Results 41 to 50 of about 357,591 (221)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Molecular breakpoint cloning and gene expression studies of a novel translocation t(4;15)(q27;q11.2) associated with Prader-Willi syndrome

BMC Medical Genetics, 2005
Background Prader-Willi syndrome (MIM #176270; PWS) is caused by lack of the paternally-derived copies, or their expression, of multiple genes in a 4 Mb region on chromosome 15q11.2.
Slater Howard R, Rowell Margaret, Francis David I, Northrop Emma, Albalwi Mohammed, Schüle Birgitt, Gardner RJ McKinlay, Francke Uta   +7 more
doaj   +1 more source

Chromosome Segregation Is Biased by Kinetochore Size [PDF]

, 2018
Chromosome missegregation during mitosis or meiosis is a hallmark of cancer and the main cause of prenatal death in humans. The gain or loss of specific chromosomes is thought to be random, with cell viability being essentially determined by selection ...
Aguiar, P, Almeida, A C, Damas, J, Drpic, D, Khodjakov, A, Larkin, D M, Lewin, H A, Maiato, H, Renda, F   +8 more
core   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

A Genome-wide Association Study for Somatic Cell Score Using the Illumina High-Density Bovine BeadChip Identifies Several Novel QTL Potentially Related to Mastitis Susceptibility

Frontiers in Genetics, 2013
Mastitis is an inflammation-driven disease of the bovine mammary gland that occurs in response to physical damage or infection and is one of the most costly production-related diseases in the dairy industry worldwide.
Brian eMeredith, Brian eMeredith, David eLynn, Donagh eBerry, Francis eKearney, Dan eBradley, Emma eFinlay, Alan eFahey   +7 more
doaj   +1 more source

Non-disjunction of chromosome 13 [PDF]

, 2017
We performed a molecular study with 21 microsatellites on a sample of 82 trisomy 13 conceptuses, the largest number of cases studied to date. The parental origin was determined in every case and in 89% the extra chromosome 13 was of maternal origin with ...
Bak, Mads, Brandt, Carsten A., Bruun-Petersen, Gert, Bugge, Merete, Collins, Andrew, deLozier, Celia D., Duprez, Laurence, Eiberg, Hans, Hahnemann, Johanne M.D., Hansen, Claus, Hertz, Jens Michael, Lespinasse, James, Lundsteen, Claes, Petersen, Michael B., Rasmussen, Kirsten, Tommerup, Niels, Tranebjaerg, Lisbeth   +16 more
core  

A strategy for the characterization of minute chromosome rearrangements using multiple color fluorescence in situ hybridization with chromosome-specific DNA libraries and YAC clones [PDF]

, 1993
The identification of marker chromosomes in clinical and tumor cytogenetics by chromosome banding analysis can create problems. In this study, we present a strategy to define minute chromosomal rearrangements by multicolor fluorescence in situ ...
A Kallioniemi, Anna Jauch, B Dutrillaux, C Lengauer, C Lengauer, CC Collins, Christoph Lengauer, D Pinkel, Detlev Schindler, DH Ledbetter, DH Ledbetter, GD Johnson, H Telenius, Harold C. Riethman, Helen Donis-Keller, J Grouchy de, J Sambrook, J Wiegant, JG Dauwerse, JS Heslop-Harrison, JW IJdo, Michael R. Speicher, P Lichter, P Lichter, PM Nederlof, PM Nederlof, S Manoir du, Susanne Popp, T Ried, T Ried, T Ried, Thomas Cremer   +31 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

It’s a Boy

Voices in Bioethics, 2017
On September 27, 2016 people across the world looked down at their buzzing phones to see the AP Alert: “Baby born with DNA from 3 people, first from new technique.” It was an announcement met with confusion by many, but one that polarized the scientific ...
Elizabeth Armstrong
doaj   +1 more source

Recombination dynamics of a human Y-chromosomal palindrome:rapid GC-biased gene conversion, multi-kilobase conversion tracts, and rare inversions [PDF]

, 2013
The male-specific region of the human Y chromosome (MSY) includes eight large inverted repeats (palindromes) in which arm-to-arm similarity exceeds 99.9%, due to gene conversion activity.
A Geraldes, A Scally, AJ Jeffreys, AJ Jeffreys, B Trombetta, C Batini, E Bosch, E Mancera, FO Losch, G Marais, G Marais, GA Marais, Georgina R. Bowden, H Guillon, H Skaletsky, HM Cann, IL Berg, J Lange, J Pecon Slattery, J Wang, JA Armour, JF Hughes, JF Hughes, JK Davis, JM Chen, JZ Li, K Holloway, KM Sullivan, L Duret, M Iwase, M Iwase, M Mendez-Lago, Mark A. Jobling, Mikkel H. Schierup, N Backström, N Bouzekri, Patricia Balaresque, PE Warburton, Pille Hallast, R Assis, RD Bagnall, S Repping, S Rozen, S Sarbajna, S Sengupta, SM Adams, Stéphane Ballereau, T Connallon, TM Karafet, W Shi, W Wei, Y Xue, ZH Rosser   +52 more
core   +3 more sources