Results 111 to 120 of about 840,795 (338)

Chromosome painting and phylogenetic analysis suggest that the genus Lophostoma (Chiroptera, Phyllostomidae) is paraphyletic

Scientific Reports, 2022
The subfamily Phyllostominae (Chiroptera, Phyllostomidae) comprises 10 genera of Microchiroptera bats from the Neotropics. The taxonomy of this group is controversial due to incongruities in the phylogenetic relationships evident from different datasets.
Natalia Karina Nascimento da Silva, Cleusa Yoshiko Nagamachi, Luis Reginaldo Ribeiro Rodrigues, Patricia Caroline Mary O’Brien, Fengtang Yang, Malcolm Andrew Ferguson-Smith, Julio Cesar Pieczarka   +6 more
doaj   +1 more source

Intra-Chromosomal Potentials from Nucleosomal Positioning Data [PDF]

arXiv, 2021
No systematic method exists to derive intra-chromosomal potentials between nucleosomes along a chromosome consistently across a given genome. Such potentials can yield information on nucleosomal ordering, thermal as well as mechanical properties of chromosomes.
arxiv  

Metaphase and Interphase Cytogenetics with Alu-PCR-amplified Yeast Artificial Chromosome Clones Containing the BCR Gene and the Protooncogenes c-raf-1, c-fms, and c-erbB-21 [PDF]

, 1992
A human yeast artificial chromosome (YAC) library was screened by polymerase chain reaction with oligonucleotide primers defined for DNA sequences of the BCR gene and the protooncogenes c-raf-1, c-fms, and c-erB-2.
Becher, Reinhard, Cremer, Thomas, Green, Eric D., Konecki, David, Lengauer, Christoph, Olson, Maynard V., Riethman, Harold C., Speicher, Michael R., Taniwaki, Masafumi   +8 more
core  

Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes [PDF]

, 2010
Copyright: © 2010 Stimpson et al.Genome rearrangement often produces chromosomes with two centromeres (dicentrics) that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, and particularly
A Henderson, A Hill, A Krystosek, A Smogorzewska, AH Sturtevant, AK Sinha, AL Lam, Anna Jauch, AW Higgins, AW Higgins, AW Lo, B McClintock, B van Steensel, BA Sullivan, BA Sullivan, BA Sullivan, BA Sullivan, BA Sullivan, BE Black, BE Black, Beth A. Sullivan, C Mann, C Pondarre, C Shiels, C Tyler-Smith, CH Gravholt, D Granick, D Hanahan, D Koshland, DJ Wolff, DK Palmer, DK Palmer, DR Foltz, DR Foltz, E Novitski, E Therman, EM Dunleavy, F Han, F Mitelman, F Mitelman, F Mitelman, GB Celli, GM Greig, Gregory P. Copenhaver, HE Trowell, Heidi Holtgreve-Grez, HF Willard, Ihn Young Song, J Hamerton, J Karlseder, J Karlseder, J Lange, J Pampalona, J Waye, JA Brock, JA Croft, JA Evans, JA Hackett, JE Sylvester, JJ Roix, JM Bridger, JM Craig, JM Spence, Joanna M. Bridger, K Ahmad, K Bross, K Mizuno, Kaitlin M. Stimpson, Karen E. Hayden, KH Choo, M Krzywinski, MD Blower, MD Blower, MG Schueler, MJ Ramirez, MR Branco, MR Lowden, NC Steiner, P Maraschio, PB Vagnarelli, PE Warburton, PE Warburton, S Cardinale, S Schwartz, S Spadari, S Zhang, SF Louis, SL Page, T Dousset, T Haaf, T Hori, TC Hsu, W Robertson, WC Earnshaw, WC Earnshaw, XY Guan, YZ Zheng   +96 more
core   +4 more sources

Vertical inhibition of p110α/AKT and N‐cadherin enhances treatment efficacy in PIK3CA‐aberrated ovarian cancer cells

Molecular Oncology, Volume 19, Issue 4, Page 1132-1154, April 2025.
PIK3CA amplification and PIK3CA mutation enhance ovarian tumorigenicity through an activation of AKT, which phosphorylates YAP at Ser127. This Ser127 phosphorylation leads to the retention of YAP in the cytoplasm and triggers RAC1 activity, promoting cell migration. Additionally, AKT activation increases expression of N‐cadherin, which further enhances
Shibo Zhang, Hei Ip Hong, Victor C. Y. Mak, Yuan Zhou, Yiling Lu, Guanglei Zhuang, Lydia W. T. Cheung   +6 more
wiley   +1 more source

A Robust Framework of Chromosome Straightening with ViT-Patch GAN [PDF]

arXiv, 2022
Chromosomes carry the genetic information of humans. They exhibit non-rigid and non-articulated nature with varying degrees of curvature. Chromosome straightening is an important step for subsequent karyotype construction, pathological diagnosis and cytogenetic map development.
arxiv  

Unraveling epigenetic heterogeneity across gastrointestinal adenocarcinomas through a standardized analytical framework

Molecular Oncology, Volume 19, Issue 4, Page 1117-1131, April 2025.
This study shows that patients with gastrointestinal adenocarcinomas can be stratified into six distinct subtypes based on genome‐scale DNA methylation profiling. This stratification, achieved using a robust analytical framework, aligns with established tumor characteristics and holds potential to support prognostication.
Rita Pinto, Hege Marie Vedeld, Guro Elisabeth Lind, Marine Jeanmougin   +3 more
wiley   +1 more source

Resolving the degree of order in the bacterial chromosome using a statistical physics approach [PDF]

arXiv, 2020
While bacterial chromosomes were long thought to be amorphous, recent experiments reveal pronounced organizational features. However, the extent of bacterial chromosome organization remains unclear. Here, we develop a fully data-driven maximum entropy approach to extract the distribution of single-cell chromosome conformations from experimental ...
arxiv  

Using Orientation to Distinguish Overlapping Chromosomes [PDF]

arXiv, 2022
A difficult step in the process of karyotyping is segmenting chromosomes that touch or overlap. In an attempt to automate the process, previous studies turned to Deep Learning methods, with some formulating the task as a semantic segmentation problem. These models treat separate chromosome instances as semantic classes, which we show to be problematic,
arxiv  

Interphase chromosome positioning in in vitro porcine cells and ex vivo porcine tissues [PDF]

, 2012
Copyright @ 2012 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and 85 reproduction in any medium, provided the original author and source
A Bolzer, A Fiebig, BM Skinner, C Federico, CK Lee, D Koehler, Darren K Griffin, DJ Prockop, FA Habermann, FH Gage, G Rettenberger, GA Rohrer, GM Cooper, H Ellegren, H Tanabe, H Tanabe, H Telenius, H Telenius, HA Foster, HA Foster, HA McQueen, HB Sun, Helen A Foster, I Szczerbal, IS Mehta, IS Mehta, J Ferreira, JA Croft, JM Bridger, JM Bridger, JM Craig, JM Craig, Joanna M Bridger, KJ Meaburn, KJ Meaburn, KJ Meaburn, L Mora, L Parada, L Schook, LA Parada, M Cremer, M Cremer, M Ferrari, M Knight, M Kuroda, M Neusser, M Yerle-Bouissou, N Gilbert, O Alexandrova, R Mayer, S Boyle, T Cremer, T Cremer, T Misteli, WA Bickmore, Z Jiang   +55 more
core   +2 more sources