Results 51 to 60 of about 1,768,096 (341)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Rejuvenation of human mesenchymal stem cells using a nonintegrative and conditionally removable Sendai virus vector

Scientific Reports
Human mesenchymal stem cells (hMSCs) with extended lifespan and differentiation potential that can recapitulate in vivo characteristics could significantly contribute to basic research, drug development, and cell therapy.
Mitsuo Oshimura, Toshiaki Tabata, Narumi Uno, Shuta Takata, Genki Hichiwa, Iori Kanazawa, Takeshi Endo, Kazuhisa Honma, Yayan Wang, Kanako Kazuki, Haochen Tu, Yuichi Iida, Satoshi Abe, Yasuhiro Kazuki   +13 more
doaj   +1 more source

Large chromosomal structural variations between M. acuminata and M balbisiana and their consequences on chromosome recombination and segregation in a AAAB polyploidy context [PDF]

, 2017
Many banana cultivars are triploid interspecific hybrids between M. acuminata (Genome A, 2n=22) and M. balbisiana (Genome B, 2n=22). They included the important group of Plantain cooking bananas classified as AAB.
Baurens, Franc-Christophe, D'Hont, Angélique, Habas, Rémy, Martin, Guillaume, Njembele, J. Célestin, Ricci, Sébastien, Rouard, Mathieu, Salmon, Frédéric   +7 more
core  

Chromosome Segregation Is Biased by Kinetochore Size [PDF]

, 2018
Chromosome missegregation during mitosis or meiosis is a hallmark of cancer and the main cause of prenatal death in humans. The gain or loss of specific chromosomes is thought to be random, with cell viability being essentially determined by selection ...
Aguiar, P, Almeida, A C, Damas, J, Drpic, D, Khodjakov, A, Larkin, D M, Lewin, H A, Maiato, H, Renda, F   +8 more
core   +1 more source

Chromosomics: Bridging the Gap between Genomes and Chromosomes [PDF]

Genes, 2019
The recent advances in DNA sequencing technology are enabling a rapid increase in the number of genomes being sequenced. However, many fundamental questions in genome biology remain unanswered, because sequence data alone is unable to provide insight into how the genome is organised into chromosomes, the position and interaction of those chromosomes in
Ikuo Miura, Lukáš Kratochvíl, Kichi Fukui, Janine E. Deakin, Mark D. B. Eldridge, Tariq Ezaz, Darren K. Griffin, Kornsorn Srikulnath, Marcelo de Bello Cioffi, Michail Rovatsos, Erik Wapstra, Aurora Ruiz-Herrera, Sally Potter, Sally Potter, Frank Grützner, Rachel J. O’Neill, Jennifer A. Marshall Graves, Jennifer A. Marshall Graves   +17 more
openaire   +7 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Centromere function in asymmetric cell division in Drosophila female and male germline stem cells

Open Biology, 2021
The centromere is the constricted chromosomal region required for the correct separation of the genetic material at cell division. The kinetochore protein complex assembles at the centromere and captures microtubules emanating from the centrosome to ...
Antje M. Kochendoerfer, Federica Modafferi, Elaine M. Dunleavy   +2 more
doaj   +1 more source

Chromatin and chromosomes

Molecular Biology of the Cell, 2011
Recent advances in our understanding of chromosome behavior have been made possible by the development of cutting-edge cytological and molecular techniques. Presentations in this Minisymposium applied these techniques to a diverse set of topics. Sarah Elgin (Washington University) described her lab’s studies on the 1360 transposable element in ...
Lori L. Wallrath, David M. Gilbert
openaire   +3 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Control of Smc Coiled Coil Architecture by the ATPase Heads Facilitates Targeting to Chromosomal ParB/parS and Release onto Flanking DNA

Cell Reports, 2016
Smc/ScpAB promotes chromosome segregation in prokaryotes, presumably by compacting and resolving nascent sister chromosomes. The underlying mechanisms, however, are poorly understood.
Anita Minnen, Frank Bürmann, Larissa Wilhelm, Anna Anchimiuk, Marie-Laure Diebold-Durand, Stephan Gruber   +5 more
doaj   +1 more source