Results 201 to 210 of about 840,795 (338)

ZMYND8 Reads H3K36me2 to Activate CEBPE Transcription and Suppress Multiple Myeloma Progression through the Inhibition of Adaptive UPR Pathways

open access: yesAdvanced Science, EarlyView.
Zinc‐finger MYND‐type‐containing 8 (ZMYND8) activates the transcription of CCAAT/enhancer‐binding protein epsilon by recognizing dimethylation of lysine 36 in histone H3 through its Pro‐Trp‐Trp‐Pro domain, thereby inhibiting adaptive unfolded protein response pathways to suppress the proliferation and invasion of multiple myeloma (MM) cells ...
Jiaxuan Xu   +14 more
wiley   +1 more source

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

open access: yesAdvanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin   +21 more
wiley   +1 more source

Comparative Karyotype of Pig and Cattle Using Whole Chromosome Painting Probes [PDF]

open access: bronze, 2004
Annette Schmitz   +5 more
openalex   +1 more source

The Nuclear Receptor NR1B1/RARα Arrests the Differentiation of Anti‐Tumor Effector Cytotoxic T Cells

open access: yesAdvanced Science, Volume 12, Issue 17, May 8, 2025.
RARα is highly expressed by differentiated effector and exhausted T cells and exerts a negative effect on effector T cell differentiation and the associated trafficking receptor switch. Upregulated RARα levels decrease the nuclear histone acetylase (HAT) activity, and this suppresses the expression of key Teff transcription factor BATF and trafficking ...
Patrick Niekamp   +5 more
wiley   +1 more source

Inverse Painting: Reconstructing The Painting Process [PDF]

open access: yesarXiv
Given an input painting, we reconstruct a time-lapse video of how it may have been painted. We formulate this as an autoregressive image generation problem, in which an initially blank "canvas" is iteratively updated. The model learns from real artists by training on many painting videos.
arxiv  

CircDNA2‐Educated YTHDF2 Phase Separation Promotes PM2.5‐Induced Malignant Transformation Through the Blunting of GADD45A Expression

open access: yesAdvanced Science, Volume 12, Issue 14, April 10, 2025.
This study unveiled the mechanism by which circDNA2‐educated YTHDF2 phase separation promotes PM2.5‐induced malignant transformation in HBE cells by blunting GADD45A expression, providing definitive evidence for the first time that LLPS is involved in the induction of tumorigenesis by particulate pollutants. Moreover, the clinical value of circDNA2 and
Jie Xu   +5 more
wiley   +1 more source

Uncovering Proximity of Chromosome Territories using Classical Algebraic Statistics [PDF]

open access: yes, 2014
Exchange type chromosome aberrations (ETCAs) are rearrangements of the genome that occur when chromosomes break and the resulting fragments rejoin with other fragments from other chromosomes.
Arsuaga, Javier   +3 more
core  

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