Results 321 to 330 of about 2,231,714 (417)

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

Advanced Science, EarlyView.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li, Ying Zhang, Zhenyu Xiao, Jieyu Qi   +3 more
wiley   +1 more source

Genome assemblies of Nuttall's White-crowned sparrow (Zonotrichia leucophrys nuttalli) and Rufous-collared sparrow (Zonotrichia capensis). [PDF]

Sci Data
Wu Z, Miedzinska K, Krause JS, Gonzalez-Gomez PL, Pérez JH, Wingfield JC, Meddle SL, Smith J.   +7 more
europepmc   +1 more source

CircDNA2‐Educated YTHDF2 Phase Separation Promotes PM2.5‐Induced Malignant Transformation Through the Blunting of GADD45A Expression

Advanced Science, Volume 12, Issue 14, April 10, 2025.
This study unveiled the mechanism by which circDNA2‐educated YTHDF2 phase separation promotes PM2.5‐induced malignant transformation in HBE cells by blunting GADD45A expression, providing definitive evidence for the first time that LLPS is involved in the induction of tumorigenesis by particulate pollutants. Moreover, the clinical value of circDNA2 and
Jie Xu, Zhi Ling, Lijia Yin, Duo Xu, Shenshen Wu, Rui Chen   +5 more
wiley   +1 more source

Corrigendum: Saturation mapping of a major effect QTL for stripe rust resistance on wheat chromosome 2B in cultivar Napo 63 using SNP genotyping arrays. [PDF]

Front Plant Sci
Wu J, Wang Q, Liu S, Huang S, Mu J, Zeng Q, Huang L, Han D, Kang Z.   +8 more
europepmc   +1 more source

X‐Linked Gene Dosage and SOX2 Act as Key Roadblocks for Human Germ Cell Specification in Klinefelter Syndrome

Advanced Science, Volume 12, Issue 15, April 17, 2025.
Klinefelter syndrome‐derived iPSCs provide an excellent model for studying X chromosome inactivation and functions of escapee genes during human primordial germ cell‐like cells differentiation process. Downregulation of three X‐linked genes—IGSF1, CHRDL1, and USP9X—significantly enhances the efficiency of hPGCLCs.
Wenteng He, Qing Luo, Jian Zhao, Mengting Wang, Allan Zhao, Luohua Feng, Ahmed Reda, Eva Lindgren, Jan‐Bernd Stukenborg, Jiayu Chen, Qiaolin Deng   +10 more
wiley   +1 more source

Molecular mapping of a novel locus S68 for intrasubspecific hybrid sterility in indica-indica hybrid. [PDF]

Sci Rep
Song X, Yang Y, Pu Q, Zhou J, Lv Y, Jiang X, Li J, Deng X, Tao D, Zhang Y.   +9 more
europepmc   +1 more source

Injectable pH Responsive Conductive Hydrogel for Intelligent Delivery of Metformin and Exosomes to Enhance Cardiac Repair after Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Injectable pH responsive conductive hydrogel for intelligent delivery of metformin and exosomes to alleviate myocardial ischemia‐reperfusion injury. The hydrogel responds to the weakly acidic microenvironment of ischemic injury and can significantly reduce the production of intracellular ROS and enhance cardiac conduction, thereby resisting apoptosis ...
Nianlan Cheng, Qiao Luo, Yongqing Yang, Ni Shao, Tianqi Nie, Xiujiao Deng, Jifeng Chen, Siqi Zhang, Yanyu Huang, Kuan Hu, Liangping Luo, Zeyu Xiao   +11 more
wiley   +1 more source

Chromosomal-level genome assembly of Trichogramma dendrolimi (Trichogrammatidae: Hymenoptera). [PDF]

Sci Data
Dong Q, Dong Z, Ning S, Li G, Che W, Fang G, Zhan S, Zhou J, Dong H.   +8 more
europepmc   +1 more source

HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Hepatocyte Nuclear Factor 3 alpha (HNF3α) is significantly upregulated in renal tubular epithelial cells of CKD patients and fibrotic mice. Deletion of HNF3α mitigates IRI‐induced renal fibrosis, while overexpression worsens it. HNF3α directly regulates NCK‐associated protein 1‐like (Nckap1l), whose overexpression exacerbates fibrosis.
Ling Hou, Yan Guo, Shuang Xu, Mi Bai, Weidong Cao, Yue Zhang, Zhanjun Jia, Aihua Zhang   +7 more
wiley   +1 more source

A deficient CP24 allele defines variation for dynamic nonphotochemical quenching and photosystem II efficiency in maize. [PDF]

Plant Cell
Ferguson JN, Caproni L, Walter J, Shaw K, Arce-Cubas L, Baines A, Thein MS, Mager S, Taylor G, Cackett L, Mathan J, Vath RL, Martin L, Genty B, Pè ME, Lawson T, Dell'Acqua M, Kromdijk J.   +17 more
europepmc   +1 more source