Results 51 to 60 of about 812,203 (315)

COMPARISON BETWEEN TWO FISH TECHNIQUES IN THE IN VITRO STUDY OF CYTOGENETIC MARKERS FOR LOW-DOSE X-RAY EXPOSURE IN HUMAN PRIMARY FIBROBLASTS

Frontiers in Genetics, 2013
This work is about the setup of an in vitro system to report low-dose of X-rays as measured as cytogenetic damage. Q- and m-FISH, for telomere length and chromosome instability analysis respectively, were compared to evaluate their sensitivity in the low-
Dino eNieri, Francesco eBerardinelli, Antonio eAntoccia, Caterina eTanzarella, Antonella eSgura   +4 more
doaj   +1 more source

Sister chromatid exchanges and structural chromosome aberrations in relation to smoking in 91 individuals.

Hereditas, 2008
Sister chromatid exchanges (SCE) and structural chromosome aberrations were analyzed in peripheral blood lymphocytes and correlated to smoking habits of 91 individuals.
K. Hedner, B. Högstedt, A. Kolnig, E. Mark-Vendel, B. Strömbeck, F. Mitelman   +5 more
semanticscholar   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

DNA aberrations in urinary bladder cancer detected by flow cytometry and fish: prognostic implications

European Journal of Histochemistry, 2009
We evaluated the genetic changes in bladder cancer biopsy by fluorescence in situ hybridization (FISH) and related them to stage and grade of the tumor, ploidy (FCM) and clinical outcome, to determine a simple method to identify tumors with a poorer ...
AM Cianciulli, R Bovani, C Leonardo, F Iori, AM Coletta, R Marzano, A Antenucci, GM Gandolfo, C Laurenti   +8 more
doaj   +1 more source

Clonal chromosomal and genomic instability during human multipotent mesenchymal stromal cells long-term culture. [PDF]

PLoS ONE, 2018
Spontaneous mutagenesis often leads to appearance of genetic changes in cells. Although human multipotent mesenchymal stromal cells (hMSC) are considered as genetically stable, there is a risk of genomic and structural chromosome instability and ...
Victoria Nikitina, Tatiana Astrelina, Vladimir Nugis, Aleksandr Ostashkin, Tatiana Karaseva, Ekaterina Dobrovolskaya, Dariya Usupzhanova, Yulia Suchkova, Elena Lomonosova, Sergey Rodin, Vitaliy Brunchukov, Stanislav Lauk-Dubitskiy, Valentin Brumberg, Anastasia Machova, Irina Kobzeva, Andrey Bushmanov, Aleksandr Samoilov   +16 more
doaj   +1 more source

Chromosome aberrations and sister chromatid exchanges in lead‐exposed workers

, 2009
Chromosomal aberrations and sister chromatid exchanges (SCEs) were studied in peripheral blood lymphocytes of 18 workers exposed to lead in a smeltery and 12 unexposed controls.
J. Mäki‐Paakkanen, M. Sorsa, H. Vainio   +2 more
semanticscholar   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Global methylation status of sperm DNA in carriers of chromosome structural aberrations

Asian Journal of Andrology, 2017
Male infertility might be clearly associated with aberrant DNA methylation patterns in human spermatozoa. An association between oxidative stress and the global methylation status of the sperm genome has also been suggested.
Marta Olszewska, Miroslawa Z Barciszewska, Monika Fraczek, Nataliya Huleyuk, Vyacheslav B Chernykh, Danuta Zastavna, Jan Barciszewski, Maciej Kurpisz   +7 more
doaj   +1 more source

The Impact of Cytogenetic Aberrations in the Clonal Evolution of Chronic Myeloid Leukemia: A Single-Center Experience Among 450 Turkish Patients (Cohort Study)

Turkish Journal of Hematology, 2022
Objective: Objective: Chronic myeloid leukemia (CML) is a clonal hematologic disorder characterized by t(9;22) translocation, in which cytogenetic aberrations can occur in Ph(+) and (-) clones. These aberrations develop due to clonal evolution as well as
Sevgi Işık, Gülçin Günden, Hava Üsküdar Teke, Olga Meltem Akay, Nur Oğuz Davutoğlu, Vahap Aslan, Mustafa Karagülle, Hülya Özen, Oğuz Çilingir, Sevilhan Artan, Beyhan Durak Aras   +10 more
doaj   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source