Results 91 to 100 of about 3,192,378 (312)

Unique and conserved MicroRNAs in wheat chromosome 5D revealed by next-generation sequencing [PDF]

, 2013
MicroRNAs are a class of short, non-coding, single-stranded RNAs that act as post-transcriptional regulators in gene expression. miRNA analysis of Triticum aestivum chromosome 5D was performed on 454 GS FLX Titanium sequences of flow sorted chromosome 5D
Hikmet Budak (150694), Melda Kantar, Kurtoglu Kuaybe Yucebilgili, Lucas, Stuart J., Stuart J. Lucas (150688), Stuart J Lucas, Budak, Hikmet, Yucebilgili, Kuaybe, Melda Kantar (402943), Kuaybe Yucebilgili Kurtoglu (436352), Lucas Stuart J., Kantar Melda, Hikmet Budak, Budak Hikmet, Kantar, Melda, Kuaybe Yucebilgili Kurtoglu   +15 more
core   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Prokaryotic ParA–ParB–parS system links bacterial chromosome segregation with the cell cycle [PDF]

, 2012
While the essential role of episomal par loci in plasmid DNA partitioning has long been appreciated, the function of chromosomally encoded par loci is less clear. The chromosomal parA–parB genes are conserved throughout the bacterial kingdom and encode
Mierzejewska, Jolanta, Jolanta Mierzejewska, Grażyna Jagura-Burdzy, Jagura-Burdzy, Grazyna   +3 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Array CGH based identification of amplified chromosome 8p11.23-11.22 region encompassing ADAM9 gene.

, 2013
Array CGH based identification of amplified chromosome 8p11.23-11.22 region encompassing ADAM9 gene.
Rosnah Binti Zain (279750), Vui King Vincent-Chong (279735), Padmaja Jayaprasad Pradeep (279738), Mannil Thomas Abraham (279748), Siti Mazlipah Ismail (279740), Anand Ramanathan (279744), Nur Aaina Binti Mohd Mohayadi (279745), Arif Anwar (248937), Sok Ching Cheong (279737), Nurul Shielawati Binti Mohamed Rosli (279746), Zuraiza Mohamad Zaini (279741), Narayanan Prepageran (279742), Lee Peng Karen-Ng (279736), Wan Mahadzir Wan Mustafa (279747), Yi-Hsin Yang (150372), Zainal Ariff Abdul Rahman (279739), Thomas George Kallarakkal (279743), Keng Kiong Tay (279749)   +17 more
core   +1 more source

A family case of fertile human 45,X,psu dic(15;Y) males [PDF]

, 2006
We report on a familial case including four male probands from three generations with a 45,X,psu dic(15;Y)(p11.2;q12) karyotype. 45,X is usually associated with a female phenotype and only rarely with maleness, due to translocation of small Y chromosomal
P.M. Gopinath, Hansmann, Ingo, I. Hansmann, Schempp, Werner, Wimmer, R., Palaniappan, I., Wimmer, Rainer, W. Schempp, I. Palaniappan, Palaniappan, Ilayaraja, Gopinath, P. M., N. Chandra, Hansmann, I., Chandra, N., Nagarajappa, C. S., R. Wimmer, C.S. Nagarajappa, Schempp, W.   +17 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Advances in the Application of Plant Chromosome Rearrangement in Crop Genetic Improvement

Guangdong nongye kexue
Chromosome rearrangement is a mechanism that can lead to the loss, duplication, translocation and inversion of DNA segments, thereby altering the genomic structure and providing possibilities for creating new variable traits.
Jiao XUE, Qingfeng ZHU, Pei CHEN, Yanzhao FENG, Yang YU   +4 more
doaj   +1 more source

Bidirectional transcription of a novel chimeric gene mapping to mouse chromosome Yq. [PDF]

, 2007
Background The male-specific region of the mouse Y chromosome long arm (MSYq) contains three known highly multi-copy X-Y homologous gene families, Ssty1/2, Sly and Asty.
Nabeel A Affara, Ellis, Peter J.I., Clemente, Emily J., Peter JI Ellis, Emily J Clemente, Ferguson, Lydia, Affara, Nabeel A., Lydia Ferguson   +7 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source