Results 151 to 160 of about 1,205,521 (283)

The complete sequence of a human Y chromosome

bioRxiv, 2023
A. Rhie, S. Nurk, Monika Cechova, Savannah J. Hoyt, Dylan J. Taylor, Nicolas Altemose, P. Hook, S. Koren, M. Rautiainen, I. Alexandrov, J. Allen, Mobin Asri, Andrey V. Bzikadze, Nae-Chyun Chen, Chen-Shan Chin, M. Diekhans, Paul Flicek, G. Formenti, Arkarachai Fungtammasan, C. G. Girón, Erik K. Garrison, Ariel Gershman, J. Gerton, Patrick G. S. Grady, A. Guarracino, Leanne Haggerty, R. Halabian, Nancy F. Hansen, Robert S. Harris, Gabrielle Hartley, William T. Harvey, Marina Haukness, Jakob M. Heinz, Thibaut Hourlier, R. Hubley, S. Hunt, Stephen Hwang, Miten Jain, Rupesh K. Kesharwani, Alexandra P. Lewis, Heng Li, Glennis A. Logsdon, Julian K. Lucas, W. Makałowski, C. Markovic, Fergal J. Martin, Ann M. Mc Cartney, R. McCoy, Jennifer McDaniel, B. McNulty, P. Medvedev, Alla Mikheenko, Katherine M. Munson, T. Murphy, Hugh E. Olsen, Nathan D. Olson, L. F. Paulin, David Porubsky, T. Potapova, Fedor Ryabov, S. Salzberg, M. Sauria, F. Sedlazeck, Kishwar Shafin, V. Shepelev, Alaina Shumate, Jessica M. Storer, Likhitha Surapaneni, A. M. Taravella Oill, F. Thibaud-Nissen, W. Timp, Marta Tomaszkiewicz, Mitchell R. Vollger, B. Walenz, Allison C. Watwood, Matthias H. Weissensteiner, A. Wenger, M. Wilson, Samantha Zarate, Yiming Zhu, J. Zook, E. Eichler, R. O’Neill, M. Schatz, K. Miga, K. Makova, A. Phillippy   +86 more
semanticscholar   +1 more source

Ultrasound in Women's Health: Mechanisms, Applications, and Emerging Opportunities

Advanced Materials, EarlyView.
As healthcare moves toward decentralization, ultrasound technologies are evolving from strictly imaging tools in clinical settings into versatile diagnostic and therapeutic platforms, with growing roles addressing women's health needs. This review highlights how ultrasound's underlying physical mechanisms can be harnessed to reduce disparities in women'
Sarah B. Ornellas, Bilal Kizilaslan, Aastha Shah, Jason F. Hou, Yoonsoo Shin, Alejandra Hernandez Moyers, Claudia Lozano, Canan Dagdeviren   +7 more
wiley   +1 more source

Human primordial, primary and secondary ovarian follicles in long-term culture: effect of partial isolation.

Human Reproduction, 1999
O. Hovatta, Catherine S. Wright, T. Krausz, K. Hardy, R. Winston   +4 more
semanticscholar   +1 more source

Decoding the Cellular Heterogeneity and Malignant Progression of Human Penile Squamous Cell Carcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
Single‐cell transcriptomic and functional analyses identify SEMA3C as a key regulator of tumor progression and tumor microenvironment remodeling in penile squamous cell carcinoma. SEMA3C promotes epithelial–mesenchymal transition, tumor growth, and invasion while shaping an immunosuppressive microenvironment, highlighting its potential as a prognostic ...
Xiheng Hu, Wensheng Shi, Liang Dong, Lingjuan Huang, Xiyuan Zhang, Yiting Feng, Jie Sun, Lanlan Liu, Teng Liu, Jun Fu, Bowen Zhong, Qihao Leng, Xiaohua Wu, Minfeng Chen, Lingfang Li, Yuan Li, Xin Jin, Long Wang, Jian Cao, Xin Li, Mingzhu Yin, Xiang Chen   +21 more
wiley   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort.

American Journal of Human Genetics, 1999
Jochen Hampe, S. Schreiber, S. Shaw, Kit F. Lau, S. Bridger, A. Macpherson, L. Cardon, H. Sakul, T. Harris, A. Buckler, Jeff Hall, P. Stokkers, S. Deventer, P. Nürnberg, Mudassar M. Mirza, John Lee, J. Lennard-Jones, C. Mathew, M. Curran   +18 more
semanticscholar   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

HUMAN SEX CHROMOSOME ABNORMALITIES IN RELATION TO DNA REPLICATION AND HETEROCHROMATINIZATION.

Proceedings of the National Academy of Sciences of the United States of America, 1963
M. Grumbach, A. Morishima, J. H. Taylor
semanticscholar   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source