct sister-chromatid segregation during mitosis and meiosis. Here, Chaoet al. present a pseudo-atomic model of the full-length Scc2–Scc4 cohesin loader complex and reveal key Scc2 surfaces ...
William C. H. Chao, Yasuto Murayama, Sofía Muñoz, Andrew W. Jones, Benjamin O. Wade, Andrew G. Purkiss, Xiao-Wen Hu, Aaron Borg, Ambrosius P. Snijders, Frank Uhlmann, Martin R. Singleton   +10 more
doaj   +1 more source

Y chromosome functions in mammalian spermatogenesis

eLife, 2021
The mammalian Y chromosome is critical for male sex determination and spermatogenesis. However, linking each Y gene to specific aspects of male reproduction has been challenging.
Jeremie Subrini, James Turner
doaj   +1 more source

Landscape of X chromosome inactivation across human tissues

Nature, 2016
X chromosome inactivation (XCI) silences transcription from one of the two X chromosomes in female mammalian cells to balance expression dosage between XX females and XY males. XCI is, however, incomplete in humans: up to one-third of X-chromosomal genes
T. Tukiainen, A. Villani, Angela Yen, M. Rivas, Jamie L. Marshall, R. Satija, Matthew Aguirre, L. Gauthier, M. Fleharty, Andrew W. Kirby, Beryl B. Cummings, Stephane E. Castel, K. Karczewski, F. Aguet, Andrea Byrnes, T. Lappalainen, A. Regev, K. Ardlie, N. Hacohen, D. MacArthur   +19 more
semanticscholar   +1 more source