Results 21 to 30 of about 79,587 (203)

The effect of restriction enzyme digestion of human metaphase chromosomes on C-band variants of chromosomes 1 and 9

, 1988
Human metaphase chromosomes, fixed on slides, have been treated with 8 different restriction endonucleases and 29 combinations of 2 restriction enzymes prior to staining with Giemsa. The endonucleases AluI and DdeI and the combinations AluI + DdeI, AluI
M. Schürmann, Ute Hedemann, E. Schwinger   +2 more
core   +1 more source

Orphan CpG islands identify numerous conserved promoters in the mammalian genome [PDF]

, 2010
This work was funded by grants from the Wellcome Trust (077224; http://www.wellcome.ac.uk/) and the Medical Research Council (G0800026; http:// www.mrc.ac.uk/index.htm).CpG islands (CGIs) are vertebrate genomic landmarks that encompass the promoters of ...
Gruenewald-Schneider, Ulrike, Shaun Webb, Bird, A.P.; id_orcid, Webb, Shaun, Smith Colin, Kerr, A.R.W., Andrews, Robert, Keith D James, Daniel J. Turner, Turner, D.J., Webb, S., James, Keith D., James, K.D., Robert S Illingworth, Robert Andrews, Webb Shaun, Smith, Colin; id_orcid, Keith D. James, Harrison David J., David J. Harrison, Alastair R. W. Kerr, Bird, Adrian P., Gruenewald-Schneider, U., Gruenewald-Schneider Ulrike, Turner Daniel J., Andrews, R., Smith, Colin, Illingworth Robert S., Turner, Daniel J., Illingworth, Robert S., Ulrike Gruenewald-Schneider, David J Harrison, Bird Adrian P., Robert S. Illingworth, Alastair R W Kerr, Colin Smith, Andrews Robert, Kerr, Alastair R. W., Illingworth, R.S., Kerr Alastair R. W., Harrison, D.J., Daniel J Turner, James Keith D., Adrian P. Bird, Harrison, David J., Adrian P Bird   +45 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Diploid-specific genome stability genes of S. cerevisiae: genomic screen reveals haploidization as an escape from persisting DNA rearrangement stress. [PDF]

, 2011
Maintaining a stable genome is one of the most important tasks of every living cell and the mechanisms ensuring it are similar in all of them. The events leading to changes in DNA sequence (mutations) in diploid cells occur one to two orders of magnitude
Skoneczna, Adrianna, Malgorzata Alabrudzinska, Marek Skoneczny, Alabrudzinska Malgorzata, Skoneczna Adrianna, Skoneczny Marek, Alabrudzinska, Malgorzata, Skoneczny, Marek, Adrianna Skoneczna   +8 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Tomato protoplast DNA transformation: physical linkage and recombination of exogenous DNA sequences [PDF]

, 1987
Tomato protoplasts have been transformed with plasmid DNA's, containing a chimeric kanamycin resistance gene and putative tomato origins of replication.
Zabel, Pim, Jongsma, M., Koornneef, Maarten, Koornneef, M., Hille, Jacques,, Hille, J., Jongsma, Maarten, Zabel, P., Jongsma, Maarten,, Koornneef, Maarten,, Zabel, Pim,, Hille, Jacques   +11 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Identification of Type 1 Diabetes-Associated DNA Methylation Variable Positions That Precede Disease Diagnosis [PDF]

, 2011
Monozygotic (MZ) twin pair discordance for childhood-onset Type 1 Diabetes (T1D) is similar to 50%, implicating roles for genetic and non-genetic factors in the aetiology of this complex autoimmune disease.
Busato, F, Manfras, B, Kerith-rae M, Leslie, R. David, Jörg Tost, Manfras Burkhard, Mohammed I Hawa, Thomas A. Down, Maslau, S, Leslie, RD, Mohammed I. Hawa, Bernhard O Boehm, Beck Stephan, Rakyan, VK, Aden Deeqo, Daunay, A, Maslau Siarhei, Down Thomas A., Dias, Kerith-Rae M., Bell, Christopher G., Rakyan, Vardhman K., Boehm, Bernhard O., Beck, S, Bell Christopher G., Leslie R. David, Charles A. Mein, Charles A Mein, Boehm Bernhard O., Vardhman K Rakyan, Beyan, H, Burkhard Manfras, Christopher G. Bell, Hawa, MI, Kerith-Rae M. Dias, Vardhman K. Rakyan, R David Leslie, Kerith-Rae M Dias, Siarhei Maslau, Hawa Mohammed I., Busato Florence, Deeqo Aden, Bell, CG, Beck, Stephan, Stephan Beck, Bernhard O. Boehm, Busato, Florence, Dias Kerith-Rae M., Tost Jörg, Mein, Charles A., Christopher G Bell, Dias, KRM, Tost, J, Maslau, Siarhei, Hawa, Mohammed I., Daunay, Antoine, R. David Leslie, Florence Busato, Down, Thomas A., Rakyan Vardhman K., Tost, Jörg, Mein, CA, Daunay Antoine, Beyan, Huriya, Down, TA, Boehm, BO, Huriya Beyan, Antoine Daunay, Mein Charles A., Manfras, Burkhard, Thomas A Down, Beyan Huriya, Aden, D, Aden, Deeqo   +72 more
core   +1 more source