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Mapping of Polytene Chromosomes
2000Principle and Polytene chromosomes consist of up to several thousands of chromatids applications and are therefore especially suitable for direct mapping with the help ofIn situhybridization. With the introduction of nonradioactive labeling and detection methods, e.g., fluorescenceIn situhybridization (FISH) (Lan-ger-Safer et al., 1982), theIn ...
Erwin R. Schmidt, Christiane Kraemer
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Integrating maps of chromosome 16
Current Opinion in Genetics & Development, 1993The recently published, detailed cytogenetic-based physical map of chromosome 16 has the highest resolution of any autosomal cytogenetic map thus far constructed. The genetic map has been integrated with the cytogenetic map to facilitate the regional localization of disease genes by linkage.
Grant R. Sutherland, John C. Mulley
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Physical Mapping of Human Chromosomes
1992A major focus of modern molecular biology is the isolation and analysis of genes based upon associated phenotypes. The strategies for “positional cloning,” where a gene is cloned, analyzed and the basic underlying biology uncovered based upon its chromosomal map location alone, form the basis of much modern molecular genetics research and has made ...
David L. McElligott, Glen A. Evans
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Standard maps of chromosome 10
Annals of Human Genetics, 1990SUMMARYTo achieve consensus more exact definitions of genetical maps are required, of which standard, comprehensive and skeletal might be some. A standard genetic map gives distance from pter in centimorgans (cM), uses the international nomenclature for assigned loci, is sex‐specific, and allows as well as possible for interference and typing errors. A
Morton, Newton, Collins, Andrew
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Linkage maps of human chromosomes
Genome, 1989Finding the chromosomal location of human genes that heretofore have been defined solely by phenotypes, in particular clinical phenotypes that are transmitted in Mendelian fashion in families, is an early and often crucial step in the process of identifying the molecular basis of a disease.
Peter O'Connell +5 more
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Annals of Human Genetics, 1984
SummaryThe genetic map of chromosome 1 reported by Keats, Morton & Rao (1981) has been updated using recent recombination data and regional assignments from the Galton Laboratory (King, 1982a) and from the current literature. A maximum likelihood mapping technique using pairwise recombination data without a chiasma map was developed, based on the ...
Stephanie L. Sherman +3 more
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SummaryThe genetic map of chromosome 1 reported by Keats, Morton & Rao (1981) has been updated using recent recombination data and regional assignments from the Galton Laboratory (King, 1982a) and from the current literature. A maximum likelihood mapping technique using pairwise recombination data without a chiasma map was developed, based on the ...
Stephanie L. Sherman +3 more
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1991
In order to map the human genome, the gene, as indicated by expressed gene products, abnormal phenotypes, or markers representing it, must first be assigned to a particular chromosome (from Greek, khroma, colour, and soma, body). For some genes, analysis of pedigree data alone may confirm their localisation.
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In order to map the human genome, the gene, as indicated by expressed gene products, abnormal phenotypes, or markers representing it, must first be assigned to a particular chromosome (from Greek, khroma, colour, and soma, body). For some genes, analysis of pedigree data alone may confirm their localisation.
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Advances in Y chromosome mapping
Current Opinion in Obstetrics and Gynaecology, 1999The human Y chromosome has long been recognized as being responsible for sex determination. In fact, it also encodes more than 30 genes and gene families that participate in a variety of cellular functions, including bone development, tooth growth, and spermatogenesis.
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A mapping function for human chromosomes
Annals of Human Genetics, 1976The available simple mapping functions are surveyed, and a new mapping function that provides for positive interference within chromosome arms and no interference across the centromere is proposed, together with the corresponding formula for centromeric linkage.
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Methods for mapping 3D chromosome architecture
Nature reviews genetics, 2019Rieke Kempfer, A. Pombo
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