Results 251 to 260 of about 1,193,636 (302)

Molecular cytogenetic resources specific for chromosome 12

American Journal of Medical Genetics, 1999
We have generated a panel of 20 somatic cell hybrids retaining fragments of human chromosome 12. Each hybrid was characterized cytogenetically by reverse fluorescence in situ hybridization (FISH) and molecularly by 24 sequence tagged sites (STSs) spaced evenly along the chromosome.
VIGGIANO, Luigi, STORLAZZI, CLELIA TIZIANA, ARCHIDIACONO, Nicoletta, ROCCHI, Mariano, Miolla V., Ricco A., Pennacchia M., Fratello A., Mancini M., Marzella R.   +9 more
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Familial occurrence of chromosome 7/12 translocation

Clinical Genetics, 1980
A new balanced autosomal translocation, t(7;12) (p12;p13), was found in a high genetic risk family in which the mother is a translocation carrier. She had 12 pregnancies, six of which were terminated during the first trimester by spontaneous abortions.
P M, Ming, R, Parker, D M, Goodner
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Chromosomes 12 and 16 workshop

American Journal of Medical Genetics, 1999
Recent linkage results independently derived from a large French Canadian pedigree and Danish kindreds coupled with supportive data from other studies provide compelling evidence for a bipolar disorder susceptibility locus on chromosome 12q23-q24. The idea is further strengthened by the finding that Darier's disease, which maps to this region, has been
Sevilla D. Detera‐Wadleigh, N. Barden, N. Craddock, H. Ewald, T. Foroud, J. Kelsoe, A. McQuillin   +6 more
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12 Y-chromosomal STR haplotypes in Japanese

Forensic Science International, 2006
Haplotypes and allele frequencies of 12 Y-STRs were examined in a population sample of 381 Japanese male volunteers. A total of 315 haplotypes were identified, of which 288 haplotypes were unique, and 18, three, three, two, one and one were found in two, three, four, five, eight and 18 individuals, respectively. Total gene diversity was 0.997.
Masaki, Hashiyada, Toshio, Nagashima, Yukio, Itakura, Jun, Sakai, Yoshimasa, Kanawaku, Jun, Kanetake, Masayuki, Nata, Masato, Funayama   +7 more
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Inversions of chromosome 12 in human malignancies

Cancer Genetics and Cytogenetics, 1987
We present four cases with a malignant hematologic disorder and an inversion (peri- or paracentric) involving chromosome #12. Two cases of myelodysplastic syndrome showed an identical acquired pericentric inv(12)(p12q23). The pertinent literature on constitutional and acquired inversions of chromosome #12 has been revised.
I, Larripa, C, Mecucci, N, Testoni, A, Bosly, C, Doyen, H, Tytgat, H, Van den Berghe   +6 more
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Chromosome 12 and late-onset Alzheimer's disease

Neuroscience Letters, 2001
Alzheimer's disease is a complex neurodegenerative disorder, characterized by cognitive decline and distinctive neuropathology. Using large extended families with multiple affected, we found that three markers on chromosome 12 were linked with late-onset Alzheimer's disease. These markers were downstream from the gene for alpha-2 macroglobulin.
S E, Poduslo, X, Yin
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Involvement of Chromosome 12 in Uterine Leiomyoma

1994
Leiomyomas are the most common benign mesenchymal tumors of the uterus. They occur mostly in women older than 30 years, less frequently after menopause, and very rarely below the age of 18. Their pathogenesis is not clearly understood, but a role for sex steroid hormones is likely since they increase in size during pregnancy or after administration of ...
VANNI, ROBERTA, Dal Cin P.
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Insights from Chromosome-Centric Mapping of Disease-Associated Genes: Chromosome 12 Perspective

Journal of Proteome Research, 2015
In line with the aims of the Chromosome-based Human Proteome Project and the Biology/Disease-based Human Proteome Project, we have been studying differentially expressed transcripts and proteins in gliomas—the most prevalent primary brain tumors. Here, we present a perspective on important insights from this analysis in terms of their co-expression, co-
Savita, Jayaram, Manoj Kumar, Gupta, Bhadravathi Marigowda, Shivakumar, Madankumar, Ghatge, Ankit, Sharma, Rajani Kanth, Vangala, Ravi, Sirdeshmukh   +6 more
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Ring chromosome 12 and latent centromeres

Cytogenetic and Genome Research, 1980
A ring 12 chromosome was found in a male child with minor phenotypic alterations. No obvious loss of chromosome material was detected. Since there is no other case of a ring 12 in the literature, it was not possible to determine whether the phenotype was due to (invisible) terminal deletions or to karyotypic variation.
ZUFFARDI, ORSETTA, DANESINO, CESARE, Poloni L, Pavesi F, Bianchi C, Gargantini L.   +5 more
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A BrdU-requiring fragile site on chromosome 12

Human Genetics, 1988
A BrdU-requiring fragile site, fra(12)(q24.2), on human chromosome 12 of some individuals is reported. This fragile site is inherited in a Mendelian codominant fashion and does not seem to be associated with any physical or mental abnormality in carriers.
I, Voiculescu, C, Hausmann, G, Wolff, E, Back   +3 more
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