Results 81 to 90 of about 81,359 (292)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Meiotic sex chromosome cohesion and autosomal synapsis are supported by Esco2.

, 2020
In mitotic cells, establishment of sister chromatid cohesion requires acetylation of the cohesin subunit SMC3 (acSMC3) by ESCO1 and/or ESCO2. Meiotic cohesin plays additional but poorly understood roles in the formation of chromosome axial elements (AEs)
Biswas, U., Eichele, G., Hempel, K., Jessberger, R., Kühnel, A., McNicoll, F., Whelan, G.   +6 more
core   +1 more source

Meiotic behavior of two polyploid species of genus Pleurodema (Anura: Leiuperidae) from central Argentina [PDF]

, 2014
Polyploidy is an important evolutionary force but rare in vertebrates. However, in anurans, the genus Pleurodema has polyploid species, two of them tetraploid and one octoploid.
Grenat, Pablo Raúl, Martino, Adolfo Ludovico, Otero, Manuel Alejandro, Salas, Nancy Edith, Valetti, Julian Alonso   +4 more
core   +2 more sources

The transcriptional basis of chromosome pairing

Journal of Cell Science, 1997
ABSTRACT Pairing between homologous chromosomes is essential for successful meiosis; generally only paired homologs recombine and segregate correctly into haploid germ cells. Homologs also pair in some somatic cells (e.g. in diploid and polytene cells of Drosophila). How homologs find their partners is a mystery.
openaire   +3 more sources

X-inactivation by chromosomal pairing events [PDF]

Genes & Development, 1999
X-inactivation is the coordinated silencing of nearly all genes on one of the two X chromosomes in female mammals. X-inactivation requires the cis-acting Xist gene. The highly unusual properties of Xist and the extremely long distances over which Xist acts have made it difficult to reconcile X-inactivation with other examples of gene regulation.
openaire   +2 more sources

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

New cytogenetic data on Nabidae (Heteroptera: Cimicomorpha), with a discussion of karyotype variation and meiotic patterns, and their taxonomic significance

European Journal of Entomology, 2004
As a part of ongoing cytogenetic studies on the bug family Nabidae (Heteroptera), the karyotypes and meiotic patterns of male Nabis (Aspilaspis) viridulus Spinola, 1837, N.
Valentina G. KUZNETSOVA, Snejana GROZEVA, Seppo NOKKALA   +2 more
doaj   +1 more source

Epigenetic-structural changes in X chromosomes promote Xic pairing during early differentiation of mouse embryonic stem cells

Biophysics and Physicobiology, 2022
X chromosome inactivation center (Xic) pairing occurs during the differentiation of embryonic stem (ES) cells from female mouse embryos, and is related to X chromosome inactivation, the circadian clock, intra-nucleus architecture, and metabolism. However,
Tetsushi Komoto, Masashi Fujii, Akinori Awazu   +2 more
doaj   +1 more source

TRIP13PCH-2 promotes Mad2 localization to unattached kinetochores in the spindle checkpoint response. [PDF]

, 2015
The spindle checkpoint acts during cell division to prevent aneuploidy, a hallmark of cancer. During checkpoint activation, Mad1 recruits Mad2 to kinetochores to generate a signal that delays anaphase onset.
Bhalla, Needhi, Chen, Pin-Hsi, Hwang, Tom, Nelson, Christian R   +3 more
core   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +15 more
wiley   +1 more source