Results 241 to 250 of about 2,043,269 (377)

Enhancer Extrachromosomal Circular DNA ANKRD28 Elicits Drug Resistance via POU2F2‐Mediated Transcriptional Network in Multiple Myeloma

Advanced Science, EarlyView.
Enhancer eccANKRD28‐manipulated MM cells have been demonstrated to facilitate drug resistance and promote MM progression by activating the key transcription factor, POU2F2. POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes (IRF4, JUNB, IKZF3, et al.
Binzhen Chen, Jia Liu, Yaoxin Zhang, Changming Shi, Di Zhu, Guoqiang Zhang, Fei Xiao, Lu Zhong, Minyue Zhang, Lai Guan Ng, Honghui Huang, Tingting Lu, Jian Hou   +12 more
wiley   +1 more source

Integrative QTL mapping and candidate gene analysis for main stem node number in soybean. [PDF]

BMC Plant Biol
Zha B, Zhang C, Yuan R, Zhao K, Sun J, Liu X, Wang X, Zhang F, Zhang B, Lamlom SF, Ren H, Qiu L.   +11 more
europepmc   +1 more source

Single‐Cell Analysis Clarifies Pathological Heterogeneity in Tenosynovial Giant Cell Tumor and Identifies Biomarkers for Predicting Disease Recurrence

Advanced Science, EarlyView.
MP3 tumor cells, a specific subpopulation of tumor cells in D‐TGCT, regulated the differentiation of CD34+ Fbs into MMP3+ Fbs and APOE+ Fbs through COL6A3 − (ITGAV + ITGB8) interaction. APOE+ Fbs activated IL‐1B+CCL20+ Mφs through the CXCL12/CXCR4 axis. IL‐1B+CCL20+ Mφs and MMP3+ Fbs participated in the local invasion of D‐TGCT.
Yubin Xie, Chen Chen, Fei Wu, Yiman Peng, Jing Su, Yang Zhao, Hongjie Huang, Zhong Alan Li, Yin Pei, Wencui Li, Yi He, Tianchen Xue, Chenxi Cao, Sui Peng, Xin Zhang, Weidong Song   +15 more
wiley   +1 more source

Genetic dissection of QTL for important agronomic traits and fine-mapping of qGL4 and qGW6 based on a short-width grain rice CSSL-Z691. [PDF]

Front Plant Sci
Yu Z, Xu G, Xie K, Xie Z, Wang D, Tan L, Ling Y, He G, Zhao F.   +8 more
europepmc   +1 more source

The Hypoxia‐Associated High‐Risk Cell Subpopulation Distinctly Enhances the Progression of Glioma

Advanced Science, EarlyView.
This study suggests the potential roles of a novel hypoxia‐associated CDC20+KIF20A+PTTG1+ cell subpopulation in glioma progression. This high‐risk glioma cell subpopulation is therapeutically vulnerable to glioma progression and may play important roles in glioma standard‐of‐care therapeutic resistance.
Quan Wan, Xuechao Wu, Jinxu Zhou, Weiqi Wu, Yuanliang Cao, Cuiping Sun, Zheng Li, Zhicheng Gong, Hong Tang, Qilin Li, Junsheng Chu, Qing Wang, Kaisa Cui, Xiaojie Lu   +13 more
wiley   +1 more source

Reference-free identification and pangenome analysis of accessory chromosomes in a major fungal plant pathogen. [PDF]

NAR Genom Bioinform
van Westerhoven AC, Fokkens L, Wissink K, Kema GHJ, Rep M, Seidl MF.   +5 more
europepmc   +1 more source

Isolation and mapping of a polymorphic DNA sequence (pMCT32.1) on chromosome 3 [D3S31]

, 1988
M. Carlson, Yusuke Nakamura, K. Krapcho, P. O’Connell, M. Leppert, G.M. Lathrop, J.-M. Lalouel, R. White   +7 more
openalex   +2 more sources

Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure‐Based Virtual Screening

Advanced Science, EarlyView.
Pancreatic cancer is a highly aggressive malignancy with limited treatment options. CLK4 regulates alternative splicing, contributing to cancer progression. This study establishes a computational model to identify CLK4 inhibitors, leading to compound 150441 (IC50: 21.4 nm).
Chun‐Lin Yang, Yi‐Wen Wu, Huang‐Ju Tu, Yun‐Hsuan Yeh, Tony Eight Lin, Tzu‐Ying Sung, Mu‐Chun Li, Shih‐Chung Yen, Jui‐Hua Hsieh, Ming‐Chin Yu, Sen‐Yung Hsieh, Hsing‐Pang Hsieh, Shiow‐Lin Pan, Kai‐Cheng Hsu   +13 more
wiley   +1 more source

Unveiling Multi‐Scale Architectural Features in Single‐Cell Hi‐C Data Using scCAFE

Advanced Science, EarlyView.
scCAFE is a deep learning framework designed to identify multi‐scale 3D genome architectural features from single‐cell Hi‐C data without dense imputation. It predicts chromatin loops, TAD‐like domains, and A/B compartments, enabling efficient characterization of organization at the single‐cell level. scCAFE also identifies marker loop anchors, offering
Fuzhou Wang, Jiecong Lin, Hamid Alinejad‐Rokny, Wenjing Ma, Lingkuan Meng, Lei Huang, Jixiang Yu, Nanjun Chen, Yuchen Wang, Zhongyu Yao, Weidun Xie, Ka‐Chun Wong, Xiangtao Li   +12 more
wiley   +1 more source

Mapping Genomic Regions for Grain Protein Content and Quality Traits in Milled Rice (<i>Oryza sativa</i> L.). [PDF]

Plants (Basel)
Bharali V, Yadla S, Thati S, Bitra B, Karapati D, Chirravuri NN, Badri J, Sundaram RM, Jukanti AK.   +8 more
europepmc   +1 more source