Results 71 to 80 of about 430,740 (285)

IMACULAT - an open access package for the quantitative analysis of chromosome localization in the nucleus. [PDF]

PLoS ONE, 2013
The alteration in the location of the chromosomes within the nucleus upon action of internal or external stimuli has been implicated in altering genome function.
Ishita Mehta, Sandeep Chakraborty, Basuthkar J Rao   +2 more
doaj   +1 more source

RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells. [PDF]

, 2015
The RAD54 family DNA translocases have several biochemical activities. One activity, demonstrated previously for the budding yeast translocases, is ATPase-dependent disruption of RAD51-dsDNA binding.
Bishop, Douglas K, Budke, Brian, Connell, Philip P, Dusad, Kritika, Grubb, Jennifer, Heyer, Wolf-Dietrich, Mason, Jennifer M, Weichselbaum, Ralph R, Wright, William Douglass   +8 more
core   +2 more sources

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Human Ring Chromosomes – New Insights for their Clinical Significance

Balkan Journal of Medical Genetics, 2013
Twenty-nine as yet unreported ring chromosomes were characterized in detail by cytogenetic and molecular techniques. For FISH (fluorescence in situ hybridization) previously published high resolution approaches such as multicolor banding (MCB ...
Guilherme R.S., Klein E, Hamid A.B., Bhatt S, Volleth M, Polityko A, Kulpanovich A, Dufke A, Albrecht B, Morlot S, Brecevic L, Petersen M.B., Manolakos E, Kosyakova N, Liehr T   +14 more
doaj   +1 more source

Impaired CENP-E Function Renders Large Chromosomes More Vulnerable to Congression Failure

Biomolecules, 2019
It has recently emerged that human chromosomes vary between one another in terms of features that impact their behaviour during impaired chromosome segregation, leading to non-random aneuploidy in the daughter cell population.
Laura Tovini, Sarah E. McClelland
doaj   +1 more source

Structural fingerprints of transcription factor binding site regions [PDF]

, 2009
Fourier transforms are a powerful tool in the prediction of DNA sequence properties, such as the presence/absence of codons. We have previously compiled a database of the structural properties of all 32,896 unique DNA octamers.
Christopher Hunter, Collins, Eleanor J. Gardiner, Fickett, Kampa, Packer, Peter Willett, Tiwari, Waterston   +8 more
core   +2 more sources

Human chromosome 8. [PDF]

Journal of Medical Genetics, 1988
The role of human chromosome 8 in genetic disease together with the current status of the genetic linkage map for this chromosome is reviewed. Both hereditary genetic disease attributed to mutant alleles at gene loci on chromosome 8 and neoplastic disease owing to somatic mutation, particularly chromosomal translocations, are discussed.
openaire   +3 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Pericentromeric organization at the fusion point of mouse Robertsonian translocation chromosomes [PDF]

, 2001
In mammals, Robertsonian (Rb) translocation (the joining of two telo/acrocentric chromosomes at their centromere to form a metacentric) is the most effective process in chromosomal evolution leading to speciation; its occurrence also affects human health
Capanna, E., Garagna, S., Marziliano, N., Redi, C.A., Searle, J.B., Zuccotti, M.   +5 more
core   +3 more sources