Results 1 to 10 of about 5,063,263 (354)

Inhibiting ERK Activation with CI-1040 Leads to Compensatory Upregulation of Alternate MAPKs and Plasminogen Activator Inhibitor-1 following Subtotal Nephrectomy with No Impact on Kidney Fibrosis [PDF]

, 2015
Extracellular-signal regulated kinase (ERK) activation by MEK plays a key role in many of the cellular processes that underlie progressive kidney fibrosis including cell proliferation, apoptosis and transforming growth factor β1-mediated epithelial to ...
AA Eddy, Arif Khwaja, B Conway, B Hinz, C Stambe, D Bokemeyer, D Bokemeyer, D Feliers, David Long, DY Rhyu, E Diaz-Flores, Faith Hannah Nutter, FY Ma, FY Ma, FY Ma, G Wolf, GA Reif, GM D'Abaco, H Fujita, H Ha, H Tamouza, HJ Anders, J Chen, John L. Haylor, JW Pippin, JY Seo, L Aoudjit, LF Allen, LL Huang, M Peake, M Sabbatini, M Zeisberg, MA Chetram, MH De Borst, N Sakai, P Moreno-Layseca, PM Lorusso, R Ohashi, R Roskoski Jr, S Omori, S Wang, S Wang, SD Oldroyd, SK Jo, SP Davies, T Ishida, T Masaki, T Wada, T Xu, W Bechtel, Y Han   +50 more
core   +10 more sources

Inhibition of calpain9 attenuates peritoneal dialysis-related peritoneal fibrosis

Frontiers in Pharmacology, 2022
Aim: Peritoneal dialysis is a common renal replacement method for end-stage renal disease. Long-term peritoneal dialysis leads to peritoneal dialysis-related peritoneal fibrosis, which leads to a cessation of treatment.
Fang Li, Yu Wang, Jianwei Tian, Zhanmei Zhou, Wei Yin, Xianhui Qin, Huizhen Wang, Tao Zeng, Aiqing Li, Jianping Jiang   +9 more
doaj   +1 more source

Circular RNA circBNC2 inhibits epithelial cell G2-M arrest to prevent fibrotic maladaptive repair

Nature Communications, 2022
G2/M arrest of epithelial cells leads to fibrosis with unclear mechanisms. This study identifies a protein-encoding circRNA, circBNC2, which inhibits epithelial cells G2/M arrest to prevent fibrotic maladaptive repair in damaged kidney and liver ...
Peng Wang, Zhitao Huang, Yili Peng, Hongwei Li, Tong Lin, Yingyu Zhao, Zheng Hu, Zhanmei Zhou, Weijie Zhou, Youhua Liu, Fan Fan Hou   +10 more
doaj   +1 more source

Association of a Healthy Lifestyle, Life's Essential 8 Scores With Incident Macrovascular and Microvascular Disease Among Individuals With Type 2 Diabetes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background The association of a healthy lifestyle with the prognosis of type 2 diabetes remains uncertain. We aimed to evaluate the associations of a healthy lifestyle and a higher American Heart Association's Life's Essential 8 score with incident ...
Panpan He, Huan Li, Ziliang Ye, Mengyi Liu, Chun Zhou, Qimeng Wu, Yanjun Zhang, Sisi Yang, Yuanyuan Zhang, Xianhui Qin   +9 more
doaj   +1 more source

Peer support interventions in patients with kidney failure: A systematic review.

Journal of Psychosomatic Research, 2023
BACKGROUND Peer support has been associated with improved health-related outcomes (e.g., psychological well-being and treatment adherence) among patients with serious, chronic conditions, including kidney disease.
Regina M. Longley, Lauren E. Harnedy, Pia Maria Ghanimé, Daniel Arroyo-Ariza, Emma C. Deary, Elizabeth Daskalakis, K. G. Sadang, J. West, Jeff C. Huffman, C. Celano, H. Amonoo   +10 more
semanticscholar   +1 more source

Survival for waitlisted kidney failure patients receiving transplantation versus remaining on waiting list: systematic review and meta-analysis

British medical journal, 2022
Objectives To investigate the survival benefit of transplantation versus dialysis for waitlisted kidney failure patients with a priori stratification. Design Systematic review and meta-analysis.
Daoud Chaudhry, A. Chaudhry, Javeria Peracha, A. Sharif   +3 more
semanticscholar   +1 more source

Kidney tubular epithelial cells control interstitial fibroblast fate by releasing TNFAIP8-encapsulated exosomes

Cell Death and Disease, 2023
Kidney fibrosis, characterized by the activation and expansion of the matrix-producing fibroblasts, is the common outcome of chronic kidney disease (CKD).
Xi Liu, Zhao Liu, Cong Wang, Jinhua Miao, Shan Zhou, Qian Ren, Nan Jia, Lili Zhou, Youhua Liu   +8 more
doaj   +1 more source

Determinants of Kidney Failure in Primary Hyperoxaluria Type 1: Findings of the European Hyperoxaluria Consortium

Kidney International Reports, 2023
Introduction Primary hyperoxaluria type 1 (PH1) has a highly heterogeneous disease course. Apart from the c.508G>A (p.Gly170Arg) AGXT variant, which imparts a relatively favorable outcome, little is known about determinants of kidney failure. Identifying
Elisabeth L. Metry, Sander F. Garrelfs, Lisa J. Deesker, C. Acquaviva, V. D'Ambrosio, J. Bacchetta, Bodo B. Beck, P. Cochat, L. Collard, J. Hogan, P. M. Ferraro, C. Franssen, J. Harambat, S. Hulton, G. Lipkin, G. Mandrile, Cristina Martín-Higueras, N. Mohebbi, S. Moochhala, T. Neuhaus, L. Prikhodina, E. Salido, R. Topaloğlu, M. Oosterveld, J. Groothoff, H. Peters-Sengers   +25 more
semanticscholar   +1 more source

Utility of the Kidney Failure Risk Equation and Estimated GFR for Estimating Time to Kidney Failure in Advanced CKD.

American Journal of Kidney Diseases, 2023
RATIONALE & OBJECTIVE The Kidney Failure Risk Equation (KFRE) predicts the 2-year risk of kidney failure for patients with chronic kidney disease (CKD). Translating KFRE-predicted risk or eGFR into time to kidney failure could inform decision-making for ...
Chi D. Chu, C. McCulloch, Raymond K. Hsu, N. Powe, B. Bieber, B. Robinson, R. Raina, R. Pecoits-Filho, D. Tuot   +8 more
semanticscholar   +1 more source

Matrix metalloproteinase-10 protects against acute kidney injury by augmenting epidermal growth factor receptor signaling

Cell Death and Disease, 2021
Matrix metalloproteinase-10 (MMP-10) is a zinc-dependent endopeptidase involved in regulating a wide range of biologic processes, such as apoptosis, cell proliferation, and tissue remodeling.
Chengxiao Hu, Yangyang Zuo, Qian Ren, Xiaoli Sun, Shan Zhou, Jinlin Liao, Xue Hong, Jinhua Miao, Lili Zhou, Youhua Liu   +9 more
doaj   +1 more source