Results 21 to 30 of about 1,806,540 (343)
Chromosome Structure: Coiling up chromosomes [PDF]
Current Biology, 1995 The mechanism by which eukaryotic chromosomes condense as cells enter mitosis has long been inaccessible to molecular biologists. An important clue has now been provided by a ubiquitous protein family, the SMCs.
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The Transmembrane Protein Semi1 Positions Gamete Nuclei for Reciprocal Fertilization in Tetrahymena
iScience, 2020 Summary: During sexual reproduction in the ciliate, Tetrahymena thermophila, cells of complementary mating type pair (“conjugate”) undergo simultaneous meiosis and fertilize each other.
Takahiko Akematsu +4 more
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Physical mapping integrated with syntenic analysis to characterize the gene space of the long arm of wheat chromosome 1A [PDF]
, 2013 Background: Bread wheat (Triticum aestivum L.) is one of the most important crops worldwide and its production faces pressing challenges, the solution of which demands genome information. However, the large, highly repetitive hexaploid wheat genome has
Akpınar, Bala Anı +15 more
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The Origin of a New Sex Chromosome by Introgression between Two Stickleback Fishes. [PDF]
, 2019 Introgression is increasingly recognized as a source of genetic diversity that fuels adaptation. Its role in the evolution of sex chromosomes, however, is not well known. Here, we confirm the hypothesis that the Y chromosome in the ninespine stickleback,
Abbott +78 more
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Seminars in Cell & Developmental Biology, 2021 Our understanding of the structure and function of mitotic chromosomes has come a long way since these iconic objects were first recognized more than 140 years ago, though many details remain to be elucidated. In this chapter, we start with the early history of chromosome studies and then describe the path that led to our current understanding of the ...
James R. Paulson +3 more
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PTBP1 enforces ATR-CHK1 signaling determining the potency of CDC7 inhibitors
iScience, 2023 Summary: CDC7 kinase is crucial for DNA replication initiation and fork processing. CDC7 inhibition mildly activates the ATR pathway, which further limits origin firing; however, to date the relationship between CDC7 and ATR remains controversial.
Anja Göder +6 more
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Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation
eLife, 2021 The Rad53 DNA checkpoint protein kinase plays multiple roles in the budding yeast cell response to DNA replication stress. Key amongst these is its enigmatic role in safeguarding DNA replication forks.
Allison W McClure, John FX Diffley
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A conserved filamentous assembly underlies the structure of the meiotic chromosome axis. [PDF]
, 2019 The meiotic chromosome axis plays key roles in meiotic chromosome organization and recombination, yet the underlying protein components of this structure are highly diverged.
Caballero, Iracema +10 more
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Structure of the cohesin loader Scc2
Nature Communications, 2017 The cohesin complex maintains genome integrity by ensuring correct sister-chromatid segregation during mitosis and meiosis. Here, Chaoet al. present a pseudo-atomic model of the full-length Scc2–Scc4 cohesin loader complex and reveal key Scc2 surfaces ...
William C. H. Chao +10 more
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Y chromosome functions in mammalian spermatogenesis
eLife, 2021 The mammalian Y chromosome is critical for male sex determination and spermatogenesis. However, linking each Y gene to specific aspects of male reproduction has been challenging.
Jeremie Subrini, James Turner
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