Results 191 to 200 of about 1,311,035 (215)
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Cytogenetic and Genome Research, 2005
The term “chromosomics” is introduced to draw attention to the three-dimensional morphological changes in chromosomes that are essential elements in gene regulation. Chromosomics deals with the plasticity of chromosomes in relation to the three-dimensional positions of genes, which affect cell function in a developmental and tissue-specific manner ...
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The term “chromosomics” is introduced to draw attention to the three-dimensional morphological changes in chromosomes that are essential elements in gene regulation. Chromosomics deals with the plasticity of chromosomes in relation to the three-dimensional positions of genes, which affect cell function in a developmental and tissue-specific manner ...
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Journal of Cell Science, 1977
ABSTRACT 1986 was a celebration year for lampbrush chromosomes (LBCs), marked by the publication of Callan’s comprehensive and authoritative book on these structures. My commentary begins where Callan’s book ends, standing on tiptoe beside a large and rather neat assembly of well-established facts, principles and hypotheses, and trying ...
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ABSTRACT 1986 was a celebration year for lampbrush chromosomes (LBCs), marked by the publication of Callan’s comprehensive and authoritative book on these structures. My commentary begins where Callan’s book ends, standing on tiptoe beside a large and rather neat assembly of well-established facts, principles and hypotheses, and trying ...
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The human Y chromosome: a masculine chromosome
Current Opinion in Genetics & Development, 2006Once considered to be a genetic wasteland of no scientific interest beyond sex determination, the human Y chromosome has made a significant comeback in the past few decades and is currently implicated in multiple diseases, including spermatogenic failure - absent or very low levels of sperm production.
Michiel J. Noordam, Sjoerd Repping
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The Duplication of Chromosomes
Scientific American, 1958Chromosome duplication first of all requires the replication of the DNA. It is now clear that the replication of most if not all of the chromosomal DNA follows the scheme based on precise base pairing as originally proposed by Watson and Crick [50].
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Current Opinion in Genetics & Development, 2007
Eukariotic chromosomes occupy distinct territories in the cell nucleus. These territories intermingle little with other chromosomes. Nevertheless, several contacts between different chromosomal loci have been documented, a phenomenon called chromosome kissing.
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Eukariotic chromosomes occupy distinct territories in the cell nucleus. These territories intermingle little with other chromosomes. Nevertheless, several contacts between different chromosomal loci have been documented, a phenomenon called chromosome kissing.
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Chromosome Conformation Capture of Mitotic Chromosomes
2023Despite more than a century of intensive study of mitotic chromosomes, their three-dimensional organization remains enigmatic. The last decade established Hi-C as a method of choice for study of spatial genome-wide interactions. Although its utilization has been focused mainly on studying genomic interactions in interphase nuclei, the method can be ...
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Sex Chromosomes and Sex Chromosome Abnormalities
Clinics in Laboratory Medicine, 2011This article focuses on constitutional sex chromosome abnormalities detected by conventional cytogenetics and fluorescence in situ hybridization. The author discusses the two general classifications of abnormalities: numerical and structural. Also included are descriptions of unique aspects of X and Y chromosomes, technological advances in detection ...
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Ring-Chromosomes, Telocentric Chromosomes, Isochromosomes, and B Chromosomes
1980This chapter is a continuation of the discussion of unusual chromosome types. As mentioned before, the term “unusual” in this connection is a relative term. We very often have a certain concept of things, and whatever deviates from this concept we call “unusual”. Because ring-chromosomes, telocentric chromosomes, isochromosomes, or B chromosomes differ
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Chromosome structure in relation to the chromosome cycle
The Botanical Review, 1936The observational and experimental evidence reviewed here indicates that the chromonema is a fundamental and permanent component of the chromosome. As a structure persistent through the mitotic cycle, it provides a mechanism for the maintenance of the linear order of the genes, its chromomeric organization furnishing morphological evidence of its ...
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