Results 121 to 130 of about 55,436 (218)

Genome Mining Enabled by Biosynthetic Characterization Uncovers a Class of Benzoxazolinate‐Containing Natural Products in Diverse Bacteria

Angewandte Chemie, Volume 134, Issue 51, December 19, 2022., 2022
Benzoxazolinate is a rare bis‐heterocyclic moiety that interacts with proteins and DNA. It was found that a putative acyl AMP‐ligase mediates the last cyclization step to afford benzoxazolinate. The enzyme was then used as a probe for genome mining, which led to the discovery of a new class of benzoxazolinate‐containing compounds in diverse bacteria ...
Yi‐Ming Shi, Jan J. Crames, Laura Czech, Kenan A. J. Bozhüyük, Yan‐Ni Shi, Merle Hirschmann, Stefanie Lamberth, Peter Claus, Nicole Paczia, Christian Rückert, Jörn Kalinowski, Gert Bange, Helge B. Bode   +12 more
wiley   +2 more sources

Systematic analysis and evaluation of chromosome aberrations in major birth defects associated with infertility. [PDF]

Intractable Rare Dis Res
Lan F, Chen Z, Lin X.
europepmc   +1 more source

Enhancer Extrachromosomal Circular DNA ANKRD28 Elicits Drug Resistance via POU2F2‐Mediated Transcriptional Network in Multiple Myeloma

Advanced Science, EarlyView.
Enhancer eccANKRD28‐manipulated MM cells have been demonstrated to facilitate drug resistance and promote MM progression by activating the key transcription factor, POU2F2. POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes (IRF4, JUNB, IKZF3, et al.
Binzhen Chen, Jia Liu, Yaoxin Zhang, Changming Shi, Di Zhu, Guoqiang Zhang, Fei Xiao, Lu Zhong, Minyue Zhang, Lai Guan Ng, Honghui Huang, Tingting Lu, Jian Hou   +12 more
wiley   +1 more source

Single‐Cell Analysis Clarifies Pathological Heterogeneity in Tenosynovial Giant Cell Tumor and Identifies Biomarkers for Predicting Disease Recurrence

Advanced Science, EarlyView.
MP3 tumor cells, a specific subpopulation of tumor cells in D‐TGCT, regulated the differentiation of CD34+ Fbs into MMP3+ Fbs and APOE+ Fbs through COL6A3 − (ITGAV + ITGB8) interaction. APOE+ Fbs activated IL‐1B+CCL20+ Mφs through the CXCL12/CXCR4 axis. IL‐1B+CCL20+ Mφs and MMP3+ Fbs participated in the local invasion of D‐TGCT.
Yubin Xie, Chen Chen, Fei Wu, Yiman Peng, Jing Su, Yang Zhao, Hongjie Huang, Zhong Alan Li, Yin Pei, Wencui Li, Yi He, Tianchen Xue, Chenxi Cao, Sui Peng, Xin Zhang, Weidong Song   +15 more
wiley   +1 more source

Combination of QF-PCR and aCGH is an efficient diagnostic strategy for the detection of chromosome aberrations in recurrent miscarriage. [PDF]

Mol Genet Genomic Med, 2019
Lovrečić L, Pereza N, Jaklič H, Ostojić S, Peterlin B.   +4 more
europepmc   +1 more source

The Hypoxia‐Associated High‐Risk Cell Subpopulation Distinctly Enhances the Progression of Glioma

Advanced Science, EarlyView.
This study suggests the potential roles of a novel hypoxia‐associated CDC20+KIF20A+PTTG1+ cell subpopulation in glioma progression. This high‐risk glioma cell subpopulation is therapeutically vulnerable to glioma progression and may play important roles in glioma standard‐of‐care therapeutic resistance.
Quan Wan, Xuechao Wu, Jinxu Zhou, Weiqi Wu, Yuanliang Cao, Cuiping Sun, Zheng Li, Zhicheng Gong, Hong Tang, Qilin Li, Junsheng Chu, Qing Wang, Kaisa Cui, Xiaojie Lu   +13 more
wiley   +1 more source

Increased Chromosome Aberrations in Cells Exposed Simultaneously to Simulated Microgravity and Radiation. [PDF]

Int J Mol Sci, 2018
Hada M, Ikeda H, Rhone JR, Beitman AJ, Plante I, Souda H, Yoshida Y, Held KD, Fujiwara K, Saganti PB, Takahashi A.   +10 more
europepmc   +1 more source

Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure‐Based Virtual Screening

Advanced Science, EarlyView.
Pancreatic cancer is a highly aggressive malignancy with limited treatment options. CLK4 regulates alternative splicing, contributing to cancer progression. This study establishes a computational model to identify CLK4 inhibitors, leading to compound 150441 (IC50: 21.4 nm).
Chun‐Lin Yang, Yi‐Wen Wu, Huang‐Ju Tu, Yun‐Hsuan Yeh, Tony Eight Lin, Tzu‐Ying Sung, Mu‐Chun Li, Shih‐Chung Yen, Jui‐Hua Hsieh, Ming‐Chin Yu, Sen‐Yung Hsieh, Hsing‐Pang Hsieh, Shiow‐Lin Pan, Kai‐Cheng Hsu   +13 more
wiley   +1 more source

Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT examinations in eight patients. [PDF]

J Radiat Res, 2019
Abe Y, Noji H, Miura T, Sugai M, Kurosu Y, Ujiie R, Tsuyama N, Yanagi A, Yanai Y, Ohba T, Ishikawa T, Kamiya K, Yoshida MA, Sakai A.   +13 more
europepmc   +1 more source

Unveiling Multi‐Scale Architectural Features in Single‐Cell Hi‐C Data Using scCAFE

Advanced Science, EarlyView.
scCAFE is a deep learning framework designed to identify multi‐scale 3D genome architectural features from single‐cell Hi‐C data without dense imputation. It predicts chromatin loops, TAD‐like domains, and A/B compartments, enabling efficient characterization of organization at the single‐cell level. scCAFE also identifies marker loop anchors, offering
Fuzhou Wang, Jiecong Lin, Hamid Alinejad‐Rokny, Wenjing Ma, Lingkuan Meng, Lei Huang, Jixiang Yu, Nanjun Chen, Yuchen Wang, Zhongyu Yao, Weidun Xie, Ka‐Chun Wong, Xiangtao Li   +12 more
wiley   +1 more source