Results 241 to 250 of about 145,292 (281)

System level network data and models attack cancer drug resistance

British Journal of Pharmacology, EarlyView.
Drug resistance is responsible for >90% of cancer related deaths. Cancer drug resistance is a system level network phenomenon covering the entire cell. Small‐scale interactomes and signalling network models of drug resistance guide directed drug development.
Márk Kerestély, Dávid Keresztes, Levente Szarka, Borbála M. Kovács, Klára Schulc, Dániel V. Veres, Peter Csermely   +6 more
wiley   +1 more source

Genomic characterization of azithromycin-resistant and extended-spectrum β-lactamase-producing <i>Shigella flexneri</i> 2a from two clinical isolates in Japan. [PDF]

JAC Antimicrob Resist
Kobayashi Y, Umeda S, Takahashi K, Shibata S, Shibayama K, Suzuki M.   +5 more
europepmc   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

The role of toxin/antidote genes in the maintenance and evolution of accessory chromosomes in Fusarium. [PDF]

Genetics
Sandell L, Forsythe A, Mirandola A, Jorayev S, Urquhart AS, Granger Farbos A, Saupe SJ, Vogan AA.   +7 more
europepmc   +1 more source

LncRNA H19‐Encoded Micropeptide altH19 Promotes DNA Replication and Mitosis in Myeloma Cells by Enhancing the Phosphorylation of CDK2 at Threonine 160

Cell Proliferation, EarlyView.
The micropeptide altH19 interacts with phosphorylated CDK2 (p‐CDK2), subsequently activating CDK2 phosphorylation. This enhances the downstream E2F1 target gene RB activity, which accelerates DNA replication, ultimately leading to rapid myeloma cell mitosis and proliferation.
Yaxin Zhang, Wenjing Li, Xu Cao, Jiwei Mao, Xiaodan Zhou, Linlin Liu, Ruosi Yao   +6 more
wiley   +1 more source

Completed genomes from <i>Variovorax</i> provide insight into genome diversification through horizontal gene transfer. [PDF]

Curr Res Microb Sci
Ville CJN, Orwin PM.
europepmc   +1 more source

Phage-encoded TelN inhibits bacterial Mre11-Rad50 nuclease to protect hairpin telomeres. [PDF]

EMBO J
Houmel M, Pellaton N, Anchimiuk A, Gruber S.   +3 more
europepmc   +1 more source

Mobile genetic elements in shaping <i>Klebsiella pneumoniae</i> pathogenicity. [PDF]

Front Microbiol
Li Y, Farzana R.
europepmc   +1 more source

Involvement of the inner surface residues of bacterial SMC protein MukB in the ssDNA binding in vitro. [PDF]

Commun Biol
Akiyama K, Yano K, Niki H.
europepmc   +1 more source

Uropathogenic Escherichia coli proliferate as a coccoid morphotype inside human host cells. [PDF]

PLoS Biol
Pokhrel A, Chisholm L, Costas A, Pittorino M, Duggin IG, Söderström B.   +5 more
europepmc   +1 more source