Results 211 to 220 of about 861,521 (343)

RanBALL: An Ensemble Machine Learning Framework for Accurate Subtype Identification of Pediatric B‐Cell Acute Lymphoblastic Leukemia

Advanced Intelligent Systems, EarlyView.
Here, we present RanBALL, an ensemble random projection‐based model for accurate and cost‐effective identification of B‐cell acute lymphoblastic leukemia subtypes is presented. By preserving patient‐to‐patient distance after dimension reduction by random projection and ensemble learning, RanBALL can facilitate the discovery of B‐ALL subtype‐specific ...
Lusheng Li, Hanyu Xiao, Xinchao Wu, Zhenya Tang, Joseph D. Khoury, Jieqiong Wang, Shibiao Wan   +6 more
wiley   +1 more source

Discovery of a First‐in‐Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity

Angewandte Chemie, EarlyView.
A covalent allosteric inhibitor M029 was discovered for SHP1, a novel target for immunotherapy. M029 binds to a cryptic Cys remote from the active site, exhibits robust target engagement, and blocks tumor progression by stimulating antitumor immune response.
Zihan Qu, Frederick Nguele Meke, Zheng Zhang, Aaron D. Krabill, Christine S. Muli, Brenson A. Jassim, Jiajun Dong, Quyen D. Nguyen, Yunpeng Bai, Jinyue Li, Yiming Miao, Bardia Asadi, Levi M. Johnson, Jinmin Miao, Darci J. Trader, W. Andy Tao, Zhong‐Yin Zhang   +16 more
wiley   +2 more sources

Correction to: Whole chromosome painting reveals independent origin of sex chromosomes in closely related forms of a fish species [PDF]

, 2017
Marcelo de Bello Cioffi, Antonio Sánchez, Juan Alberto Marchal, Nadezda Kosyakova, Thomas Liehr, Vladimir A. Trifonov, Luiz Antônio Carlos Bertollo   +6 more
openalex   +1 more source

Autosomal Dominant Erythrocytosis Caused by Non‐Renal Erythropoietin (EPO) Due to EPO c.‐136 G>A Germline Mutation

American Journal of Hematology, EarlyView.
A novel erythropoietin (EPO) promoter mutation (c.‐136 G>A) causes autosomal dominant erythrocytosis via non‐renal expression of EPO. ABSTRACT We previously reported a five‐generation kindred with autosomal dominant erythrocytosis associated with a novel germline promoter variant in the erythropoietin (EPO) gene (EPO c.‐136 G>A).
Lucie Lanikova, Dusan Hrckulak, Veronika Zimolova, Felipe R. Lorenzo, Jihyun Song, Katerina Vecerkova, Olga Babosova, Linda Berkova, Vladimir Korinek, Steve Elliott, Josef T. Prchal   +10 more
wiley   +1 more source

Microdissection and painting of asparagus L5 chromosome

, 2014
Chuan‐Liang Deng, Ruiyun Qin, Weili Zhang, Shufen Li, Wu‐Jun Gao, Lu Longdou   +5 more
openalex   +1 more source

Chromosome analysis by non-isotopic in situ hybridization. [PDF]

, 1992
Cremer, Thomas, Lichter, Peter, Rooney, Denise E.   +2 more
core   +1 more source

Genotypes and Phenotypes of Patients With TSPEAR‐Related Disorder: Evidence of a Predominant Dental Phenotype

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT TSPEAR (chr. 21q22.3) encodes a protein involved in tooth development and is predominantly expressed in the enamel knot. Biallelic loss of function variants in TSPEAR cause ectodermal dysplasia, tooth agenesis and sensorineural hearing loss. However, the role of TSPEAR in auditory processes is unclear.
Debora Vergani, Lucia Tiberi, Annarita Giliberti, Elia Dirupo, Laila Zaroili, Francesco Brancati, Michela Brena, Stefano Caraffi, Chiara De Luca, Livia Garavelli, Anna Virginia Gulino, Milena Mariani, Marzia Pollazzon, Angelo Selicorni, Samuela Landini, Ilaria Sani, Rosangela Artuso, Angela Peron   +17 more
wiley   +1 more source

The anatomy of a nucleus: As revealed by chromosome painting. [PDF]

PLoS Genet, 2018
Slaughter BD, Hawley RS.
europepmc   +1 more source

Chromosome Painting in Three Species of Buteoninae: A Cytogenetic Signature Reinforces the Monophyly of South American Species

, 2013
Edivaldo Herculano Corrêa de Oliveira, Marcella Mergulhão Tagliarini, Michelly S. dos Santos, Patrícia C. M. O’Brien, M.A. Ferguson‐Smith   +4 more
openalex   +2 more sources

Origin of B chromosomes in the genus Astyanax (Characiformes, Characidae) and the limits of chromosome painting

Zeitschrift für Induktive Abstammungs- und Vererbungslehre, 2016
Duílio M. Z. A. Silva, S. N. Daniel, J. Camacho, Ricardo Utsunomia, Francisco J. Ruiz-Ruano, Manolo Penitente, J. C. Pansonato-Alves, D. Hashimoto, C. Oliveira, F. Porto‐Foresti, F. Foresti   +10 more
semanticscholar   +1 more source