Results 91 to 100 of about 1,205,521 (283)

An early modern human from Romania with a recent Neanderthal ancestor

Nature, 2015
Neanderthals are thought to have disappeared in Europe approximately 39,000–41,000 years ago but they have contributed 1–3% of the DNA of present-day people in Eurasia.
Qiaomei Fu, M. Hajdinjak, O. Moldovan, S. Constantin, Swapan Mallick, P. Skoglund, N. Patterson, N. Rohland, Iosif Lazaridis, B. Nickel, B. Viola, Kay Prüfer, M. Meyer, J. Kelso, D. Reich, S. Pääbo   +15 more
semanticscholar   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Inhibitory Effect of Nano-oligonucleotides as a New Nanotechnology Method in Gene Therapy of Leukemia In Vitro [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2011
Background and Objectives: Gene therapy is a new and specific method for therapy of leukemia. Antitelomerase agents can be used in cancer therapy. Telomeres are specialized heterochromatin structures that act as protective caps at the ends of linear ...
N Naghsh, M Salehi, M Rabbani
doaj   +1 more source

TAURODONTISM AND KLINEFELTER SYNDROME: CASE REPORT AND REVIEW OF THE LITERATURE

Cumhuriyet Dental Journal, 2014
This paper presents aseven-year old patient with Klinefelter Syndrome who needs dental treatmentbecause of pain in his teeth. The patient had mildmental retardation, learning and speaking difficulties, taurodonticteeth, missing premolars and incisor ...
Fatih Öznurhan
doaj   +1 more source

Identification of an interchromosomal compartment by polymerization of nuclear-targeted vimentin [PDF]

, 1998
A number of structural and functional subnuclear compartments have been described, including regions exclusive of chromosomes previously hypothesized to form a reactive nuclear space.
Bridger, JM, Herrmann, H, Lichter, P, Muenkel, C   +3 more
core  

Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation

, 2020
X‐chromosome inactivation ensures dosage compensation between the sexes in mammals by randomly choosing one out of the two X chromosomes in females for inactivation.
Barr M. L., Comings D. E., Delbrück M., Rastan S., Rosspopoff O.   +4 more
core   +1 more source

Human Spermatogenic Failure Purges Deleterious Mutation Load from the Autosomes and Both Sex Chromosomes, including the Gene DMRT1

PLoS Genetics, 2013
Gonadal failure, along with early pregnancy loss and perinatal death, may be an important filter that limits the propagation of harmful mutations in the human population.
A. Lopes, K. Aston, E. Thompson, F. Carvalho, J. Gonçalves, N. Huang, R. Matthiesen, M. J. Noordam, I. Quintela, Avinash Ramu, C. Seabra, Amy B. Wilfert, J. Dai, J. M. Downie, S. Fernandes, Xuejiang Guo, J. Sha, A. Amorim, A. Barros, Á. Carracedo, Zhibin Hu, M. Hurles, S. Moskovtsev, C. Ober, D. Paduch, J. Schiffman, P. Schlegel, M. Sousa, D. Carrell, D. Conrad   +29 more
semanticscholar   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source