Results 91 to 100 of about 245,879 (248)

Human Chromosomes

, 2012
An interactive e-learning resource to explore Human Chromosomes and the consequences of changes in chromosome number to health and development.
Richard Flint
core  

Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization [PDF]

, 1994
We analyzed 19 chromophobe renal cell carcinomas by means of comparative genomic hybridization. Two tumors revealed no numerical abnormalities. In the remaining 17 cases we found loss of entire chromosomes with underrepresentation of chromosome 1 ...
Speicher, Michael R., Cremer, Thomas, Kovacs, Gyula, Störkel, S., Ried, Thomas, Schoell, B., Manoir, Stanislas du, Schröck, Evelin   +7 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Bayesian data driven modelling of kinetochore dynamics: Space-time organisation of the human metaphase plate.

PLoS Computational Biology
Mitosis is a complex self-organising process that achieves high fidelity separation of duplicated chromosomes into two daughter cells through capture and alignment of chromosomes to the spindle mid-plane.
Constandina Koki, Alessio V Inchingolo, Abdullahi Daniyan, Enyu Li, Andrew D McAinsh, Nigel J Burroughs   +5 more
doaj   +1 more source

High-level detection of gene amplification and chromosome aneuploidy in extracted nuclei from paraffin-embedded tissue of human cancer using FISH: a new approach for retrospective studies

European Journal of Histochemistry, 2009
A novel application of fluorescence in situ hybridization (FISH) to isolated nuclei is described. The method detects gene amplification and chromosome aneuploidy in extracted nuclei from paraffin-embedded tissue of human cancer with greater sensitivity ...
E Rossi, A Ubiali, P Balzarini, M Cadei, F Alpi, PG Grigolato   +5 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Inhibitory Effect of Nano-oligonucleotides as a New Nanotechnology Method in Gene Therapy of Leukemia In Vitro [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2011
Background and Objectives: Gene therapy is a new and specific method for therapy of leukemia. Antitelomerase agents can be used in cancer therapy. Telomeres are specialized heterochromatin structures that act as protective caps at the ends of linear ...
N Naghsh, M Salehi, M Rabbani
doaj   +1 more source

TAURODONTISM AND KLINEFELTER SYNDROME: CASE REPORT AND REVIEW OF THE LITERATURE

Cumhuriyet Dental Journal, 2014
This paper presents aseven-year old patient with Klinefelter Syndrome who needs dental treatmentbecause of pain in his teeth. The patient had mildmental retardation, learning and speaking difficulties, taurodonticteeth, missing premolars and incisor ...
Fatih Öznurhan
doaj   +1 more source

Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisomerase IIα [PDF]

, 2012
© 2012 Samejima et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication dateMitotic chromosome formation involves a relatively minor ...
Cooke, C.A., Lydia C. Green, Itaru Samejima, Flavia de Lima Alves, Farr, CJ, Samejima, I., Earnshaw, W.C., Samejima, K., Vagnarelli, P., Kelly, D.A., Kerr, A., David A. Kelly, Hudson, DF, Hudson, D.F., Carol A. Cooke, Kerr, A, Vargiu, G., Cooke, CA, Giulia Vargiu, Hiromi Ogawa, Green, LC, Alves, FDL, Damien F. Hudson, Ogawa, H, de Lima Alves, F, Ogawa, H., Alves, F.L., Green, L.C., Vagnarelli, P, Kumiko Samejima, Ohta, S, Alastair Kerr, Christine J. Farr, Shinya Ohta, William C. Earnshaw, Vargiu, G, Ohta, S., Farr, C.J., Paola Vagnarelli, Juri Rappsilber, Rappsilber, J., Samejima, I, Kelly, DA, Rappsilber, J, Samejima, K, Earnshaw, WC   +45 more
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source