Results 61 to 70 of about 81,359 (292)

Oligopaint DNA FISH reveals telomere-based meiotic pairing dynamics in the silkworm, Bombyx mori.

PLoS Genetics, 2021
Accurate chromosome segregation during meiosis is essential for reproductive success. Yet, many fundamental aspects of meiosis remain unclear, including the mechanisms regulating homolog pairing across species.
Leah F Rosin, Jose Gil, Ines A Drinnenberg, Elissa P Lei   +3 more
doaj   +1 more source

Transfer of the ph1b Deletion Chromosome 5B From Chinese Spring Wheat Into a Winter Wheat Line and Induction of Chromosome Rearrangements in Wheat-Aegilops biuncialis Hybrids

Frontiers in Plant Science, 2022
Effective utilization of genetic diversity in wild relatives to improve wheat requires recombination between wheat and alien chromosomes. However, this is suppressed by the Pairing homoeologous gene, Ph1, on the long arm of wheat chromosome 5B.
Edina Türkösi, László Ivanizs, András Farkas, Eszter Gaál, Klaudia Kruppa, Péter Kovács, Péter Kovács, Éva Szakács, Kitti Szőke-Pázsi, Mahmoud Said, Mahmoud Said, Petr Cápal, Simon Griffiths, Jaroslav Doležel, István Molnár   +14 more
doaj   +1 more source

Evidence that MEK1 positively promotes interhomologue double-strand break repair [PDF]

, 2010
During meiosis there is an imperative to create sufficient crossovers for homologue segregation. This can be achieved during repair of programmed DNA double-strand breaks (DSBs), which are biased towards using a homologue rather than sister chromatid as ...
Bishop-Bailey, A, Goldman, A.S.H, Johnson, R, Khisroon, M, Neale, Matt, Tarentyev, Y   +5 more
core   +1 more source

Finding the Correct Partner: The Meiotic Courtship

Scientifica, 2012
Homologous chromosomes are usually separated at the entrance of meiosis; how they become paired is one of the outstanding mysteries of the meiotic process.
Tomás Naranjo
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

An increasing need for productive and stress resilient Festulolium amphiploids: what can be learnt from the stable genomic composition of Festuca pratensis subsp. apennina (De Not.) Hegi?

Frontiers in Environmental Science, 2016
Genome composition of Festuca pratensis subsp. apennina (De Not.) Hegi, a tetraploid fescue species native to the tall forbs communities of south-eastern Europe at altitudes between 1100 and 2200m a.s.l.
David Kopecký, John Harper, Jan Bartoš, Dagmara Gasior, Jan Vrána, Eva Hřibová, Beat Boller, Nicola Ardenghi, Denisa Šimoníková, Jaroslav Doležel, Michael (Mike) Warren Humphreys   +10 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

HAL-2 promotes homologous pairing during Caenorhabditis elegans meiosis by antagonizing inhibitory effects of synaptonemal complex precursors.

PLoS Genetics, 2012
During meiosis, chromosomes align with their homologous pairing partners and stabilize this alignment through assembly of the synaptonemal complex (SC). Since the SC assembles cooperatively yet is indifferent to homology, pairing and SC assembly must be ...
Weibin Zhang, Natasha Miley, Michael S Zastrow, Amy J MacQueen, Aya Sato, Kentaro Nabeshima, Enrique Martinez-Perez, Susanna Mlynarczyk-Evans, Peter M Carlton, Anne M Villeneuve   +9 more
doaj   +1 more source

Surveillance of cohesin-supported chromosome structure controls meiotic progression

Nature Communications, 2020
Meiosis-specific cohesins and the synaptonemal complex are essential for meiotic chromosome structure and function. Here the authors show that continued surveillance of these chromosome structures controls meiotic progression by regulating CHK-2, a ...
Maikel Castellano-Pozo, Sarai Pacheco, Georgios Sioutas, Angel Luis Jaso-Tamame, Marian H. Dore, Mohammad M. Karimi, Enrique Martinez-Perez   +6 more
doaj   +1 more source

Dynamics of DNA replication during premeiosis and early meiosis in wheat. [PDF]

PLoS ONE, 2014
Meiosis is a specialised cell division that involves chromosome replication, two rounds of chromosome segregation and results in the formation of the gametes.
María-Dolores Rey, Pilar Prieto
doaj   +1 more source