Results 121 to 130 of about 10,167,326 (383)

Leprosy-associated chronic wound management using biomaterials

Journal of Global Infectious Diseases, 2018
Background: Deformities and neuropathic chronic ulcers are the common features associated with leprosy-cured individuals that impact their quality of life and impair rehabilitation efforts.
Srinivasan Sivasubramanian, Sambasivam Mohana, Paulraj Maheswari, Victor Victoria, Ramar Thangam, Jayashri Mahalingam, Gayathri Chandrasekar-Janebjer, Vincent Savariar, Balaraman Madhan, Palani Gunasekaran, Satish S Kitambi   +10 more
doaj   +1 more source

Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease.

New England Journal of Medicine, 2007
BACKGROUND Long-acting beta-agonists and inhaled corticosteroids are used to treat chronic obstructive pulmonary disease (COPD), but their effect on survival is unknown.
P. Calverley, Julie A. Anderson, B. Celli, G. Ferguson, C. Jenkins, P. Jones, J. Yates, J. Vestbo   +7 more
semanticscholar   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Adolescent Alcohol Drinking Renders Adult Drinking BLA-Dependent: BLA Hyper-Activity as Contributor to Comorbid Alcohol Use Disorder and Anxiety Disorders

Brain Sciences, 2017
Adolescent alcohol drinking increases the risk for alcohol-use disorder in adulthood. Yet, the changes in adult neural function resulting from adolescent alcohol drinking remain poorly understood.
Mahsa Moaddab, Elizabeth Mangone, Madelyn H. Ray, Michael A. McDannald   +3 more
doaj   +1 more source

Epidemiology of chronic kidney disease: an update 2022.

Kidney international. Supplement, 2022
C. Kovesdy
semanticscholar   +1 more source

Global Initiative for Chronic Obstructive Lung Disease (GOLD)

, 2017
not available Anwer Khan Modern Medical College Journal Vol. 7, No.
Mahmudur Rahman, M. R. Siddiqui
semanticscholar   +1 more source

Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia.

New England Journal of Medicine, 2011
We designed a lentiviral vector expressing a chimeric antigen receptor with specificity for the B-cell antigen CD19, coupled with CD137 (a costimulatory receptor in T cells [4-1BB]) and CD3-zeta (a signal-transduction component of the T-cell antigen ...
D. Porter, B. Levine, M. Kalos, A. Bagg, C. June   +4 more
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Life events, difficulties and dilemmas in the onset of chronic fatigue syndrome: a case-control study [PDF]

, 2003
Background. The role of stress in the onset of chronic fatigue syndrome is unclear. Our objectives in this study were first, to determine the relation between the onset of chronic fatigue syndrome and stressful life events and difficulties.
Hatcher, S., House, A.
core   +1 more source

How I Manage Patients with Chronic Myeloid Leukemia (CML): Perspectives from Clinical Practice

Blood and Lymphatic Cancer: Targets and Therapy, 2022
Guru Subramanian Guru Murthy Division of Hematology & Oncology, Medical College of Wisconsin, Milwaukee, WI, USACorrespondence: Guru Subramanian Guru Murthy, Division of Hematology & Oncology, Medical College of Wisconsin, Milwaukee, WI, USA, Tel +1 414 ...
Guru Murthy GS
doaj