Results 61 to 70 of about 1,193,636 (302)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Molecular Detection of Genes Related to Antimicrobial Resistance harbored on chromosome by PCR assay in P. aeruginosa [PDF]

Basrah Journal of Veterinary Research
Forty-two typical P. aeruginosa strains were chosen, and Eight antibiotic-resistance genes linked to a spontaneous outbreak of the bacteria were analyzed (the same strains that were tested for the antimicrobial susceptibility). The findings revealed that
Tamadhar Al-tememe, Basil Abbas
doaj   +1 more source

Detection of Hereditary 1,25-Hydroxyvitamin D-Resistant Rickets Caused by Uniparental Disomy of Chromosome 12 Using Genome-Wide Single Nucleotide Polymorphism Array. [PDF]

PLoS ONE, 2015
Hereditary 1,25-dihydroxyvitamin D-resistant rickets (HVDRR) is an autosomal recessive disease caused by biallelic mutations in the vitamin D receptor (VDR) gene.
Mayuko Tamura, Tsuyoshi Isojima, Minae Kawashima, Hideki Yoshida, Keiko Yamamoto, Taichi Kitaoka, Noriyuki Namba, Akira Oka, Keiichi Ozono, Katsushi Tokunaga, Sachiko Kitanaka   +10 more
doaj   +1 more source

Association Mapping for Common Bunt Resistance in Wheat [PDF]

, 2013
Common bunt, caused by Tilletia caries and T. foetida, is a fungal disease of wheat world wide. Infection, occurring via seed borne teliospores, is generally controlled by the application of seed treatments prior to sowing.
Backes, Gunter, Borgen, Anders, Rasmussen, Søren K., Steffan, Philipp   +3 more
core  

Multiple QTL-effects of wheat Gpc-B1 locus on grain protein and micronutrient concentrations [PDF]

, 2007
Micronutrient malnutrition afflicts over three billion peopleworldwide and the numbers are continuously increasing. Developing genetically micronutrientenriched cereals, which are the predominant source of human dietary, is essential to alleviate ...
Asher CJ, Black MM, Cakmak I, Cakmak I, Cantrell RG, Chee PW, Feil B, Feil B, Gregorio GB, Holtz C, Jones JB, Joppa LR, Joppa LR, McFadden ES, Nevo E, O'Brien TP, Peterson CV, Raboy V, SAS Institute, Smith VR, Steiger DK, Uauy C, Welch RM   +22 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Mouse ZGRF1 helicase facilitates DNA repair and maintains efficient fertility

Heliyon
The recently characterised human ZGRF1 helicase promotes genomic stability by facilitating DNA interstrand crosslink repair. In its absence, human cells exhibit greater sensitivity towards anti-cancer drugs such as mitomycin C and camptothecin. Moreover,
Ernest Wee Kiat Lim, Smaragda Kompocholi, André Brannvoll, K. Stine V. Bagge, Jennifer R. Gruhn, Javier Martin-Gonzalez, Eliene Albers, Ian D. Hickson, Andrés López-Contreras, Michael Lisby   +9 more
doaj   +1 more source

The karyotype of Adenia and the origin of the base number x = 12 in Passifloroideae (Passifloraceae)

Anais da Academia Brasileira de Ciências, 2021
Adenia is an Old World genus of Passifloroideae closely related to Passiflora. The two genera comprise the large majority of Passifloroideae species, although most studies are concentrated on Passiflora.
NATONIEL FRANKLIN DE MELO, MARCELO GUERRA   +1 more
doaj   +1 more source

Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families. [PDF]

, 2014
BackgroundThe age at onset of alcohol dependence (AD) is a critical moderator of genetic associations for alcohol dependence. The present study evaluated whether single nucleotide polymorphisms (SNPs) can influence the age at onset of AD in large high ...
Agrawal, Arpana, Almasy, Laura, Bertelsen, Sarah, Bierut, Laura, Bucholz, Kathleen, Budde, John, Dick, Danielle M, Edenberg, Howard J, Foroud, Tatiana, Goate, Alison, Harari, Oscar, Hesselbrock, Victor, Hinrichs, Anthony L, Kapoor, Manav, Kramer, John, Le, Nhung, Nurnberger, John I, Porjesz, Bernice, Rice, John, Schuckit, Marc, Tischfield, Jay, Wang, Jen-Chyong, Wetherill, Leah, Xiaoling, Xuei   +23 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source