Results 251 to 260 of about 1,598,920 (365)

Origins, Dispersal, and Impact: Bidirectional Introgression Between Chinese and European Pig Populations

open access: yesAdvanced Science, EarlyView.
This study investigates bidirectional introgression between Chinese and European pig populations, revealing 3558 introgressed genomic segments and 30 structural variations. Analysis of the BMP2 region suggests its role in body size enhancement. By integrating ancient and modern genomes, the study highlights the impact of introgression on genetic ...
Yibin Qiu   +19 more
wiley   +1 more source

Nuclear‐Localized BCKDK Facilitates Homologous Recombination Repair to Support Breast Cancer Progression and Therapy Resistance

open access: yesAdvanced Science, EarlyView.
Under DNA damage, tumor cells rely on efficient DNA repair for survival and therapy resistance. This study has demonstrated that BCKDK localizes to breast cancer cell nuclei, where it binds to and phosphorylates RNF8, thereby blocking ubiquitin‐mediated degradation of RAD51 and enhancing HRR. A selective BCKDK inhibitor synergizes with clinical agents,
Haiying Liu   +12 more
wiley   +1 more source

TRANSLOCATIONS IN MAIZE INVOLVING CHROMOSOME 4 [PDF]

open access: bronze, 1955
Edgar Anderson   +2 more
openalex   +1 more source

Single‐Cell Sequencing‐Guided Annotation of Rare Tumor Cells for Deep Learning‐Based Cytopathologic Diagnosis of Early Lung Cancer

open access: yesAdvanced Science, EarlyView.
This study presents an innovative method to generate high‐quality, objectively annotated cytology datasets without relying on expert involvement. Large‐scale single‐cell DNA sequencing is used as an objective ground truth of cell annotation for generating an accurate, unbiased dataset of exfoliated tumor cells from bronchoalveolar lavage cytology ...
Yichun Zhao   +10 more
wiley   +1 more source

Chromosome‐Level Genome Assembly of the Leafcutter Bee Megachile rotundata Reveals Its Ecological Adaptation and Pollination Biology

open access: yesAdvanced Science, EarlyView.
The genome of Megachile rotundata, an extensively managed solitary pollination bee species, has been sequenced, covering 280.68 Mb and predicting 10 701 genes. The study reveals significant expansions of the Toll gene family and their abundant expression in diapause prepupae, highlighting enhanced immune responses during diapause. This genome serves as
Rangjun Shi   +8 more
wiley   +1 more source

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