Results 71 to 80 of about 9,449,306 (346)

HumCFS: a database of fragile sites in human chromosomes

BMC Genomics, 2019
Background Fragile sites are the chromosomal regions that are susceptible to breakage, and their frequency varies among the human population. Based on the frequency of fragile site induction, they are categorized as common and rare fragile sites.
Rajesh Kumar, Gandharva Nagpal, Vinod Kumar, Salman Sadullah Usmani, Piyush Agrawal, Gajendra P. S. Raghava   +5 more
doaj   +1 more source

The 24 fluorescence patterns of the human metaphase chromosomes - distinguishing characters and variability.

Hereditas, 2009
Certain fluorescent DNA-binding compounds, among them quinacrine mustard and quinacrine, give characteristic banding patterns in human metaphase chromosomes; these patterns can be used to identify all the 24 chromosome types as well as chromosome ...
T. Caspersson, G. Lomakka, L. Zech
semanticscholar   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

IMACULAT - an open access package for the quantitative analysis of chromosome localization in the nucleus. [PDF]

PLoS ONE, 2013
The alteration in the location of the chromosomes within the nucleus upon action of internal or external stimuli has been implicated in altering genome function.
Ishita Mehta, Sandeep Chakraborty, Basuthkar J Rao   +2 more
doaj   +1 more source

Microdissection of human chromosomes by a laser microbeam [PDF]

, 1986
A laser microbeam apparatus, based on an excimer laser pumped dye laser is used to microdissect human chromosomes and to isolate a single chromosome ...
Berns, C. Cremer, Cremer, Cremer, De la Chapelle, Fisher, Gorodetsky, J. Wolfrum, K.O. Greulich, Kunkel, Lethokov, Röhme, S. Monajembashi, Scalenghe, T. Cremer, Walldorf   +15 more
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Human Ring Chromosomes – New Insights for their Clinical Significance

Balkan Journal of Medical Genetics, 2013
Twenty-nine as yet unreported ring chromosomes were characterized in detail by cytogenetic and molecular techniques. For FISH (fluorescence in situ hybridization) previously published high resolution approaches such as multicolor banding (MCB ...
Guilherme R.S., Klein E, Hamid A.B., Bhatt S, Volleth M, Polityko A, Kulpanovich A, Dufke A, Albrecht B, Morlot S, Brecevic L, Petersen M.B., Manolakos E, Kosyakova N, Liehr T   +14 more
doaj   +1 more source

DDX11L: a novel transcript family emerging from human subtelomeric regions

BMC Genomics, 2009
Background The subtelomeric regions of human chromosomes exhibit an extraordinary plasticity. To date, due to the high GC content and to the presence of telomeric repeats, the subtelomeric sequences are underrepresented in the genomic libraries and ...
D'Urso Michele, Matarazzo Maria R, Gianfrancesco Fernando, Roberto Roberta, Casamassimi Amelia, Costa Valerio, D'Esposito Maurizio, Rocchi Mariano, Ciccodicola Alfredo   +8 more
doaj   +1 more source

Detection of fluorescence in situ hybridization on human metaphase chromosomes by near-field scanning optical microscopy [PDF]

, 1995
Fluorescence in situ hybridization signals o­n human metaphase chromosomes are detected by a near-field scanning optical microscope. This makes it possible to localize and identify several fluorescently labeled genomic DNA fragments o­n a single ...
Jalocha, A., Jalocha, A., Moers, M.H.P., Moers, M.H.P., Ruiter, A.G.T., van Hulst, N.F.   +5 more
core   +3 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source