Results 101 to 110 of about 83,934 (227)

Eco‐Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron‐Rich Mobilomes and Cross‐Niche Connectivity

Advanced Science, EarlyView.
Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin, Biao Tang, Hao Xu, Jiajie Qian, Feifan Shi, Junhui Zhao, Xiaorui Mao, Xiaohe Hu, Ruishan Liu, Wenhong Liu, Xiawei Jiang, Beiwen Zheng, Guoping Zhao   +12 more
wiley   +1 more source

The role of Q-banding in the cytogenetic study of human spontaneous abortions

, 1973
The discovery of Q-banding made it possible to identify every member of the human chromosome complement. Spontaneous abortions known to have a better than average chance of presenting with a chromosome anomaly were selected for cytogenetic analysis.
McConnell, Dianne H.
core  

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Nuclear positioning and functional regulation of endogenous genes and transgenes in the fruit fly Drosophila melanogaster and in mammalian cells

, 2006
The goal of the work was to address the role of higher order nuclear architecture in the functional regulation of endogenous genes and transgenes in different species.
Rybakina, Elena
core  

PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes

Advanced Science, EarlyView.
A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li, Qizhe Zhang, Hanchen Chen, Kepeng Lin, Chengfang Luo, Mengying Yang, Wei Xu, Fan Yao, Jianbing Yan, Qing‐Yong Yang, Xuehai Hu   +10 more
wiley   +1 more source

Systematic analysis of genomic alterations in prostate cancer

, 2011
PhDProstate cancer is the most common male cancer in Western countries. The genetic mechanism underlying its initiation and progression is still unclear.
Mao, Xueying
core  

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Genomic-transcriptomic analysis identifies the Syrian hamster as a superior animal model for human diseases

Background The Syrian hamster (Mesocricetus auratus) has shown promise as a human diseases model, recapitulating features of different human diseases including COVID-19.
Xia Xue, Zhongxian Zhang, Cheng, Z, Shuangshuang Lu, Yunshu Dong, Wang, Zhizhong, Chuchu Wang, Xiaowei Li, Haoran Guo, Dong, Yunshu, Dong, Y, Chard Dunmall, Louisa S., Lu, Shuangshuang, Ding, Zhongren, Zhao, Xiaoyan, Fang, Guangming, Dong, Jianzeng, Ding, Z, Zhao, X, Tonge, D, Peng, Y, Cheng, Zhenguo, Zhongde Wang, Tan, W, Ling Li, Li, Ling, Guangming Fang, Jianzeng Dong, Zhao, L, Wang, Pengju, Zhizhong Wang, Zhang, Lirong, Zhimin Wang, Lirong Zhang, Jun Wang, Wang, Jianyao, Peng, Ying, Xue, X, Wang, Zhimin, Gao, Dongling, Nicholas R. Lemoine, Li, Xiaowei, Tan, Wenjie, Wang, Yaohe, Li, L, Zhenguo Cheng, Jinxin Miao, Louisa S Chard Dunmall, Fang, G, Gao, D, Wang, C, Wang, J, Tang, W, Pengju Wang, Miao, Jinxin, Zhang, Zhongxian, Lemoine, NR, Guo, H, Wang, P, Yaohe Wang, Ying Peng, Miao, J, Xiaoyan Zhao, Zhai, Y, Dongling Gao, Xue, Xia, Tonge, Daniel, Wang, Z, Wang, Y, Zhao, Li, Yafei Zhai, Wang, Chuchu, Jianyao Wang, Li Zhao, Wang, Jun, Zhongren Ding, Wang, Zhongde, Daniel Tonge, Zhang, Z, Wenjie Tan, Lu, S, Guo, Haoran, Dunmall, LSC, Li, X, Zhang, L, Wenxue Tang, Lemoine, Nicholas R., Dong, J, Zhai, Yafei, Tang, Wenxue   +89 more
core   +1 more source

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

An evolutionarily conserved early replicatig segment on the sex chromosomes of man and great apes [PDF]

, 1986
Weber, Bernhard, Wiesner, Henning, Schempp, Werner   +2 more
core