Advanced Functional Materials, EarlyView.A biofabricated 3D in vitro model recapitulating endochondral ossification (ECO) is described, mimicking the steps from condensation to chondrogenesis and hypertrophy, culminating with vascularization of the hypertrophic construct. As a model proof of concept application, Ewing Sarcoma cells are seeded in the model, showing modifications in their ...
Maria Vittoria Colombo +13 more
wiley +1 more source
Submicroscopic aberrations of chromosome 16 in prenatal diagnosis
Molecular Cytogenetics, 2019 Background Nearly 9.89% of chromosome 16 consists of segmental duplications, which makes it prone to non-homologous recombination. The present study aimed to investigate the incidence and perinatal characteristics of submicroscopic chromosome 16 ...
Xiaoqing Wu +9 more
doaj +1 more source
Background Level of Unstable Chromosome Aberrations in the Kazakhstan Population: A Human Biomonitoring Study. [PDF]
Int J Environ Res Public Health, 2022 Kenzhina LB +10 more
europepmc +1 more source
Versatile Cell Penetrating Peptide for Multimodal CRISPR Gene Editing in Primary Stem Cells
Advanced Functional Materials, EarlyView.CRISPR machinery in diverse molecular formats (DNA, RNA, and ribonucleic protein) is complexed into nanoparticles with the cell‐friendly arginine‐alanine‐leucine‐alanine (RALA) cell‐penetrating peptide. Nanoparticles are delivered to primary mesenchymal stem cells ex vivo or locally in vivo to facilitate multimodal CRISPR gene editing. This RALA‐CRISPR
Joshua P. Graham +9 more
wiley +1 more source
The Relationship between Screening Markers in the First Trimester of Pregnancy and Chromosome Aberrations. [PDF]
Int J Prev Med, 2022 Mirsafaie M +2 more
europepmc +1 more source
X-RAY AND ULTRAVIOLET STUDIES ON POLLEN TUBE CHROMOSOMES. I. THE EFFECT OF ULTRAVIOLET (2537 Å) ON X-RAY-INDUCED CHROMOSOMAL ABERRATIONS [PDF]
, 1944 C. P. Swanson
openalex +1 more source
3D Multicellular Scaffold Based Model for Advancing Bone Disorder Research
Advanced Functional Materials, EarlyView.A scalable 3D multicellular in vitro bone model engineered by integrating osteoblasts, osteoclasts, and endothelial cells on biodegradable scaffolds. The system recapitulates key features of human bone remodeling and disease pathology. As a proof of concept, the model mimics osteogenesis imperfecta, demonstrating its potential as a physiologically ...
Gali Guterman‐Ram +5 more
wiley +1 more source
A cloud-based resource for genome coordinate-based exploration and large-scale analysis of chromosome aberrations and gene fusions in cancer. [PDF]
Genes Chromosomes Cancer, 2023 Wang J +12 more
europepmc +1 more source
FREQUENCY OF CHROMOSOME ABERRATIONS PRODUCED BY FRACTIONAL DOSES OF X-RAYS IN TRADESCANTIA [PDF]
, 1954 Dale M. Steffensen, T. J. Arnason
openalex +1 more source
Self‐Assembling Multi‐Antigen T Cell Hybridizers for Precision Immunotherapy of Multiple Myeloma
Advanced Healthcare Materials, EarlyView.A novel modular T‐cell engager platform, MATCH, is developed for personalized multiple myeloma therapy. MATCH uses complementary oligonucleotide‐linked Fab’ fragments to enable flexible targeting of MM antigens and controlled T‐cell activation. The system shows potent, antigen‐specific cytotoxicity in vitro and in vivo, highlighting its potential for ...
Shannuo Li +8 more
wiley +1 more source