Results 191 to 200 of about 194,576 (309)

NDRG1‐Driven Lactate Accumulation Promotes Lung Adenocarcinoma Progression Through the Induction of an Immunosuppressive Microenvironment

Advanced Science, EarlyView.
NDRG1 drives lactate accumulation and histone lactylation in lung adenocarcinoma, promoting immunosuppression via M2 macrophage polarization and CD8⁺ T cell inhibition. High NDRG1 expression correlates with poor prognosis, an immunosuppressive microenvironment, and immunotherapy resistance.
Gujie Wu, Hongxia Cheng, Jiacheng Yin, Yuansheng Zheng, Haochun Shi, Binyang Pan, Ming Li, Mengnan Zhao, Jiaqi Liang, Yunyi Bian, Guangyao Shan, Guoshu Bi, Weigang Guo, Lin Wang, Yiwei Huang   +14 more
wiley   +1 more source

A Comprehensive Review: Genetic Mapping of Genes Associated with Green Leaf Color Variations in Main Vegetable Crops. [PDF]

Plants (Basel)
Wang M, Wang X, Wang Y, Yang X, Li X, Chen J, Feng S.   +6 more
europepmc   +1 more source

Isolation and mapping of a polymorphic DNA sequence (pEFD49.2) on chromosome 15 [Dl5S38]

, 1988
E. Fujimoto, Yusuke Nakamura, L. Ballard, P. OʼConnell, M. Leppert, G.M. Lathrop, Jean-Marc Lalouel, R. White   +7 more
openalex   +2 more sources

Neural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21. [PDF]

, 1993
Avi Orr‐Urtreger, Luba Trakhtenbrot, R Ben-Levy, D Wen, Gideon Rechavi, Peter Lonai, Y Yarden   +6 more
openalex   +1 more source

A Super‐Enhancer‐Driven Transcriptional Regulatory Circuit Underlying Abiraterone Resistance in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
This study identifies a super‐enhancer‐driven transcriptional regulatory circuit comprising BCL6, SMAD3, and NFIB that cooperate to drive cholesterol synthesis via SREBF2/HMGCR/FDFT1 activation and regulate CDK2/CCND3 for cell cycle control. Targeting this circuit with BI‐3802 or downstream inhibitors (Fatostatin/Lovastatin) overcomes abiraterone ...
Liling Jiang, Jiamin Wang, Guanjie Peng, Haichuan Zhang, Jinxin Fang, Yingyin Gao, Enzhe Lou, Yangzhou Liu, Wa Ding, Bingyuan Liu, Qiong Mao, Lizhen Jiang, Aochu Liu, Xinyue Li, Shiwen Hu, Qiaomin Ma, Yueyuan Zheng, Zhigang Zhao, Xianping Shi   +18 more
wiley   +1 more source

Heat waves reveal additive genetic effects leading to sunburn resilience of grapevine berries. [PDF]

Front Plant Sci
Heinekamp T, Röckel F, Herzog K, Trapp O, Töpfer R, Schwander F.   +5 more
europepmc   +1 more source

Anti‐Inflammatory Mechanisms of Selenium Nanosheets in Ulcerative Colitis: Protein Corona, GP130 Interaction, and Transcriptomic Profile

Advanced Science, EarlyView.
SeNSs provide a biocompatible, anti‐inflammatory UC therapy. SeNSs form protein coronas enriched with AKT/PI3K/NF‐κB pathway proteins, suppress GP130 via hydrophobic interactions, and inhibit pro‐inflammatory cytokines. In DSS‐induced UC mice, SeNSs reduce inflammation, tissue damage, and disease activity by modulating cytokine, chemokine, and ...
Dingyi Shen, Li Gong, Wei Yang, Jiaqi Luo, Zhen Jin, Youzhi Tang   +5 more
wiley   +1 more source

Whole genome sequences of 297 Duolang sheep for litter size. [PDF]

Sci Data
Fang C, Druet T, Cao H, Liu W, Chen Q, Farnir F.   +5 more
europepmc   +1 more source

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

Advanced Science, EarlyView.
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao, Jiawei Zhou, Chen‐Chen Wang, Zong‐Hao Wang, Nian‐Dong Mao, Meng‐Lan He, Peng‐Peng Zhang, Ping Huang, Guo‐Wei Ye, Yu‐Qing Zhang, Feng‐Hui Tang, Hang Zhang, Tian Xie, Xiang‐Yang Ye   +13 more
wiley   +1 more source

Genetic mapping of loci associated with yield and their components in black common bean (Phaseolus vulgaris L.). [PDF]

Plant Genome
Reche DL, Gonçalves-Vidigal MC, Vidigal Filho PS, Vaz Bisneta M, Lacanallo GF, Santos AABD, Santos APD.   +6 more
europepmc   +1 more source