Results 91 to 100 of about 409,247 (302)

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

The prevalence of the 47, XYY chromosome abnormality in selected human populations

, 1972
The purpose of this research was to examine four selected human population groups, institutionalized and normal, to determine the prevalence of the 47, XYY chromosome abnormality among adult males.Thesis (D. Ed.
Exley, Ethelyn Elaine, 1931-
core  

Psychotic disorder and focal epilepsy in a left-handed patient with chromosome XYY abnormality

, 2008
Psychotic disorder and focal epilepsy in a left-handed patient with chromosome XYY abnormality: Objective: To discuss the relationship between XYY chromosome abnormality, psychiatric disorders and epilepsy. Method: Single case report.
Perucca, P, Verri, AP, Cremante, A, Galimberti, CA, Uggetti, A, VERNICE, MIRTA   +5 more
core   +1 more source

The prognostic impact of loss of chromosome 7 material detected by fluorescence in situ hybridization (FISH) in myeloid malignancies

Journal of the Egyptian National Cancer Institute, 2018
Background: Monosomy 7 (−7) or deletion in its long arm [del(7q)] is among the most common chromosomal abnormalities in myeloid malignancies. There are prognostic variations between −7 and del(7q) in acute myeloid leukemia (AML) and myelodysplastic ...
Mohamed Amr M. El-Menoufy, Zeinab I. Mourad, Nahla M. Farahat   +2 more
doaj   +1 more source

Charting Morphotoxicity With Complementary Embryo Models

Advanced Healthcare Materials, EarlyView.
Three human embryo models of the peri‐implantation stages are exposed to a library of compounds. The (toxic) effects of the compounds are analyzed through automated image analysis pipelines. By evaluating the differential responses of the embryo models, this study underscores the importance of testing complementary embryo models to achieve robust and ...
Dorian G. Luijkx, Pauline L. Balder, Romy M. L. Verhagen, Vinidhra Shankar, Barry Jutten, Pinak Samal, Timo Rademakers, Clemens A. van Blitterswijk, Stefan Giselbrecht, Erik J. Vrij   +9 more
wiley   +1 more source

Chromosome Structural Alteration an Unusual Abnormality Characterizing Human Neoplasia

Novelty in Biomedicine, 2016
Background and Aim: Ring chromosomes are rare cytogenetic abnormalities that occur in less than 10% of hematopoietic malignancies. They are rare in blood disorder.
Abolfazl Movafagh, Mehrdad Hashemi, Atefeh Heidary Pour, Davood Zare-Abdollahi, Babak Emamalizadeh, Farhad Shahvaisizadeh, Neda Mansouri, Mohammad Hassan Heidari, Hassan Tonekaboni   +8 more
doaj  

Cytogenetic Findings in Mentally Retarded Iranian Patients

Balkan Journal of Medical Genetics, 2012
We conducted a cytogenetic study on 865 individuals with idiopathic mental retardation (MR) who were admitted to the Cytogenetics Department of the Iran Blood Transfusion Organisation (IBTO) Research Centre, Tehran, Iran; these were performed on blood ...
Nasiri F., Mahjoubi F., Manouchehry F., Razazian F., Mortezapour F., Rahnama M.   +5 more
doaj   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Chromosome segregation and recombination in human meiosis: Clinical applications and insight into disjunction errors [PDF]

, 2015
Chromosome copy number errors (or aneuploidy) of gametes and embryos occurs in humans more frequently than in any other studied species, with a spectrum of manifestations from implantation failure to affected live births.
Ottolini, Christian Simon, The Bridge Centre Ltd, UK   +1 more
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The MatP/matS Site-Specific System Organizes the Terminus Region of the E. coli Chromosome into a Macrodomain [PDF]

, 2008
The organization of the Escherichia coli chromosome into insulated macrodomains influences the segregation of sister chromatids and the mobility of chromosomal DNA.
El Karoui, Meriem, Schbath, Sophie, Petit, Marie-Agnès, Mercier, Romain, Robin, Stéphane, Espéli, Olivier, Boccard, Frédéric, Petit, Marie Agnès   +7 more
core   +1 more source