Results 231 to 240 of about 626,038 (293)

A Super‐Enhancer‐Driven Transcriptional Regulatory Circuit Underlying Abiraterone Resistance in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
This study identifies a super‐enhancer‐driven transcriptional regulatory circuit comprising BCL6, SMAD3, and NFIB that cooperate to drive cholesterol synthesis via SREBF2/HMGCR/FDFT1 activation and regulate CDK2/CCND3 for cell cycle control. Targeting this circuit with BI‐3802 or downstream inhibitors (Fatostatin/Lovastatin) overcomes abiraterone ...
Liling Jiang, Jiamin Wang, Guanjie Peng, Haichuan Zhang, Jinxin Fang, Yingyin Gao, Enzhe Lou, Yangzhou Liu, Wa Ding, Bingyuan Liu, Qiong Mao, Lizhen Jiang, Aochu Liu, Xinyue Li, Shiwen Hu, Qiaomin Ma, Yueyuan Zheng, Zhigang Zhao, Xianping Shi   +18 more
wiley   +1 more source

Studies on genome size estimation, chromosome number, gametophyte development and plant morphology of salt-tolerant halophyte Suaeda salsa. [PDF]

BMC Plant Biol, 2019
Cheng Y, Yang P, Zhao L, Priyadarshani SVGN, Zhou Q, Li Z, Li W, Xiong J, Lin Z, Li L, Huang X, Liu J, Aslam M, Zhao H, Li G, Ma J, Li L, Qin Y.   +17 more
europepmc   +1 more source

Anti‐Inflammatory Mechanisms of Selenium Nanosheets in Ulcerative Colitis: Protein Corona, GP130 Interaction, and Transcriptomic Profile

Advanced Science, EarlyView.
SeNSs provide a biocompatible, anti‐inflammatory UC therapy. SeNSs form protein coronas enriched with AKT/PI3K/NF‐κB pathway proteins, suppress GP130 via hydrophobic interactions, and inhibit pro‐inflammatory cytokines. In DSS‐induced UC mice, SeNSs reduce inflammation, tissue damage, and disease activity by modulating cytokine, chemokine, and ...
Dingyi Shen, Li Gong, Wei Yang, Jiaqi Luo, Zhen Jin, Youzhi Tang   +5 more
wiley   +1 more source

Variation in chromosome number and breeding systems: implications for diversification in Pachycereus pringlei (Cactaceae). [PDF]

Comp Cytogenet, 2018
Gutiérrez-Flores C, la Luz JLL, León FJG, Cota-Sánchez JH.   +3 more
europepmc   +1 more source

Stomatal area as an anatomical criterion for the determination of chromosome number in the <i>Eragrostis curvula</i> complex

, 1982
J. J. Spies
openalex   +2 more sources

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

Advanced Science, EarlyView.
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao, Jiawei Zhou, Chen‐Chen Wang, Zong‐Hao Wang, Nian‐Dong Mao, Meng‐Lan He, Peng‐Peng Zhang, Ping Huang, Guo‐Wei Ye, Yu‐Qing Zhang, Feng‐Hui Tang, Hang Zhang, Tian Xie, Xiang‐Yang Ye   +13 more
wiley   +1 more source

Evolutionary mechanisms of runaway chromosome number change in Agrodiaetus butterflies. [PDF]

Sci Rep, 2017
Vershinina AO, Lukhtanov VA.
europepmc   +1 more source

Chromosome number instability in Phalaris L.

, 1985
Maria Teresa Schifino, Carla C. Zanella, Rejone Gus   +2 more
openalex   +2 more sources

A Novel OsMPK6‐OsMADS47‐PPKL1/3 Module Controls Grain Shape and Yield in Rice

Advanced Science, EarlyView.
OsMADS47 is identified as a key regulator governing rice grain morphology. Phosphorylation‐dependent regulation of its activity directs the development of slender versus round grains, modulating both yield and appearance. This mechanism bridges cellular signaling with transcriptional regulation, establishing a molecular framework for grain optimization.
Jingjing Fang, Yan Chun, Fan Zhang, Tingting Guo, Mengmeng Ren, Jinfeng Zhao, Shoujiang Yuan, Wensheng Wang, Yunhai Li, Xueyong Li   +9 more
wiley   +1 more source

chromploid: An R package for chromosome number evolution across the plant tree of life. [PDF]

Appl Plant Sci, 2018
Zenil-Ferguson R, Burleigh JG, Ponciano JM.   +2 more
europepmc   +1 more source