Results 121 to 130 of about 27,794 (295)

Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu   +6 more
wiley   +1 more source

C-banding in maize II. Identification of somatic chromosomes [PDF]

open access: bronze, 1985
Margarida Lopes Rodrigues de Aguiar-Perecin   +1 more
openalex   +1 more source

Cancer: From a Genetic Disorder to a Systemic Disease

open access: yes
Advanced Science, EarlyView.
Ada Hang‐Heng Wong, Yuming Hu
wiley   +1 more source

TARDBP (TDP‐43) Knock‐in Zebrafish Display a Late‐Onset Motor Phenotype and Loss of Large Spinal Cord Motor Neurons

open access: yesAnnals of Neurology, EarlyView.
Objective Mutations in TARDBP (encoding TDP‐43) are associated with the neurodegenerative disease amyotrophic lateral sclerosis (ALS) and include familial missense mutations where there are a lack of models and mechanisms examining how they are pathogenic.
Ziyaan A. Harji   +10 more
wiley   +1 more source

Endogenously Triggered DNAzyme‐Based Nanostructures for Gene‐Combined Therapy

open access: yesAdvanced NanoBiomed Research, EarlyView.
DNAzymes show great promise for gene regulation and therapeutic use via controlled release triggered by endogenous factors. This review summarizes recent advances in designing and constructing nanoscale platforms enabling endogenously triggered release of DNAzyme.
Theoneste Muyizere   +4 more
wiley   +1 more source

From WGS to gels: Development and testing of PCR primers targeting toxic Digitalis in support of food safety

open access: yesApplications in Plant Sciences, EarlyView.
Abstract Premise This study capitalized on a library of single‐nucleotide polymorphisms created via whole genome sequencing (WGS) to develop and test a PCR assay for detecting toxic Digitalis species in food products. Complex foods can be difficult to analyze, but safeguarding consumer well‐being and public health necessitates that products regulated ...
Elizabeth Sage Hunter   +5 more
wiley   +1 more source

Evolutionary trends in the family Curimatidae (Characiformes): inferences from chromosome banding. [PDF]

open access: yesComp Cytogenet, 2016
Sampaio TR   +5 more
europepmc   +1 more source

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