Results 221 to 230 of about 840,795 (338)

Chromosomal evolution among leaf-nosed nectarivorous bats – evidence from cross-species chromosome painting (Phyllostomidae, Chiroptera) [PDF]

, 2013
Cibele G. Sotero-Caio, Marianne Volleth, Lauren Gollahon, Beiyuan Fu, William Cheng, Bee Ling Ng, Fengtang Yang, Robert J. Baker   +7 more
openalex   +1 more source

HIC1 suppresses Tumor Progression and Enhances CD8+ T Cells Infiltration Through Promoting GSDMD‐induced Pyroptosis in Gastric Cancer

Advanced Science, EarlyView.
These findings elucidate the innovative role of HIC1 as a transcriptional activator in GC, driving the initiation of pyroptosis and enhancing CD8+ T cell infiltration, which has certain novelty and creative significance. Collectively, targeting HIC1 can present an appealing immunotherapeutic strategy to improve outcomes in GC patients.
Mengjie Kang, Wenqi Du, Lina Ding, Mengdi Wu, Dongsheng Pei   +4 more
wiley   +1 more source

Quorum Sensing Coordinates Carbon and Nitrogen Metabolism to Optimize Public Goods Production in Pseudomonas fluorescens 2P24

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Pseudomonas fluorescens 2P24 utilizes a LasI/LasR‐type quorum sensing (QS) system, MupI/MupR, to regulate carbon and nitrogen metabolism for optimal production of secondary metabolites as public goods, including 2,4‐diacetylphloroglucinol, mupirocin, and siderophores.
Jie Li, Mengxue Nie, Hongguang Ma, Xuanying Tao, Yanxia Sun, Xinyue Tu, Pingping Zhang, Li‐Qun Zhang, Rong Jia, Yong‐Xing He, Nannan Zhang, Honghua Ge   +11 more
wiley   +1 more source

Painting of fourth, a chromosome-specific protein inDrosophila

, 2001
Jan Larsson, J. Don Chen, Vanya I. Rasheva, Åsa Rasmuson-Lestander, Vincenzo Pirrotta   +4 more
openalex   +1 more source

In Vivo Nanodiamond Quantum Sensing of Free Radicals in Caenorhabditis elegans Models

Advanced Science, Volume 12, Issue 14, April 10, 2025.
The aim of this article is to demonstrate diamond‐based quantum sensing in vivo. More specifically, nitrogen vacancy centers in diamond are used for measuring free radical generation in a Huntington disease model in C. elegans. Quantum sensing allows localized measurements in the muscles and in the intestine.
Siyu Fan, Yue Zhang, Anna P. Ainslie, Renée Seinstra, Tao Zhang, Ellen Nollen, Romana Schirhagl   +6 more
wiley   +1 more source

DPImpute: A Genotype Imputation Framework for Ultra‐Low Coverage Whole‐Genome Sequencing and its Application in Genomic Selection

Advanced Science, Volume 12, Issue 16, April 24, 2025.
DPImpute is a two‐step pipeline that outperforms existing tools in whole‐genome SNP imputation, particularly under conditions of ultra‐low coverage sequencing, small sample sizes, and limited references. It enables precise imputation for single blastocyst cells, supporting genomic selection at the pre‐implantation stage.
Weigang Zheng, Wenlong Ma, Zhilong Chen, Chao Wang, Tao Sun, Wenjun Dong, Wenjing Zhang, Song Zhang, Zhonglin Tang, Kui Li, Yunxiang Zhao, Yuwen Liu   +11 more
wiley   +1 more source

Integrating Dense Genotyping with High‐Throughput Phenotyping Empowers the Genetic Dissection of Berry Quality and Resilience Traits in Grapevine

Advanced Science, EarlyView.
Researchers develop advanced tools to study grapevine traits like berry quality and stress resilience. A 200K SNP array and high‐throughput phenotyping enable the identification of loci linked to berry shape, sugar content, acidity, and cold tolerance. Functional validation of genes such as NAC08 reveals roles in cold tolerance.
Yuyu Zhang, Yongjian Wang, Michael Henke, Pablo Carbonell‐Bejerano, Zemin Wang, Pierre‐François Bert, Yi Wang, Huayang Li, Junhua Kong, Peige Fan, Zhanwu Dai, Zhenchang Liang   +11 more
wiley   +1 more source

Paintig of defined chromosomal regions by in situ suppression hybridization of libraries from laser-microdissected chromosomes [PDF]

, 1991
Cremer, Thomas, Eckelt, A., Endlich, N., Greulich, K. O., Lengauer, Christoph, Lichter, Peter, Ponelies, N., Weith, A.   +7 more
core   +1 more source

Deciphering the Oncogenic Landscape of Hepatocytes Through Integrated Single‐Nucleus and Bulk RNA‐Seq of Hepatocellular Carcinoma

Advanced Science, Volume 12, Issue 14, April 10, 2025.
By combining snRNA‐seq and bulk RNA‐seq, this study identified key hepatocyte subtypes, genes, and pathways in HCC. It established a Quantile Distribution Model, providing potential targets for HCC diagnosis and treatment. It categorized HCC into metabolic, inflammatory, and matrix classes, each with sensitive drugs identified.
Huanhou Su, Xuewen Zhou, Guanchuan Lin, Chaochao Luo, Wei Meng, Cui Lv, Yuting Chen, Zebin Wen, Xu Li, Yongzhang Wu, Changtai Xiao, Jian Yang, Jiameng Lu, Xingguang Luo, Yan Chen, Paul KH Tam, Chuanjiang Li, Haitao Sun, Xinghua Pan   +18 more
wiley   +1 more source

Genomic Insights into Post‐Domestication Expansion and Selection of Body Size in Ponies

Advanced Science, Volume 12, Issue 16, April 24, 2025.
The authors’ research delves into the history of ponies by assembling a pony genome and integrating horse genomes. This unveils genetic connections between Asian and European pony breeds. Cis‐regulatory elements of key genes impacting body size are also identified.
Xingzheng Li, Zihao Wang, Min Zhu, Binhu Wang, Shaohua Teng, Jing Yan, Haoyu Wang, Pengxiang Yuan, Shuwei Cao, Xiaolu Qu, Zhen Wang, Kai Zhan, Md. Panir Choudhury, Xintong Yang, Qi Bao, Sang He, Lei Liu, Pengju Zhao, Jicai Jiang, Hai Xiang, Lingzhao Fang, Zhonglin Tang, Yuying Liao, Guoqiang Yi   +23 more
wiley   +1 more source