Results 261 to 270 of about 237,732 (314)

Linkage maps of human chromosomes

Genome, 1989
Finding the chromosomal location of human genes that heretofore have been defined solely by phenotypes, in particular clinical phenotypes that are transmitted in Mendelian fashion in families, is an early and often crucial step in the process of identifying the molecular basis of a disease.
R, White, J M, Lalouel, M, Leppert, M, Lathrop, Y, Nakamura, P, O'Connell   +5 more
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A revised map of chromosome 1

Annals of Human Genetics, 1984
SummaryThe genetic map of chromosome 1 reported by Keats, Morton & Rao (1981) has been updated using recent recombination data and regional assignments from the Galton Laboratory (King, 1982a) and from the current literature. A maximum likelihood mapping technique using pairwise recombination data without a chiasma map was developed, based on the ...
S L, Sherman, J, King, E B, Robson, S, Yee   +3 more
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Chromosome Mapping with DNA Markers

Scientific American, 1988
New markers called RFLP's (for restriction-fragment length polymorphisms) can indicate the location on a chromosome of a disease-causing gene and serve to identify carriers. With enough markers one can map the human chromosomes--the first step toward an ambitious goal of molecular biology: sequencing the entire human genome.
R, White, J M, Lalouel
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Standard maps of chromosome 10

Annals of Human Genetics, 1990
SUMMARYTo achieve consensus more exact definitions of genetical maps are required, of which standard, comprehensive and skeletal might be some. A standard genetic map gives distance from pter in centimorgans (cM), uses the international nomenclature for assigned loci, is sex‐specific, and allows as well as possible for interference and typing errors. A
Morton, Newton, Collins, Andrew
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Chromosome maps of man and mouse

Clinical Genetics, 1981
Graphical displays and listings are presented showing the chromosomal locations of the loci referred to in the Edinburgh Human Gene Mapping Conference (1979), those regarded as homologous between mouse and man, and some others used in linkage studies of chromosomal rearrangements in the mouse.
T P, Dalton, J H, Edwards, E P, Evans, M F, Lyon, S P, Parkinson, J, Peters, A G, Searle   +6 more
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Molecular mapping of rice chromosomes

Theoretical and Applied Genetics, 1988
We report the construction of an RFLP genetic map of rice (Oryza sativa) chromosomes. The map is comprised of 135 loci corresponding to clones selected from a PstI genomic library. This molecular map covers 1,389 cM of the rice genome and exceeds the current classical maps by more than 20%. The map was generated from F2 segregation data (50 individuals)
S R, McCouch, G, Kochert, Z H, Yu, Z Y, Wang, G S, Khush, W R, Coffman, S D, Tanksley   +6 more
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Genetic mapping: X chromosome

Human Genetics, 1983
Starting with the male chiasma distribution for chromosome 2, a significantly better fit is obtained to lod scores for the X chromosome if terminalization of distal chiasmata is assumed. The linkage data are not consistent with a uniform distribution of chiasmata, absence of terminalization, or restriction of terminalization to the distal band.
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Integrating maps of chromosome 16

Current Opinion in Genetics & Development, 1993
The recently published, detailed cytogenetic-based physical map of chromosome 16 has the highest resolution of any autosomal cytogenetic map thus far constructed. The genetic map has been integrated with the cytogenetic map to facilitate the regional localization of disease genes by linkage.
J C, Mulley, G R, Sutherland
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Integrating maps of chromosome 21

Current Opinion in Genetics & Development, 1992
The past year has seen major progress in the construction of various types of maps of human chromosome 21. Perhaps more significantly, the chromosome 21 research community is making very significant progress on integration of these maps through the use of common resources and increased collaboration and communication.
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Physical Mapping of Human Chromosomes

1992
A major focus of modern molecular biology is the isolation and analysis of genes based upon associated phenotypes. The strategies for “positional cloning,” where a gene is cloned, analyzed and the basic underlying biology uncovered based upon its chromosomal map location alone, form the basis of much modern molecular genetics research and has made ...
G A, Evans, D L, McElligott
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