Results 271 to 280 of about 2,472,873 (391)

Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome

Advanced Science, EarlyView.
This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha, Kyle L. MacQuarrie, Marcelo Carignano, Cody L. Dunton, Ruyi Gong, Joe Ibarra, Lucas M. Carter, Wing Shun Li, Rikkert Nap, Parambir S. Dulai, Igal Szleifer, Vadim Backman   +11 more
wiley   +1 more source

The maize B chromosome shapes the transcriptome throughout the entire plant life cycle. [PDF]

J Exp Bot
Hloušková L, Tulpová Z, Svačina R, Holušová K, Cápal P, Navrátilová P, Karafiátová M, Bartoš J.   +7 more
europepmc   +1 more source

PF775 MONOSOMY 7 ALONE OR WITH OTHER CHROMOSOMAL ABNORMALITIES SIGNIFICANTLY AFFECT SURVIVAL OF SECONDARY AML PATIENTS TREATED WITH ALLOGENEIC- SCT

, 2019
Mona Hassanein, Mahmoud Aljurf, SG Ahmed, Amr Hanbali, Fahad Almohareb, Fatima Essamaldin Altahir Mohamed Alsharif, Ali Alahmari, Hazzaa Alzahrani, Marwan Shaheen, Saud Alhayli, Naeem Chaudhri, Wafaa M. Rashed, Feras Alfraih, Riad El Fakih, H. Sharhrukh   +14 more
openalex   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Optimized dicentric chromosome dose-response curves with centromere probes improve low-dose radiation biodosimetry. [PDF]

Sci Rep
Jeong MH, Choi HS, Jeong SK, Kang YR, Lee CG, Kim HJ, Kye YU, Baek JH, Park MT, Kim JS, Oh SJ, Jo WS.   +11 more
europepmc   +1 more source

Single‐Nucleus Multi‐Omics Reveals Hypoxia‐Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You, Jaewoo Park, Jung Yeon Jang, Junho Noh, Jaehyun Lee, Geunho Kwon, Myeong Sang Yu, Yoo‐Sam Chung, Seung‐Jun Lee, Keunsoo Kang, Jihwan Park, Ji Heui Kim, Kyuho Kang   +12 more
wiley   +1 more source

Sex differences in crossover interference in house mice. [PDF]

G3 (Bethesda)
Morgan AP.
europepmc   +1 more source

The Frequency of Chromosomal Abnormalities in Men With Azoospermia and Oligoasthenoteratozoospermia: a Preliminary Study

, 1998
Cüneyt Tüzün
openalex   +1 more source

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

A molecular cytogenetic perspective on chromosome biology and crop improvement. [PDF]

Plant Genome
Gill BS.
europepmc   +1 more source