Results 61 to 70 of about 1,598,920 (365)

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Rejuvenation of human mesenchymal stem cells using a nonintegrative and conditionally removable Sendai virus vector

Scientific Reports
Human mesenchymal stem cells (hMSCs) with extended lifespan and differentiation potential that can recapitulate in vivo characteristics could significantly contribute to basic research, drug development, and cell therapy.
Mitsuo Oshimura, Toshiaki Tabata, Narumi Uno, Shuta Takata, Genki Hichiwa, Iori Kanazawa, Takeshi Endo, Kazuhisa Honma, Yayan Wang, Kanako Kazuki, Haochen Tu, Yuichi Iida, Satoshi Abe, Yasuhiro Kazuki   +13 more
doaj   +1 more source

Control of Smc Coiled Coil Architecture by the ATPase Heads Facilitates Targeting to Chromosomal ParB/parS and Release onto Flanking DNA

Cell Reports, 2016
Smc/ScpAB promotes chromosome segregation in prokaryotes, presumably by compacting and resolving nascent sister chromosomes. The underlying mechanisms, however, are poorly understood.
Anita Minnen, Frank Bürmann, Larissa Wilhelm, Anna Anchimiuk, Marie-Laure Diebold-Durand, Stephan Gruber   +5 more
doaj   +1 more source

Unified theory of human genome reveals a constrained spatial chromosomal arrangement in interphase nuclei [PDF]

, 2015
We investigate a densely packed, non-random arrangement of forty-six chromosomes (46,XY) in human nuclei. Here, we model systems-level chromosomal crosstalk by unifying intrinsic parameters (chromosomal length and number of genes) across all pairs of chromosomes in the genome to derive an extrinsic parameter called effective gene density.
arxiv   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes

Nature Communications, 2020
Oocyte meiosis must achieve spindle bipolarization without predefined spatial cues. Yoshida et al. demonstrate that spindle bipolarization during meiosis I in mouse oocytes requires kinetochores to prevent chromosome segregation errors, a phenomenon that
Shuhei Yoshida, Sui Nishiyama, Lisa Lister, Shu Hashimoto, Tappei Mishina, Aurélien Courtois, Hirohisa Kyogoku, Takaya Abe, Aki Shiraishi, Meenakshi Choudhary, Yoshiharu Nakaoka, Mary Herbert, Tomoya S. Kitajima   +12 more
doaj   +1 more source

Large chromosomal structural variations between M. acuminata and M balbisiana and their consequences on chromosome recombination and segregation in a AAAB polyploidy context [PDF]

, 2017
Many banana cultivars are triploid interspecific hybrids between M. acuminata (Genome A, 2n=22) and M. balbisiana (Genome B, 2n=22). They included the important group of Plantain cooking bananas classified as AAB.
Baurens, Franc-Christophe, D'Hont, Angélique, Habas, Rémy, Martin, Guillaume, Njembele, J. Célestin, Ricci, Sébastien, Rouard, Mathieu, Salmon, Frédéric   +7 more
core  

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Chromatin and chromosomes

Molecular Biology of the Cell, 2011
Recent advances in our understanding of chromosome behavior have been made possible by the development of cutting-edge cytological and molecular techniques. Presentations in this Minisymposium applied these techniques to a diverse set of topics. Sarah Elgin (Washington University) described her lab’s studies on the 1360 transposable element in ...
Lori L. Wallrath, David M. Gilbert
openaire   +3 more sources

A Robust Framework of Chromosome Straightening with ViT-Patch GAN [PDF]

arXiv, 2022
Chromosomes carry the genetic information of humans. They exhibit non-rigid and non-articulated nature with varying degrees of curvature. Chromosome straightening is an important step for subsequent karyotype construction, pathological diagnosis and cytogenetic map development.
arxiv