Results 191 to 200 of about 68,587 (225)

RETRACTED: Polygenic risk score and prostate specific antigen predict death from prostate cancer in men with intermediate aggressive cancer

International Journal of Cancer, EarlyView.
What's New? Using 21 SNPs, two novel PRS were constructed and used to develop two new machine‐learning classifiers, one for the detection of prostate cancer and the other for the prediction of its aggressiveness and subsequent mortality. The classifier for disease detection is built using the PRS as the sole feature, whereas the one for disease ...
Leandro Rodrigues Santiago, Efthymios Ladoukakis, Dorota Scibior‐Bentkowska, Belinda Nedjai   +3 more
wiley   +1 more source

A chromosome-level genome assembly of Coryphaenoides armatus. [PDF]

Sci Data
Wu B, Yu H, Luo T, Lu B, Lin Q, Zhang Y.
europepmc   +1 more source

Gene signatures characterizing driver mutations in lung squamous carcinoma are predictive of the progression of pre‐cancer lesions

International Journal of Cancer, EarlyView.
What's New? Lung squamous cell carcinoma (LUSC) is more aggressive than lung adenocarcinoma, and is most often diagnosed at an advanced stage. Here, the authors evaluated gene expression data from LUSC tumors and came up with gene signatures for 34 genetic abnormalities whose expression changes throughout different precancerous stages. Several of these
Yupei Lin, Venugopalareddy Mekala, Jianrong Li, Xiang Wang, Muhammad Aminu, Jia Wu, Jianjun Zhang, Robert Taylor Ripley, Christopher I. Amos, Chao Cheng   +9 more
wiley   +1 more source

A high-coverage Neandertal genome from the Altai Mountains reveals population structure among Neandertals. [PDF]

Proc Natl Acad Sci U S A
Massilani D, Peyrégne S, Iasi LNM, de Filippo C, Mafessoni F, Bossoms Mesa A, Sümer AP, Swiel Y, Popli D, Silverman S, Boyle MJ, Kozlikin MB, Shunkov MV, Derevianko AP, Higham T, Douka K, Meyer M, Zeberg H, Kelso J, Pääbo S.   +19 more
europepmc   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

Karyological Diversification of <i>Trochoidea caroni</i> (Gastropoda, Pulmonata, Geomitridae) Between Sicilian and Non-Sicilian Populations. [PDF]

Animals (Basel)
Petraccioli A, Odierna G, Crovato P, Guarino FM, Carotenuto R, Sparacio I, Maio N.   +6 more
europepmc   +1 more source

Legume genome structures and histories inferred from Cercis canadensis and Chamaecrista fasciculata genomes. [PDF]

Plant J
Lee HO, Stai JS, Xu Q, Hewavithana T, Soman P, Batra R, Liu A, Jordan BD, Walstead R, Jenkins J, Williams M, Webber J, Grimwood J, Lovell JT, Brůna T, Shu S, Keymanesh K, Eichenberger J, Schmutz J, Goodstein DM, Barry K, Sankoff D, Jin L, Leebens-Mack JH, Cannon SB.   +24 more
europepmc   +1 more source

Multiplex gene editing suppresses random integration of hepatitis B virus DNA in chronically infected liver. [PDF]

Mol Ther Nucleic Acids
Slattery S, Huo W, Arif A, Gordon J, Takeuchi R.   +4 more
europepmc   +1 more source

NUP1/NUP136 is essential for obligatory crossover formation during meiosis in Arabidopsis. [PDF]

Genetics
Fernández-Jiménez N, Varas J, Martínez-García M, Santos JL, Pradillo M.   +4 more
europepmc   +1 more source