Results 251 to 260 of about 414,431 (313)

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

Advanced Science, EarlyView.
Tumor evolution in lung adenocarcinoma is shaped by genetic alterations and spatial immune dynamics. By integrating whole‐exome sequencing, imaging mass cytometry, and spatial transcriptomics across two mouse models, this study reveals how mutational burden, immune infiltration, and cell–state interactions evolve during early and late carcinogenesis ...
Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian‐Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao‐Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y. Liu, Beibei Huang, Frank R. Rojas, Parra Cuentas. Edwin Roger, Ou Shi, Monique B. Nilsson, Alissa Poteete, Khaja B. Khan, Wei Lu, Luisa M. Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I. Wistuba, Zhubo Wei, Linghua Wang, Don L. Gibbons, Ken Chen, Alexandre Reuben, Jason M. Schenke, John V. Heymach, Chao Cheng, Jia Wu, Jianjun Zhang   +34 more
wiley   +1 more source

Identification of new QTLs for quality traits and yield using tetraploid wheat interspecific backcross inbred lines. [PDF]

BMC Genomics
Marcotuli I, Soriano JM, Colasuonno P, Muciaccia S, Gadaleta A.   +4 more
europepmc   +1 more source

CLinNET: An Interpretable and Uncertainty‐Aware Deep Learning Framework for Multi‐Modal Clinical Genomics

Advanced Science, EarlyView.
Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi, Mohammad Mahdi Hosseini, Ahmadreza Argha, Roxana Zahedi, Nigel H. Lovell, Hamid Alinejad‐Rokny   +5 more
wiley   +1 more source

Whole genome sequences of 289 native cattle from Finland, the Netherlands, and Portugal. [PDF]

Sci Data
Ginja C, Gao J, Kantanen J, Ghanem N, Kugonza D, Makgahlela M, Pires AE, Usié A, Dibbits B, de Sousa CB, Gaspar D, Ruvinskiy D, Bijl E, Smidt H, Lindeberg H, Bovenhuis H, Laport K, Pokharel K, Blaschikoff L, Weldenegodguad M, Prendes RG, Okwasiimire R, Guimarães S, Lui Y, Crooijmans RPMA.   +24 more
europepmc   +1 more source

High‐resolution mapping of the pericentromeric region on wheat chromosome arm 5AS harbouring the Fusarium head blight resistance QTLQfhs.ifa‐5A

, 2017
Maria Buerstmayr, Barbara Steiner, Christian Wagner, Petra Schwarz, Klaus Brugger, Delfina Barabaschi, Andrea Volante, Giampiero Valè, Luigi Cattivelli, Hermann Buerstmayr   +9 more
openalex   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Comparative Chromosomal Mapping of the 18S rDNA Loci in True Bugs: The First Data for 13 Genera of the Infraorders Cimicomorpha and Pentatomomorpha (Hemiptera, Heteroptera). [PDF]

Genes (Basel)
Golub NV, Anokhin BA, Grozeva S, Kuznetsova VG.   +3 more
europepmc   +1 more source

cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria.

, 1994
Hiroki Yokota, Pedro M. Fernández‐Salguero, H. Furuya, Lin Ke-rong, O. Wesley McBride, Beate Podschun, Klaus D. Schnackerz, Frank J. Gonzalez   +7 more
openalex   +1 more source

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source