Results 261 to 270 of about 194,576 (309)
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Chromosome Mapping with DNA Markers
Scientific American, 1988New markers called RFLP's (for restriction-fragment length polymorphisms) can indicate the location on a chromosome of a disease-causing gene and serve to identify carriers. With enough markers one can map the human chromosomes--the first step toward an ambitious goal of molecular biology: sequencing the entire human genome.
Raymond E. White, Jean-Marc Lalouel
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Integrating maps of chromosome 21
Current Opinion in Genetics & Development, 1992The past year has seen major progress in the construction of various types of maps of human chromosome 21. Perhaps more significantly, the chromosome 21 research community is making very significant progress on integration of these maps through the use of common resources and increased collaboration and communication.
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2001
A central problem in cytogenetics is mapping the location of each gene. This involves determining their linear order and the physical distance and frequency of meiotic recombination between all components of each chromosome, especially the genes. The rate of progress in mapping the human chromosomes has increased rapidly.
Eeva Therman, Orlando J. Miller
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A central problem in cytogenetics is mapping the location of each gene. This involves determining their linear order and the physical distance and frequency of meiotic recombination between all components of each chromosome, especially the genes. The rate of progress in mapping the human chromosomes has increased rapidly.
Eeva Therman, Orlando J. Miller
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Molecular mapping of rice chromosomes
Theoretical and Applied Genetics, 1988We report the construction of an RFLP genetic map of rice (Oryza sativa) chromosomes. The map is comprised of 135 loci corresponding to clones selected from a PstI genomic library. This molecular map covers 1,389 cM of the rice genome and exceeds the current classical maps by more than 20%. The map was generated from F2 segregation data (50 individuals)
Steven D. Tanksley +6 more
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Development, 1987
DNA probes isolated from the human Y chromosome have been used to resolve two fundamental problems concerning the biology of sex determination in man. Coincidentally, resolution of these problems has generated genetic maps of the short arm of the human Y chromosome and has allowed the regional localization of TDF .
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DNA probes isolated from the human Y chromosome have been used to resolve two fundamental problems concerning the biology of sex determination in man. Coincidentally, resolution of these problems has generated genetic maps of the short arm of the human Y chromosome and has allowed the regional localization of TDF .
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Chromosome maps of man and mouse
Clinical Genetics, 1981Graphical displays and listings are presented showing the chromosomal locations of the loci referred to in the Edinburgh Human Gene Mapping Conference (1979), those regarded as homologous between mouse and man, and some others used in linkage studies of chromosomal rearrangements in the mouse.
Mary F. Lyon +6 more
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New England Journal of Medicine, 1987
Of all life's inequalities, the contrast between the X and Y chromosomes is one of the most fundamental and certainly one of the most intriguing.
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Of all life's inequalities, the contrast between the X and Y chromosomes is one of the most fundamental and certainly one of the most intriguing.
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Mapping of Polytene Chromosomes
2000Principle and Polytene chromosomes consist of up to several thousands of chromatids applications and are therefore especially suitable for direct mapping with the help ofIn situhybridization. With the introduction of nonradioactive labeling and detection methods, e.g., fluorescenceIn situhybridization (FISH) (Lan-ger-Safer et al., 1982), theIn ...
Erwin R. Schmidt, Christiane Kraemer
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Physical Mapping of Human Chromosomes
1992A major focus of modern molecular biology is the isolation and analysis of genes based upon associated phenotypes. The strategies for “positional cloning,” where a gene is cloned, analyzed and the basic underlying biology uncovered based upon its chromosomal map location alone, form the basis of much modern molecular genetics research and has made ...
David L. McElligott, Glen A. Evans
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Integrating maps of chromosome 16
Current Opinion in Genetics & Development, 1993The recently published, detailed cytogenetic-based physical map of chromosome 16 has the highest resolution of any autosomal cytogenetic map thus far constructed. The genetic map has been integrated with the cytogenetic map to facilitate the regional localization of disease genes by linkage.
Grant R. Sutherland, John C. Mulley
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