Results 261 to 270 of about 1,562,582 (397)

Adenylosuccinate Synthase 1 Deficiency Improves Energy Metabolism by Promoting Adipose Tissue Re‐esterification via Glycerol Kinase Upregulation

Advanced Science, EarlyView.
Working model of Adss1‐mediated regulation of energy metabolism in adipose tissue. In beige adipocytes, Adss1 interacts with HDAC3 in the cytoplasm, and its loss reduces nuclear HDAC3 while increasing cytosolic fractions. This redistribution suppresses HDAC activity and enhances H3K27 acetylation at the Gk promoter, leading to transcriptional ...
Jingjing Sun, Miriayi Alimujiang, Wenfei Li, Shuqin Chen, Yingying Su, Tingting Hu, Xuhong Lu, Yafen Ye, Ningning Bai, Fan Hu, Xiaoya Li, Rongrong Xu, Jun Xu, Jiarui Zhao, Yan Lu, Xiaojing Ma, Ying Yang   +16 more
wiley   +1 more source

Motorized chromosome models of mitotic chromosome folding. [PDF]

Nat Commun
Cao Z, Du C, Hou Z, Wolynes PG.
europepmc   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Human selection maintains karyotype integrity of highly unstable genomic cultivated autotetraploid potato (<i>Solanum tuberosum</i>). [PDF]

Sci Adv
Yang L, Bai Y, Chao G, Zhao K, Xu J, Sun M, Zhang H, Niu Y, Li K, Xiong Z, Cao Y, Wang F, Hai B, Cao C, Yin Y, Lin T, Wang Y, Gong X, Wu L, Jiang J, Xiong Z.   +20 more
europepmc   +1 more source

Tumor‐Informed ctDNA in Guiding First‐Line Immunochemotherapy in Advanced Non‐Small Cell Lung Cancers

Advanced Science, EarlyView.
Tumor‐informed circulating tumor DNA (ctDNA) analysis identifies patients with advanced non‐small cell lung cancer (NSCLC) who benefit from first‐line immunotherapy plus chemotherapy. Longitudinal ctDNA monitoring further reflects therapeutic response and predicts prognosis beyond imaging.
Kailun Fei, Jie Zhao, Jiachen Xu, Jianchun Duan, Chengcheng Li, Wenchuan Xie, Jia Zhong, Guoqiang Wang, Yu Xu, Boyang Sun, Rui Wan, Hua Bai, Qinxiang Guo, Wei Guo, Shangli Cai, Zhijie Wang, Jie Wang   +16 more
wiley   +1 more source

SEX CHROMOSOMES AND THE EVOLUTION OF SEXUAL DIMORPHISM

Evolution; international journal of organic evolution, 1984
W. Rice
semanticscholar   +1 more source

Creating New Forms of Hexaploid Triticale Associating Complete R and D Genomes. [PDF]

Biology (Basel)
Bernard M, Bernard S, Badaeva E, Schlegel R.   +3 more
europepmc   +1 more source

Estrogen influences class-switched memory B cell frequency only in humans with two X chromosomes [PDF]

Hannah Peckham, Anna Radziszewska, Justyna Sikora, Nina M. de Gruijter, Restuadi Restuadi, Melissa Kartawinata, Lucia Martin‐Gutierrez, George Robinson, Claire T. Deakin, Lucy R. Wedderburn, Elizabeth C. Jury, Gary Butler, Emma S. Chambers, Elizabeth C. Rosser, Coziana Ciurtin   +14 more
openalex   +1 more source

High‐Resolution Genomic Resources for Trait Mapping and Precision Breeding for Adzuki Bean (Vigna angularis)

Advanced Science, EarlyView.
This study establishes crucial genomic resources for adzuki bean, including a reference genome, variation map, and the AdzukiBeanAtlas toolkit. We identify key candidate genes (ANKRD50, NAC73, ANR1, NPF5.4) for important agronomic traits through Genome‐Wide Association Studies (GWAS).
Liangliang Hu, Xiaolei Wang, Yazhou Zhang, Vanika Garg, Xingxing Yuan, Renfeng Xue, Hongmei Zhou, Yanhua Chen, Weili Hu, Rutwik Barmukh, Rong Cao, Tianxiao Chen, Qiannan Song, Dan Gao, Gaoling Luo, Xu Zhu, Xin Jing, Suhua Wang, Caiju Li, Yunshan Wei, Weide Ge, Xin Chen, Lixia Wang, Rajeev K Varshney, Chengzhi Jiao, Xuzhen Cheng, Honglin Chen   +26 more
wiley   +1 more source

The role of toxin/antidote genes in the maintenance and evolution of accessory chromosomes in Fusarium. [PDF]

Genetics
Sandell L, Forsythe A, Mirandola A, Jorayev S, Urquhart AS, Granger Farbos A, Saupe SJ, Vogan AA.   +7 more
europepmc   +1 more source