Results 51 to 60 of about 42,068 (256)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Introgression of the Aegilops speltoides Su1-Ph1 Suppressor into Wheat
Frontiers in Plant Science, 2017 Meiotic pairing between homoeologous chromosomes in polyploid wheat is inhibited by the Ph1 locus on the long arm of chromosome 5 in the B genome.
Hao Li +5 more
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Sequence analysis of wheat subtelomeres reveals a high polymorphism among homoeologous chromosomes
The Plant Genome, 2020 Bread wheat, Triticum aestivum L., is one of the most important crops in the world. Understanding its genome organization (allohexaploid; AABBDD; 2n = 6x = 42) is essential for geneticists and plant breeders. Particularly, the knowledge of how homologous
Miguel Aguilar, Pilar Prieto
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Synaptonemal complex components persist at centromeres and are required for homologous centromere pairing in mouse spermatocytes. [PDF]
PLoS Genetics, 2012 Recent studies in simple model organisms have shown that centromere pairing is important for ensuring high-fidelity meiotic chromosome segregation. However, this process and the mechanisms regulating it in higher eukaryotes are unknown.
C Gaston Bisig +6 more
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A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline
FEBS Open Bio, EarlyView.Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey +4 more
wiley +1 more source
X-inactivation by chromosomal pairing events [PDF]
Genes & Development, 1999 X-inactivation is the coordinated silencing of nearly all genes on one of the two X chromosomes in female mammals. X-inactivation requires the cis-acting Xist gene. The highly unusual properties of Xist and the extremely long distances over which Xist acts have made it difficult to reconcile X-inactivation with other examples of gene regulation.
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FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
European Journal of Entomology, 2004 As a part of ongoing cytogenetic studies on the bug family Nabidae (Heteroptera), the karyotypes and meiotic patterns of male Nabis (Aspilaspis) viridulus Spinola, 1837, N.
Valentina G. KUZNETSOVA +2 more
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Biophysics and Physicobiology, 2022 X chromosome inactivation center (Xic) pairing occurs during the differentiation of embryonic stem (ES) cells from female mouse embryos, and is related to X chromosome inactivation, the circadian clock, intra-nucleus architecture, and metabolism. However,
Tetsushi Komoto +2 more
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The transcriptional basis of chromosome pairing
Journal of Cell Science, 1997 ABSTRACT Pairing between homologous chromosomes is essential for successful meiosis; generally only paired homologs recombine and segregate correctly into haploid germ cells. Homologs also pair in some somatic cells (e.g. in diploid and polytene cells of Drosophila). How homologs find their partners is a mystery.
openaire +3 more sources